NPAS2

Description		neuronal PAS domain protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol CLOCK-BMAL Transcription Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Protein Dimerization Activity Hsp90 Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Central Nervous System Development Response To Xenobiotic Stimulus Regulation Of Gene Expression Circadian Regulation Of Gene Expression Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Rhythmic Process Response To Redox State Positive Regulation Of Behavioral Fear Response
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Chronotype ( 30696823) Creutzfeldt-Jakob disease (variant) ( 22137330) Educational attainment ( 25201988) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 30054594 31798171 31959993) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Metabolite levels ( 23823483) Obsessive-compulsive traits ( 33531474) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) White blood cell count ( 32888494)
Interacting Genes		29 interacting genes: ARNT ARNT2 BMAL1 BPIFA1 CREBBP CRX CRY1 CRY2 CSNK2B DELEC1 EFS EP300 HESX1 HGS HSP90AA1 INCA1 KAT2B NCK2 NCOA3 NGLY1 RARA RASSF7 RHOXF1 RORC RPL6 RXRA TRAF4 UBAP2 ZSCAN1
Entrez ID		4862
HPRD ID		09137
Ensembl ID		ENSG00000170485
Uniprot IDs		A2I2P5 Q99743
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Transcription Regulator Complex Intracellular Receptor Signaling Pathway N-terminal Peptidyl-lysine Acetylation Nuclear Receptor Binding Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein-lysine-acetyltransferase Activity Regulation Of Metabolic Process Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of DNA-templated Transcription Aryl Hydrocarbon Receptor Binding Regulation Of RNA Biosynthetic Process Aryl Hydrocarbon Receptor Complex Rhythmic Process Histone Acetyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process N-terminal Protein Amino Acid Acetylation Positive Regulation Of Biosynthetic Process Peptidyl-lysine Acetylation Positive Regulation Of Macromolecule Metabolic Process Nuclear Receptor Activity DNA Binding Transcription Coregulator Activity Negative Regulation Of Transcription By RNA Polymerase II Histone H3K27 Acetyltransferase Activity Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Acetyltransferase Activity Hormone-mediated Signaling Pathway Circadian Regulation Of Gene Expression Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Modification Process
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