GRIA2 and DRD2

Number of citations of the paper that reports this interaction (PubMedID 15858065)
86

Data Source:
HPRD (in vitro, in vivo)

		GRIA2	DRD2
Description		glutamate ionotropic receptor AMPA type subunit 2	dopamine receptor D2
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Postsynaptic Density Membrane Dendrite Endocytic Vesicle Membrane Asymmetric Synapse AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Postsynapse Postsynaptic Density Membrane Postsynaptic Endocytic Zone	Golgi Membrane Acrosomal Vesicle Golgi Apparatus Plasma Membrane Cilium Membrane Lateral Plasma Membrane Endocytic Vesicle Axon Dendrite Synaptic Vesicle Membrane Sperm Flagellum Presynaptic Membrane Dendritic Spine Perikaryon Axon Terminus Synapse Postsynaptic Membrane Ciliary Membrane G Protein-coupled Receptor Complex Non-motile Cilium Dopaminergic Synapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Amyloid-beta Binding Glutamate-gated Receptor Activity AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Cation Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Heterotrimeric G-protein Binding Dopamine Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Monoatomic Ion Transport Signal Transduction Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Monoatomic Cation Transmembrane Transport	Temperature Homeostasis Response To Hypoxia Neuron Migration Synaptic Transmission, Dopaminergic Startle Response Response To Amphetamine Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Heart Rate Regulation Of Sodium Ion Transport G Protein-coupled Receptor Internalization Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Receptor Internalization Intracellular Calcium Ion Homeostasis Autophagy Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Neuroblast Proliferation Axonogenesis Synapse Assembly Sensory Perception Of Smell Long-term Memory Grooming Behavior Locomotory Behavior Adult Walking Behavior Feeding Behavior Intracellular Protein Localization Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Associative Learning Visual Learning Response To Xenobiotic Stimulus Response To Light Stimulus Response To Toxic Substance Response To Iron Ion Regulation Of Dopamine Secretion Response To Inactivity Wnt Signaling Pathway Cell Migration Striatum Development Orbitofrontal Cortex Development Cerebral Cortex GABAergic Interneuron Migration Adenohypophysis Development Negative Regulation Of Cell Migration Peristalsis Adult Behavior Forebrain Development Auditory Behavior Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Negative Regulation Of Dopamine Secretion Response To Histamine Response To Nicotine Negative Regulation Of Dephosphorylation Intracellular Signal Transduction Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Multicellular Organism Growth Response To Cocaine Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Dopamine Metabolic Process Drinking Behavior Regulation Of Potassium Ion Transport Response To Morphine Regulation Of MAPK Cascade Pigmentation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Ethanol Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Blood Pressure Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Acid Secretion Behavioral Response To Cocaine Behavioral Response To Ethanol Regulation Of Long-term Neuronal Synaptic Plasticity Response To Axon Injury Branching Morphogenesis Of A Nerve Arachidonate Secretion Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Secretion Positive Regulation Of Neurogenesis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Synaptic Transmission Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Neurotransmitter Uptake Dopamine Uptake Involved In Synaptic Transmission Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Synapse Structural Plasticity Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Amine Transport Negative Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Positive Regulation Of Growth Hormone Secretion Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Ethanol Regulation Of Locomotion Involved In Locomotory Behavior Postsynaptic Modulation Of Chemical Synaptic Transmission Presynaptic Modulation Of Chemical Synaptic Transmission Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Negative Regulation Of Cellular Response To Hypoxia Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Secretion By Cell Hyaloid Vascular Plexus Regression Negative Regulation Of Neuron Migration
Pathways		Activation of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation MECP2 regulates neuronal receptors and channels Long-term potentiation	Dopamine receptors
Drugs		Glutamic acid Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Ethanol Phenobarbital Quinidine barbiturate Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione (S)-DES-ME-AMPA (S)-AMPA 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid Iodo-Willardiine Fluoro-Willardiine Quisqualic acid (S)-2-Amino-3-(1,3,5,7-Pentahydro-2,4-Dioxo-Cyclopenta[E]Pyrimidin-1-Yl) Proionic Acid (2S)-2-Ammonio-3-[5-(2-methyl-2-propanyl)-3-oxido-1,2-oxazol-4-yl]propanoate FG-9041 Bromo-Willardiine Willardiine 2-Amino-3-(3-Hydroxy-7,8-Dihydro-6h-Cyclohepta[D]-4-Isoxazolyl)Propionic Acid Aniracetam THIO-ATPA Talampanel CX-717 N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dimethanesulfonamide 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide Fluciclovine (18F)	Amphetamine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Olanzapine Clozapine Thiethylperazine Sulpiride Loxapine Remoxipride Pramipexole Promazine Prochlorperazine Droperidol Imipramine Chlorpromazine Buspirone Haloperidol Triflupromazine Nortriptyline Amoxapine Lamotrigine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Trifluoperazine Perphenazine Flupentixol Amantadine Mesoridazine Maprotiline Dopamine Carphenazine Memantine Ergoloid mesylate Acetophenazine Promethazine Pimozide Desipramine Escitalopram Domperidone Pergolide Bromocriptine Ketamine Quetiapine Metoclopramide Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Alizapride Rolicyclidine Acepromazine Molindone Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Aniracetam Fluspirilene Tetrabenazine Brasofensine Bifeprunox Bicifadine Itopride Iloperidone Rotigotine BL-1020 Norclozapine Amitifadine Cariprazine Lumateperone YKP-1358 Sertindole Mianserin Asenapine Ocaperidone Amisulpride Sarizotan Sumanirole Nandrolone decanoate Lurasidone Perospirone Bromopride Quinagolide Brexpiprazole Etoperidone AS-8112 Blonanserin Melperone Zotepine Pipamperone Dihydro-alpha-ergocryptine Epicriptine Pardoprunox Tetrahydropalmatine Piribedil Raclopride JNJ-37822681 Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Triglyceride levels x loop diuretics use interaction ( 31806883)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30679032 30643258) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 33861876) Alcoholic chronic pancreatitis ( 28754779) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety ( 33859377) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33263727) Body mass index ( 26426971) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 33859377) General factor of neuroticism ( 30867560) Inferior temporal gyrus volume ( 31530798) Information processing speed ( 25869804) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Mood instability ( 31168069) Neuroticism ( 29255261 27089181) Problematic alcohol use ( 32451486) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309) Schizophrenia ( 30285260 29483656 28991256 25056061) Select biomarker traits ( 17903293) Sleep duration ( 27992416) Smoking cessation ( 33082346) Smoking status (current vs mixed) ( 33082346) Smoking status (current vs never) ( 33082346) Sociability score ( 34054130) Systolic blood pressure in sickle cell anemia ( 24058526) Triglycerides ( 30275531) Walking pace ( 33128006) Worry too long after an embarrassing experience ( 34054130)
Interacting Genes		21 interacting genes: CTTN CYLD DRD2 FXR1 GAPDH GRIA3 GRIP2 GSK3B GTF3C2 ITGB3 NSF PICK1 PRKCA RAC1 RNF167 SDCBP SPTAN1 SPTBN1 SQSTM1 SYT3 TSPAN7	86 interacting genes: ABCA2 ADGRB1 ADGRG1 ADORA2A APH1A ARL1 ARL6IP6 ATP6V0A2 ATP6V0C BCAP29 BCAP31 CADPS CADPS2 CALM1 CALM3 CCKBR CERS1 CERS2 CHPT1 CLDND1 CLIC6 CRELD1 EPB41 EPB41L1 FLNA GABBR1 GABBR2 GDPD2 GHITM GIPC1 GNAI2 GNAI3 GNAZ GNB5 GPR137 GPR37 GRIA2 GRINA HRH3 KBTBD6 KBTBD7 KCNJ6 KCNJ9 LPAR1 NCS1 NDUFV1 NEFM NSF OPRM1 PAQR6 PAWR PIGG PLLP PLPPR3 PPP1R9B RHBDD2 RTN1 RTN3 RTN4 SERINC3 SLC15A4 SLC22A17 SLC35B1 SLC4A3 SLC6A1 SLC6A3 SMIM7 SPP1 SSTR2 SSTR5 SYNGR2 TF TMEFF2 TMEM101 TMEM11 TMEM63A TRAM1 TRPC4 TRPC5 TSPAN3 TSPAN7 TTYH1 WFS1 WLS YIPF3 ZDHHC4
Entrez ID		2891	1813
HPRD ID		04726	00539
Ensembl ID		ENSG00000120251	ENSG00000149295
Uniprot IDs		A0A994J4F1 P42262	P14416
PDB IDs		2WJW 2WJX 2XHD 3R7X 3RN8 3RNN 3UA8 5H8S 5YBF 5YBG 5ZG0 5ZG1 5ZG2 5ZG3 7F3O 8I0B	5AER 6CM4 6LUQ 6VMS 7DFP 7JVR 8IRS 8TZQ 8U02
Enriched GO Terms of Interacting Partners?		Glutamatergic Synapse Plasma Membrane Regulation Of Synaptic Plasticity Regulation Of Biological Quality Positive Regulation Of Signaling Regulation Of Organelle Organization Synapse Modulation Of Chemical Synaptic Transmission Regulation Of Signaling Regulation Of Cytoskeleton Organization Regulation Of Vesicle-mediated Transport Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Cell Communication Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Cellular Component Organization Chemical Synaptic Transmission Regulation Of Receptor Internalization Localization Within Membrane Trans-synaptic Signaling Regulation Of Actin Cytoskeleton Organization Synaptic Signaling Regulation Of Secretion By Cell Alphav-beta3 Integrin-PKCalpha Complex Vesicle-mediated Transport Regulation Of Actin Filament-based Process Ionotropic Glutamate Receptor Binding Regulation Of Secretion Cellular Component Assembly Postsynapse Membrane Membrane Organization Positive Regulation Of Signal Transduction Regulation Of Cellular Component Size Positive Regulation Of Protein Localization Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Actin Filament Polymerization Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Actin Filament Organization Positive Regulation Of Developmental Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Neuron Projection Organization Regulation Of Actin Polymerization Or Depolymerization Protein Kinase C Binding Regulation Of Actin Filament Length Intracellular Membraneless Organelle	Membrane Plasma Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Monoatomic Ion Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Inorganic Ion Transmembrane Transport Synapse Dendrite Inorganic Cation Transmembrane Transport Regulation Of Transport Presynaptic Membrane Metal Ion Transport G Protein-coupled Receptor Activity Endoplasmic Reticulum Membrane Golgi Membrane Dendritic Shaft Endoplasmic Reticulum Tubular Network Formation Amino Acid Transport Neuronal Cell Body Negative Regulation Of Voltage-gated Calcium Channel Activity Endoplasmic Reticulum Tubular Network Membrane Organization Calcium Channel Complex Neuropeptide Binding Regulation Of Signaling Negative Regulation Of Adenylate Cyclase Activity Dendritic Spine Negative Regulation Of High Voltage-gated Calcium Channel Activity G Protein-coupled GABA Receptor Activity G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex Heterotrimeric G-protein Complex Secretion Regulation Of Cell Communication Golgi Apparatus Postsynaptic Membrane Positive Regulation Of Signaling Regulation Of Voltage-gated Calcium Channel Activity Membrane Organization Gamma-delta T Cell Receptor Complex GABA Receptor Complex Ligand-gated Monoatomic Cation Channel Activity Cellular Response To Morphine D2 Dopamine Receptor Binding Endoplasmic Reticulum Membrane Organization Regulation Of Secretion By Cell
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