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NPAS2 and ARNT
Number of citations of the paper that reports this interaction (PubMedID
9576906
)
35
Data Source:
BioGRID
(two hybrid, two hybrid, pull down)
NPAS2
ARNT
Description
neuronal PAS domain protein 2
aryl hydrocarbon receptor nuclear translocator
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
CLOCK-BMAL Transcription Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Nuclear Body
Aryl Hydrocarbon Receptor Complex
Nuclear Aryl Hydrocarbon Receptor Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Metal Ion Binding
Protein Dimerization Activity
Hsp90 Protein Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Aryl Hydrocarbon Receptor Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Protein Dimerization Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response
Central Nervous System Development
Response To Xenobiotic Stimulus
Regulation Of Gene Expression
Circadian Regulation Of Gene Expression
Positive Regulation Of DNA Repair
Positive Regulation Of DNA-templated Transcription
Rhythmic Process
Response To Redox State
Positive Regulation Of Behavioral Fear Response
Response To Hypoxia
Embryonic Placenta Development
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Vascular Endothelial Growth Factor Production
Cell Differentiation
Intracellular Receptor Signaling Pathway
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Protein Sumoylation
Cellular Response To Oxidative Stress
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hormone Biosynthetic Process
Negative Regulation Of Inflammatory Response
Intestinal Epithelial Structure Maintenance
Pathways
BMAL1:CLOCK,NPAS2 activates circadian expression
PPARA activates gene expression
Heme signaling
Expression of BMAL (ARNTL), CLOCK, and NPAS2
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Regulation of gene expression by Hypoxia-inducible Factor
PPARA activates gene expression
Phase I - Functionalization of compounds
Endogenous sterols
Xenobiotics
Aryl hydrocarbon receptor signalling
NPAS4 regulates expression of target genes
NPAS4 regulates expression of target genes
Drugs
Diseases
GWAS
Aspartate aminotransferase levels (
33547301
)
Chronotype (
30696823
)
Creutzfeldt-Jakob disease (variant) (
22137330
)
Educational attainment (
25201988
)
Hip circumference adjusted for BMI (
34021172
)
Intraocular pressure (
30054594
31798171
31959993
)
Intraocular pressure and central corneal thickness (multi-trait analysis) (
31798171
)
Metabolite levels (
23823483
)
Obsessive-compulsive traits (
33531474
)
Platelet distribution width (
32888494
)
Pulse pressure (
27841878
)
White blood cell count (
32888494
)
Body mass index (
26426971
)
Congenital left-sided heart lesions (
26965164
)
Cutaneous squamous cell carcinoma (
32041948
)
Estimated glomerular filtration rate (
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Fasting glucose (
34059833
)
Hip circumference adjusted for BMI (
34021172
)
Melanoma (
21983785
28212542
)
Metabolic syndrome (
31589552
)
Platelet count (
32888494
)
Rhegmatogenous retinal detachment (
23585552
)
Tea consumption (
31046077
)
Urate levels (
23263486
)
Interacting Genes
29 interacting genes:
ARNT
ARNT2
BMAL1
BPIFA1
CREBBP
CRX
CRY1
CRY2
CSNK2B
DELEC1
EFS
EP300
HESX1
HGS
HSP90AA1
INCA1
KAT2B
NCK2
NCOA3
NGLY1
RARA
RASSF7
RHOXF1
RORC
RPL6
RXRA
TRAF4
UBAP2
ZSCAN1
78 interacting genes:
ADH5
AHR
AHRR
AIP
AKT1
ARL14
ARNT2
BECN1
BRCA1
CALCOCO1
CASP3
CASP9
CCND2
CCNE1
CD44
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CLOCK
CSNK2A1
DIABLO
EP300
EPAS1
EPHA2
ERBB2
ESR1
FGFR4
FZR1
GLIS1
GLIS2
GMNN
GTF2F1
GTF2F2
HEY1
HEY2
HGF
HIF1A
HIF3A
HNF4A
IRAK4
KPNA1
KPNA3
KPNA5
KPNA6
LATS2
LSM8
MAP2K5
MAPK14
MTA3
MYC
NCOA1
NCOA2
NCOA7
NCOR2
NF2
NPAS2
NPAS4
PDGFRA
PML
PTGES3
RAF1
RELA
SENP6
SIM1
SIM2
SMAD9
SP1
STK11
STRBP
TACC3
TEAD2
TGM2
TNFAIP1
TRIP11
TUBB2A
UBE2I
Entrez ID
4862
405
HPRD ID
09137
00524
Ensembl ID
ENSG00000170485
ENSG00000143437
Uniprot IDs
A2I2P5
Q99743
A8K6P0
B0AZM1
P27540
Q53F30
PDB IDs
1X0O
2A24
2B02
2HV1
2K7S
3F1N
3F1O
3F1P
3H7W
3H82
4EQ1
4GHI
4GS9
4H6J
4LPZ
4PKY
4XT2
5TBM
5UFP
5V0L
6CZW
6D09
6D0B
6D0C
6X21
6X28
6X2H
6X37
6X3D
8CK3
8CK4
8CK8
8G4A
8XS6
8XS7
8XS8
8XS9
8XSA
8XSB
Enriched GO Terms of Interacting Partners
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Chromatin
Transcription Regulator Complex
Intracellular Receptor Signaling Pathway
N-terminal Peptidyl-lysine Acetylation
Nuclear Receptor Binding
Regulation Of Primary Metabolic Process
Sequence-specific Double-stranded DNA Binding
Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Protein-lysine-acetyltransferase Activity
Regulation Of Metabolic Process
Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Nuclear Protein Quality Control By The Ubiquitin-proteasome System
Regulation Of DNA-templated Transcription
Aryl Hydrocarbon Receptor Binding
Regulation Of RNA Biosynthetic Process
Aryl Hydrocarbon Receptor Complex
Rhythmic Process
Histone Acetyltransferase Activity
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
N-terminal Protein Amino Acid Acetylation
Positive Regulation Of Biosynthetic Process
Peptidyl-lysine Acetylation
Positive Regulation Of Macromolecule Metabolic Process
Nuclear Receptor Activity
DNA Binding
Transcription Coregulator Activity
Negative Regulation Of Transcription By RNA Polymerase II
Histone H3K27 Acetyltransferase Activity
Blue Light Signaling Pathway
DNA (6-4) Photolyase Activity
Deoxyribodipyrimidine Photo-lyase Activity
Blue Light Photoreceptor Activity
Circadian Rhythm
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Nucleus
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Acetyltransferase Activity
Hormone-mediated Signaling Pathway
Circadian Regulation Of Gene Expression
Positive Regulation Of Metabolic Process
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Protein Modification Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Positive Regulation Of DNA-templated Transcription
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Protein Dimerization Activity
Regulation Of RNA Metabolic Process
Nucleoplasm
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Chromatin
Positive Regulation Of Metabolic Process
Transcription Regulator Complex
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of Cell Population Proliferation
Regulation Of Macromolecule Biosynthetic Process
Intracellular Signal Transduction
Regulation Of Gene Expression
Rhythmic Process
Developmental Process
Cytoplasm
Cell Differentiation
Regulation Of Cell Cycle
Signal Transduction
Animal Organ Development
Transcription By RNA Polymerase II
Regulation Of Apoptotic Process
Positive Regulation Of Cell Population Proliferation
DNA-templated Transcription
Regulation Of Programmed Cell Death
DNA Binding
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Signal Transduction
Intracellular Receptor Signaling Pathway
Cytosol
DNA-binding Transcription Factor Activity
Regulation Of Intracellular Signal Transduction
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cellular Developmental Process
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