NPAS2 and HESX1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		NPAS2	HESX1
Description		neuronal PAS domain protein 2	HESX homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol CLOCK-BMAL Transcription Complex	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Protein Dimerization Activity Hsp90 Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Central Nervous System Development Response To Xenobiotic Stimulus Regulation Of Gene Expression Circadian Regulation Of Gene Expression Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Rhythmic Process Response To Redox State Positive Regulation Of Behavioral Fear Response	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Gonad Development Gene Expression Wnt Signaling Pathway Stem Cell Population Maintenance Pituitary Gland Development Thyroid Gland Development Forebrain Development Otic Vesicle Formation Multicellular Organism Growth Camera-type Eye Development Nose Development Negative Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Leukemia Inhibitory Factor Signaling Pathway Stem Cell Differentiation Canonical Wnt Signaling Pathway ERK1 And ERK2 Cascade Cellular Response To Cadmium Ion
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Drugs
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD) Septo-optic dysplasia
GWAS		Aspartate aminotransferase levels ( 33547301) Chronotype ( 30696823) Creutzfeldt-Jakob disease (variant) ( 22137330) Educational attainment ( 25201988) Hip circumference adjusted for BMI ( 34021172) Intraocular pressure ( 30054594 31798171 31959993) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Metabolite levels ( 23823483) Obsessive-compulsive traits ( 33531474) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) White blood cell count ( 32888494)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Family history of Alzheimer's disease ( 30617256)
Interacting Genes		29 interacting genes: ARNT ARNT2 BMAL1 BPIFA1 CREBBP CRX CRY1 CRY2 CSNK2B DELEC1 EFS EP300 HESX1 HGS HSP90AA1 INCA1 KAT2B NCK2 NCOA3 NGLY1 RARA RASSF7 RHOXF1 RORC RPL6 RXRA TRAF4 UBAP2 ZSCAN1	12 interacting genes: AIRIM CATIP GUCD1 HOXC8 KDM1A NCOR1 NPAS2 PRMT6 PROP1 STAT3 TLE1 UBL5
Entrez ID		4862	8820
HPRD ID		09137	03482
Ensembl ID		ENSG00000170485	ENSG00000163666
Uniprot IDs		A2I2P5 Q99743	Q9UBX0
PDB IDs			2K40
Enriched GO Terms of Interacting Partners?		Chromatin Transcription Regulator Complex Intracellular Receptor Signaling Pathway N-terminal Peptidyl-lysine Acetylation Nuclear Receptor Binding Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Protein-lysine-acetyltransferase Activity Regulation Of Metabolic Process Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Nuclear Protein Quality Control By The Ubiquitin-proteasome System Regulation Of DNA-templated Transcription Aryl Hydrocarbon Receptor Binding Regulation Of RNA Biosynthetic Process Aryl Hydrocarbon Receptor Complex Rhythmic Process Histone Acetyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process N-terminal Protein Amino Acid Acetylation Positive Regulation Of Biosynthetic Process Peptidyl-lysine Acetylation Positive Regulation Of Macromolecule Metabolic Process Nuclear Receptor Activity DNA Binding Transcription Coregulator Activity Negative Regulation Of Transcription By RNA Polymerase II Histone H3K27 Acetyltransferase Activity Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Acetyltransferase Activity Hormone-mediated Signaling Pathway Circadian Regulation Of Gene Expression Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Modification Process	Transcription Regulator Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of Glycolytic Process Nucleus Negative Regulation Of ATP Metabolic Process Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Regulation Of Androgen Receptor Signaling Pathway Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of RNA Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Glycolytic Process Histone H2AR3 Methyltransferase Activity Regulation Of Carbohydrate Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Behavior Hypophysis Morphogenesis Regulation Of ATP Metabolic Process Regulation Of MiRNA Transcription Negative Regulation Of Intracellular Signal Transduction Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Histone H3R2 Methyltransferase Activity Response To CAMP Regulation Of MiRNA Metabolic Process Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Negative Regulation Of Catabolic Process Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone Arginine N-methyltransferase Activity Negative Regulation Of Canonical NF-kappaB Signal Transduction Somatotropin Secreting Cell Differentiation RNA Sequestering Activity Protein Demethylase Activity
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