NOS2 and SPSB4

Number of citations of the paper that reports this interaction (PMID 20603330)
17

Data Source:
BioGRID (pull down)

		NOS2	SPSB4
Gene Name		nitric oxide synthase 2, inducible	splA/ryanodine receptor domain and SOCS box containing 4
Image
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Cytoplasm Peroxisome Cytosol Cortical Cytoskeleton Perinuclear Region Of Cytoplasm	Cytoplasm
	Molecular Function	NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Receptor Binding Iron Ion Binding Protein Binding Calmodulin Binding FMN Binding Heme Binding Tetrahydrobiopterin Binding Arginine Binding Protein Homodimerization Activity Flavin Adenine Dinucleotide Binding NADP Binding	Protein Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Leukocyte Mediated Cytotoxicity Innate Immune Response In Mucosa Arginine Catabolic Process Superoxide Metabolic Process Nitric Oxide Biosynthetic Process Inflammatory Response Nitric Oxide Mediated Signal Transduction Blood Coagulation Circadian Rhythm Response To Bacterium Negative Regulation Of Gene Expression Peptidyl-cysteine S-nitrosylation Positive Regulation Of Guanylate Cyclase Activity Regulation Of Cell Proliferation Negative Regulation Of Protein Catabolic Process Defense Response To Bacterium Regulation Of Cellular Respiration Negative Regulation Of Blood Pressure Positive Regulation Of Vasodilation Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Interaction With Host Positive Regulation Of Killing Of Cells Of Other Organism Oxidation-reduction Process Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Phagosome Maturation	Protein Ubiquitination Intracellular Signal Transduction
Pathways		Platelet homeostasis Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Nitric oxide stimulates guanylate cyclase	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs		L-Arginine L-Citrulline Miconazole Dexamethasone N,N-dimethylarginine 4r-Fluoro-N6-Ethanimidoyl-L-Lysine 3-Bromo-7-Nitroindazole N-(3-(Aminomethyl)Benzyl)Acetamidine 7-Nitroindazole Ethylisothiourea Thiocoumarin Aminoguanidine S-Ethylisothiourea N-Omega-Propyl-L-Arginine (6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin Heme 6-Nitroindazole N-Omega-Hydroxy-L-Arginine 7,8-Dihydro-L-Biopterin N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine L-Thiocitrulline 7,8-Dihydrobiopterin 5-Nitroindazole 5-(4\'-AMINO-1\'-ETHYL-5\',8\'-DIFLUORO-1\'H-SPIRO[PIPERIDINE-4,2\'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE 1-(6-CYANO-3-PYRIDYLCARBONYL)-5\',8\'-DIFLUOROSPIRO[PIPERIDINE-4,2\'(1\'H)-QUINAZOLINE]-4\'-AMINE 4-(1H-IMIDAZOL-1-YL)PHENOL 1-[4-(AMINOMETHYL)BENZOYL]-5\'-FLUORO-1\'H-SPIRO[PIPERIDINE-4,2\'-QUINAZOLIN]-4\'-AMINE Triflusal
Diseases
GWAS		Crohn's disease ( 23128233) Psoriasis ( 20953189)	Stroke (ischemic) ( 23041239)
Protein-Protein Interactions		11 interactors: ACTB ACTN4 CAV1 PEX5 RAC1 RAC2 SLC9A3R1 SPSB1 SPSB2 SPSB4 SRC	3 interactors: DDX4 NOS2 PAWR
Entrez ID		4843	92369
HPRD ID		01225	18108
Ensembl ID		ENSG00000007171	ENSG00000175093
Uniprot IDs		P35228	Q96A44
PDB IDs		1NSI 2LL6 2NSI 3E7G 3EJ8 3HR4 4NOS	2V24
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Platelet Activation Regulation Of Body Fluid Levels Vascular Endothelial Growth Factor Receptor Signaling Pathway Wound Healing Tissue Remodeling Cellular Component Assembly Regulation Of Cellular Component Movement Response To Wounding Bone Resorption Tissue Homeostasis Regulation Of Endocytosis Cell-cell Junction Organization Bone Remodeling Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Protein Homooligomerization Signal Transduction Multicellular Organismal Homeostasis Actin Cytoskeleton Organization Intracellular Signal Transduction Signaling T Cell Costimulation Actin Filament-based Process Cell Communication Negative Regulation Of Protein Oligomerization Cell Activation Locomotion Actin Filament Organization Regulation Of Hydrogen Peroxide Metabolic Process Organelle Organization Ephrin Receptor Signaling Pathway Regulation Of Respiratory Burst Homeostatic Process Positive Regulation Of Cellular Component Movement Regulation Of Proton Transport Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Anoikis Regulation Of Vesicle-mediated Transport Regulation Of Cell Projection Assembly Movement Of Cell Or Subcellular Component Axon Guidance Membrane Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Lamellipodium Organization Regulation Of Anoikis Positive Regulation Of Immune System Process Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity	Positive Regulation Of Amyloid Precursor Protein Biosynthetic Process Peptidyl-cysteine S-nitrosylation Interleukin-2 Biosynthetic Process Germ-line Stem Cell Maintenance Regulation Of Amyloid Precursor Protein Biosynthetic Process Interleukin-2 Production Arginine Catabolic Process Positive Regulation Of Killing Of Cells Of Other Organism Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Guanylate Cyclase Activity Spermatogenesis Male Gamete Generation Regulation Of Cellular Respiration Positive Regulation Of Glycoprotein Biosynthetic Process Nitric Oxide Biosynthetic Process Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Glycoprotein Metabolic Process Nitric Oxide Mediated Signal Transduction Negative Regulation Of B Cell Proliferation Innate Immune Response In Mucosa Positive Regulation Of CGMP Biosynthetic Process Gamete Generation Positive Regulation Of CGMP Metabolic Process Organelle Organization Arginine Metabolic Process Negative Regulation Of T Cell Receptor Signaling Pathway RNA Metabolic Process Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Meiotic Nuclear Division Regulation Of CGMP Biosynthetic Process Cytokine Biosynthetic Process Regulation Of Protein Localization Sexual Reproduction Regulation Of Glycoprotein Biosynthetic Process Multicellular Organismal Reproductive Process Negative Regulation Of Meiotic Cell Cycle Nitric Oxide Metabolic Process Male Meiosis I Multicellular Organism Reproduction Cytokine Metabolic Process Reactive Nitrogen Species Metabolic Process Regulation Of CGMP Metabolic Process Positive Regulation Of Vasodilation Mucosal Immune Response PiRNA Metabolic Process Defense Response To Gram-negative Bacterium Negative Regulation Of B Cell Activation Superoxide Metabolic Process Regulation Of Meiosis Reproduction
Tagcloud ?		17q 2q35 5p 6p 9p bcg candidates demonstration dichotomy exacerbation examines helper histocompatibility il4 immunology inbred ity leishmania leishmanial leishmaniasis lsh mexicana mip1 nramp1 parasites pleiotropic positionally reflecting sigje
Tagcloud (Difference) ?		17q 2q35 5p 6p 9p bcg candidates demonstration dichotomy exacerbation examines helper histocompatibility il4 immunology inbred ity leishmania leishmanial leishmaniasis lsh mexicana mip1 nramp1 parasites pleiotropic positionally reflecting sigje
Tagcloud (Intersection) ?