JAG2 and MIB2

Number of citations of the paper that reports this interaction (PubMedID 15920166)
28

Data Source:
BioGRID (pull down)

		JAG2	MIB2
Description		jagged canonical Notch ligand 2	MIB E3 ubiquitin protein ligase 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Ubiquitin Ligase Complex Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding Growth Factor Activity	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Skeletal System Development In Utero Embryonic Development Respiratory System Process Cell Communication Notch Signaling Pathway Spermatogenesis Auditory Receptor Cell Fate Commitment Morphogenesis Of Embryonic Epithelium Cell Differentiation Regulation Of Cell Adhesion T Cell Differentiation Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Gamma-delta T Cell Differentiation Thymic T Cell Selection Positive Regulation Of Notch Signaling Pathway Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis	Notch Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Positive Regulation Of Canonical NF-kappaB Signal Transduction
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling NOTCH3 Activation and Transmission of Signal to the Nucleus Antigen processing: Ubiquitination & Proteasome degradation PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Fasting plasma glucose ( 31932636) Red blood cell count ( 32888494)	Body mass index ( 26426971) Height ( 31562340) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295)
Interacting Genes		11 interacting genes: ATN1 ATXN7 CACNA1A GFI1B HOXA1 MBD1 MIB2 NOTCH1 NOTCH2 NOTCH3 SHANK3	13 interacting genes: ACTA1 ACTC1 BCL10 CYLD GRIN2B JAG2 SRPK2 TBK1 UBC UBE2D1 UBE2D2 UBE2N UBE2U
Entrez ID		3714	142678
HPRD ID		03981	15905
Ensembl ID		ENSG00000184916	ENSG00000197530
Uniprot IDs		Q9Y219	A0A8C8N694 A0A8C8USR6 E9PD12 Q96AX9
PDB IDs		5MW5 5MW7 5MWF
Enriched GO Terms of Interacting Partners?		Nuclear Matrix Cellular Response To Tumor Cell Notch Signaling Pathway Atrioventricular Node Development Glomerular Capillary Formation Artery Morphogenesis Negative Regulation Of Transcription By RNA Polymerase II Tube Morphogenesis Blood Vessel Morphogenesis Left/right Axis Specification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Ras Protein Signal Transduction Pulmonary Valve Morphogenesis Morphogenesis Of An Epithelial Sheet Regulation Of Transcription By RNA Polymerase II Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of RNA Metabolic Process Renal Tubule Development Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Inflammatory Response To Antigenic Stimulus Neuron Projection Development Neuron Fate Commitment Receptor Complex Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Projection Guidance Regulation Of Smooth Muscle Cell Differentiation Axon Guidance Regulation Of Ras Protein Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Semicircular Canal Formation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Coronary Sinus Valve Morphogenesis Foregut Morphogenesis Heart Valve Morphogenesis Positive Regulation Of MiRNA Transcription Futile Creatine Cycle Transcription Coactivator Activity Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Abducens Nerve Formation Optokinetic Behavior Cardiac Muscle Tissue Development	Ubiquitin Conjugating Enzyme Activity ATP Binding Nucleotide Binding Mesenchyme Migration Skeletal Muscle Thin Filament Assembly Protein Modification Process Negative Regulation Of TORC1 Signaling TORC1 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Post-translational Protein Modification TOR Signaling Negative Regulation Of TOR Signaling Protein Polyubiquitination Regulation Of TORC1 Signaling Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of T Cell Receptor Signaling Pathway Protein Ubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of Post-translational Protein Modification Myosin Binding Immune Response-activating Signaling Pathway Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Regulation Of TOR Signaling Regulation Of Protein Polyubiquitination Proteolysis Defense Response To Symbiont Immune Response-regulating Signaling Pathway Defense Response To Other Organism Pattern Recognition Receptor Signaling Pathway Intracellular Signal Transduction Activation Of Immune Response Innate Immune Response-activating Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Intracellular Signaling Cassette Regulation Of Protein Ubiquitination Peptidyl-serine Phosphorylation Response To Nutrient Levels Activation Of Innate Immune Response Negative Regulation Of Type I Interferon Production Negative Regulation Of Interleukin-18-mediated Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis Regulation Of T Cell Receptor Signaling Pathway Sarcomere Cytoplasmic Microtubule
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