JAG2

Description		jagged canonical Notch ligand 2
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GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding Growth Factor Activity
	Biological Process	Skeletal System Development In Utero Embryonic Development Respiratory System Process Cell Communication Notch Signaling Pathway Spermatogenesis Auditory Receptor Cell Fate Commitment Morphogenesis Of Embryonic Epithelium Cell Differentiation Regulation Of Cell Adhesion T Cell Differentiation Regulation Of Cell Population Proliferation Odontogenesis Of Dentin-containing Tooth Gamma-delta T Cell Differentiation Thymic T Cell Selection Positive Regulation Of Notch Signaling Pathway Epithelial Cell Apoptotic Process Involved In Palatal Shelf Morphogenesis
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Fasting plasma glucose ( 31932636) Red blood cell count ( 32888494)
Novel Interacting Genes		2 novel interacting genes: CKB KLC1
Interacting Genes		11 interacting genes: ATN1 ATXN7 CACNA1A GFI1B HOXA1 MBD1 MIB2 NOTCH1 NOTCH2 NOTCH3 SHANK3
Entrez ID		3714
HPRD ID		03981
Ensembl ID		ENSG00000184916
Uniprot IDs		Q9Y219
PDB IDs		5MW5 5MW7 5MWF
Enriched GO Terms of Interacting Partners?		Nuclear Matrix Cellular Response To Tumor Cell Notch Signaling Pathway Atrioventricular Node Development Glomerular Capillary Formation Artery Morphogenesis Negative Regulation Of Transcription By RNA Polymerase II Tube Morphogenesis Blood Vessel Morphogenesis Left/right Axis Specification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Ras Protein Signal Transduction Pulmonary Valve Morphogenesis Morphogenesis Of An Epithelial Sheet Regulation Of Transcription By RNA Polymerase II Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of RNA Metabolic Process Renal Tubule Development Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Inflammatory Response To Antigenic Stimulus Neuron Projection Development Neuron Fate Commitment Receptor Complex Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Projection Guidance Regulation Of Smooth Muscle Cell Differentiation Axon Guidance Regulation Of Ras Protein Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Semicircular Canal Formation Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Coronary Sinus Valve Morphogenesis Foregut Morphogenesis Heart Valve Morphogenesis Positive Regulation Of MiRNA Transcription Futile Creatine Cycle Transcription Coactivator Activity Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Abducens Nerve Formation Optokinetic Behavior Cardiac Muscle Tissue Development
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