NOS2 and SPSB4

Number of citations of the paper that reports this interaction (PubMedID 20603330)
66

Data Source:
BioGRID (pull down)

		NOS2	SPSB4
Description		nitric oxide synthase 2	splA/ryanodine receptor domain and SOCS box containing 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Peroxisome Peroxisomal Matrix Cytosol Plasma Membrane Cortical Cytoskeleton Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Nitric-oxide Synthase Activity Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Protein Homodimerization Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding NADP Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Leukocyte Mediated Cytotoxicity Innate Immune Response In Mucosa L-arginine Catabolic Process Superoxide Metabolic Process Nitric Oxide Biosynthetic Process Inflammatory Response Nitric Oxide Mediated Signal Transduction Circadian Rhythm Response To Bacterium Response To Hormone Negative Regulation Of Gene Expression Peptidyl-cysteine S-nitrosylation Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Population Proliferation Negative Regulation Of Protein Catabolic Process Defense Response To Bacterium Regulation Of Cellular Respiration Cell Redox Homeostasis Negative Regulation Of Blood Pressure Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Xenobiotic Stimulus Regulation Of Cytokine Production Involved In Inflammatory Response	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Circadian Rhythm Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Rhythmic Process Positive Regulation Of Protein Polyubiquitination
Pathways		ROS and RNS production in phagocytes Nitric oxide stimulates guanylate cyclase Interleukin-4 and Interleukin-13 signaling Peroxisomal protein import Peroxisomal protein import Inhibition of nitric oxide production	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Arginine Citrulline Mesalazine Minocycline Miconazole Dexamethasone Ginkgo biloba N,N-dimethylarginine 4R-Fluoro-N6-ethanimidoyl-L-lysine 3-Bromo-7-Nitroindazole N-[3-(aminomethyl)benzyl]acetamidine 7-Nitroindazole S-Ethylisothiourea Thiocoumarin N-omega-propyl-L-arginine 6-Nitroindazole N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine Imidazole N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide Thiocitrulline L-erythro-7,8-dihydrobiopterin 5-Nitroindazole KD7040 Fenoxaprop-ethyl Pimagedine 5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE 4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE (3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE 4-(1H-IMIDAZOL-1-YL)PHENOL 1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINE Triflusal Levamlodipine Dipyrithione Dexamethasone acetate
Diseases		Esophageal cancer
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Ankylosing spondylitis ( 23749187 30946743) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 23128233) Cutaneous psoriasis ( 26626624) Fractional exhaled nitric oxide (childhood) ( 24315451) Inflammatory skin disease ( 25574825) Psoriasis ( 20953189 23143594 25903422) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624)	Ischemic stroke ( 24262325) Response to citalopram or escitalopram in depression ( 27622933) Schizophrenia x sex interaction ( 34099189) Stroke (ischemic) ( 23041239)
Interacting Genes		11 interacting genes: ACTB ACTN4 CAV1 NHERF1 PEX5 RAC1 RAC2 SPSB1 SPSB2 SPSB4 SRC	2 interacting genes: DDX4 NOS2
Entrez ID		4843	92369
HPRD ID		01225	18108
Ensembl ID		ENSG00000007171	ENSG00000175093
Uniprot IDs		P35228	Q96A44
PDB IDs		1NSI 2LL6 2NSI 3E7G 3EJ8 3HR4 4CX7 4NOS 5TP6 5XN3 6JWM 6JWN 6KEY	2V24 6DN7 6DN8
Enriched GO Terms of Interacting Partners?		Actin Filament-based Process Focal Adhesion Actin Cytoskeleton Organization Actin Filament Angiotensin-activated Signaling Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Lamellipodium Organization Regulation Of Endocytosis Erythrocyte Enucleation Establishment Or Maintenance Of Cell Polarity Regulation Of Transport Regulation Of Lamellipodium Organization Anatomical Structure Homeostasis Tissue Homeostasis Enzyme Binding SCF Ubiquitin Ligase Complex Regulation Of Cell Adhesion Regulation Of Cell-substrate Adhesion Postsynaptic Actin Cytoskeleton Regulation Of Cell Projection Assembly Nitric-oxide Synthase Binding Regulation Of Cellular Localization Positive Regulation Of Cellular Component Biogenesis Regulation Of Cell Morphogenesis Negative Regulation Of Fibroblast Migration Positive Regulation Of Cell Migration Cytoskeleton Organization Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Hydrogen Peroxide Metabolic Process NADPH Oxidase Complex Ubiquitin-like Ligase-substrate Adaptor Activity Positive Regulation Of Locomotion Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Motility Protein Localization To Membrane Regulation Of Protein Modification Process Negative Regulation Of Anoikis Regulation Of Respiratory Burst Regulation Of Locomotion Respiratory Burst Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Superoxide Anion Generation Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Neutrophil Chemotaxis Cellular Component Assembly Transmembrane Transporter Binding Positive Regulation Of Protein Modification Process Regulation Of Actin Filament-based Process	Nitric-oxide Synthase Activity Peptidyl-cysteine S-nitrosylation Tetrahydrobiopterin Binding Prostaglandin Secretion Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation PiP-body Arginine Metabolic Process L-arginine Catabolic Process Perinuclear Region Of Cytoplasm Innate Immune Response In Mucosa Lipid Export From Cell Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Nitric Oxide Mediated Signal Transduction FMN Binding Arginine Binding Prostaglandin Transport Nitric Oxide Biosynthetic Process Pi-body Transposable Element Silencing By PiRNA-mediated DNA Methylation Regulatory NcRNA-mediated Heterochromatin Formation PiRNA Processing P Granule Transposable Element Silencing By Heterochromatin Formation Fc Receptor Mediated Stimulatory Signaling Pathway Male Meiosis I Cortical Cytoskeleton Mucosal Immune Response Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Organ Or Tissue Specific Immune Response Fc-gamma Receptor Signaling Pathway NADP Binding Negative Regulation Of Gene Expression Transposable Element Silencing Meiosis I DNA Methylation-dependent Constitutive Heterochromatin Formation Cell Redox Homeostasis Regulation Of Cellular Respiration Superoxide Metabolic Process Negative Regulation Of Blood Pressure Peroxisomal Matrix Male Meiotic Nuclear Division Molecular Condensate Scaffold Activity Fc Receptor Signaling Pathway Constitutive Heterochromatin Formation Glutamine Family Amino Acid Metabolic Process Flavin Adenine Dinucleotide Binding Positive Regulation Of Interleukin-8 Production Cellular Response To Xenobiotic Stimulus Positive Regulation Of Leukocyte Mediated Cytotoxicity
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