NOS2 and ACTN4

Number of citations: 0 (PubMedID 12960352)
Data Source: HPRD (in vitro)

		NOS2	ACTN4
Name		nitric oxide synthase 2	actinin alpha 4
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Matrix Cytosol Plasma Membrane Cortical Cytoskeleton Perinuclear Region Of Cytoplasm	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction Postsynaptic Actin Cytoskeleton Ribonucleoprotein Complex
	Molecular Function	Nitric-oxide Synthase Activity Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Leukocyte Mediated Cytotoxicity Innate Immune Response In Mucosa L-arginine Catabolic Process Superoxide Metabolic Process Nitric Oxide Biosynthetic Process Inflammatory Response Nitric Oxide Mediated Signal Transduction Circadian Rhythm Response To Bacterium Response To Hormone Negative Regulation Of Gene Expression Peptidyl-cysteine S-nitrosylation Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Population Proliferation Negative Regulation Of Protein Catabolic Process Defense Response To Bacterium Regulation Of Cellular Respiration Cell Redox Homeostasis Negative Regulation Of Blood Pressure Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Xenobiotic Stimulus Regulation Of Cytokine Production Involved In Inflammatory Response	Protein Transport Actin Cytoskeleton Organization Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Muscle Cell Development Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		ROS and RNS production in phagocytes Nitric oxide stimulates guanylate cyclase Interleukin-4 and Interleukin-13 signaling Peroxisomal protein import Peroxisomal protein import Inhibition of nitric oxide production	Platelet degranulation Nephrin family interactions
Drugs		Arginine Citrulline Mesalazine Minocycline Miconazole Dexamethasone Ginkgo biloba N,N-dimethylarginine 4R-Fluoro-N6-ethanimidoyl-L-lysine 3-Bromo-7-Nitroindazole N-[3-(aminomethyl)benzyl]acetamidine 7-Nitroindazole S-Ethylisothiourea Thiocoumarin N-omega-propyl-L-arginine 6-Nitroindazole N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine Imidazole N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide Thiocitrulline L-erythro-7,8-dihydrobiopterin 5-Nitroindazole KD7040 Fenoxaprop-ethyl Pimagedine 5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE 4-(1H-IMIDAZOL-1-YL)PHENOL 1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINE Triflusal Levamlodipine Dipyrithione Dexamethasone acetate	None
Diseases		Esophageal cancer	Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107 ) Ankylosing spondylitis ( 23749187 30946743 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 23128233 ) Cutaneous psoriasis ( 26626624 ) Fractional exhaled nitric oxide (childhood) ( 24315451 ) Inflammatory skin disease ( 25574825 ) Psoriasis ( 20953189 23143594 25903422 ) Psoriasis vulgaris ( 26626624 ) Psoriatic arthritis ( 26626624 )	Brain morphology (MOSTest) ( 32665545 ) Fasting glucose ( 34074324 ) Heart rate ( 23583979 ) Immature fraction of reticulocytes ( 32888494 ) Logical memory (immediate recall) in mild cognitive impairment ( 29274321 ) Mean platelet volume ( 32888494 ) Retinal venular tortuosity ( 31597446 ) Waist circumference ( 28552196 )
Novel Interactors		3 novel interactors: AATF AP2B1 CSF3	None recorded
Interacting Genes		11 interacting genes: ACTB ACTN4 CAV1 NHERF1 PEX5 RAC1 RAC2 SPSB1 SPSB2 SPSB4 SRC	60 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A CEBPA COIL COL17A1 DDIAS DSCAM DSCR9 ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NHERF2 NOS2 NOS3 PDE4B PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RNF10 RPS27 SACS SERPINE1 SLC2A4 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR
Entrez ID		4843	81
HPRD ID		01225	05222
Ensembl ID		ENSG00000007171	ENSG00000130402
Uniprot IDs		P35228	A0A0S2Z3G9 F5GXS2 H7C144 O43707
PDB IDs		1NSI 2LL6 2NSI 3E7G 3EJ8 3HR4 4CX7 4NOS 5TP6 5XN3 6JWM 6JWN 6KEY	1WLX 1YDI 2R0O 6O31 6OA6
GO Terms Enriched among Interactors		Actin Filament-based Process Focal Adhesion Actin Cytoskeleton Organization Actin Filament Angiotensin-activated Signaling Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Lamellipodium Organization Regulation Of Endocytosis Erythrocyte Enucleation Establishment Or Maintenance Of Cell Polarity Regulation Of Transport Regulation Of Lamellipodium Organization Anatomical Structure Homeostasis Tissue Homeostasis Enzyme Binding SCF Ubiquitin Ligase Complex Regulation Of Cell Adhesion Regulation Of Cell-substrate Adhesion Postsynaptic Actin Cytoskeleton Regulation Of Cell Projection Assembly Nitric-oxide Synthase Binding Regulation Of Cellular Localization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Morphogenesis Negative Regulation Of Fibroblast Migration Positive Regulation Of Cell Migration Cytoskeleton Organization Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Hydrogen Peroxide Metabolic Process NADPH Oxidase Complex Ubiquitin-like Ligase-substrate Adaptor Activity Positive Regulation Of Locomotion Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Motility Protein Localization To Membrane Regulation Of Protein Modification Process Negative Regulation Of Anoikis Regulation Of Respiratory Burst Regulation Of Locomotion Respiratory Burst Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Superoxide Anion Generation Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Neutrophil Chemotaxis Cellular Component Assembly Transmembrane Transporter Binding Positive Regulation Of Protein Modification Process Regulation Of Actin Filament-based Process	Z Disc Actomyosin Structure Organization Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Calmodulin Binding Actin Cytoskeleton Organization Actin Cytoskeleton Positive Regulation Of Metabolic Process Developmental Process Cytoplasm Actin Filament-based Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Calcium- And Calmodulin-dependent Protein Kinase Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Calcium-mediated Signaling Regulation Of Macromolecule Biosynthetic Process Telethonin Binding Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication Myofibril Assembly Protein Kinase Binding Anatomical Structure Formation Involved In Morphogenesis Cytoskeleton Organization Actin Binding Anatomical Structure Morphogenesis Regulation Of Skeletal Muscle Adaptation Supramolecular Fiber Organization Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Cytokine Production Sarcomere Organization Regulation Of Calcium Ion Transport Actinin Binding Circulatory System Process Structural Constituent Of Muscle Regulation Of Angiogenesis Cardiac Myofibril Assembly Alpha-actinin Binding Negative Regulation Of Developmental Process