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NOS2
Description
nitric oxide synthase 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Peroxisome
Peroxisomal Matrix
Cytosol
Plasma Membrane
Cortical Cytoskeleton
Perinuclear Region Of Cytoplasm
Molecular Function
Nitric-oxide Synthase Activity
Protein Binding
Calmodulin Binding
FMN Binding
Oxidoreductase Activity
Heme Binding
Tetrahydrobiopterin Binding
Arginine Binding
Protein Homodimerization Activity
Metal Ion Binding
Flavin Adenine Dinucleotide Binding
NADP Binding
Biological Process
Response To Hypoxia
Positive Regulation Of Leukocyte Mediated Cytotoxicity
Innate Immune Response In Mucosa
L-arginine Catabolic Process
Superoxide Metabolic Process
Nitric Oxide Biosynthetic Process
Inflammatory Response
Nitric Oxide Mediated Signal Transduction
Circadian Rhythm
Response To Bacterium
Response To Hormone
Negative Regulation Of Gene Expression
Peptidyl-cysteine S-nitrosylation
Prostaglandin Secretion
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Cell Population Proliferation
Negative Regulation Of Protein Catabolic Process
Defense Response To Bacterium
Regulation Of Cellular Respiration
Cell Redox Homeostasis
Negative Regulation Of Blood Pressure
Regulation Of Insulin Secretion
Defense Response To Gram-negative Bacterium
Cellular Response To Lipopolysaccharide
Cellular Response To Type II Interferon
Cellular Response To Xenobiotic Stimulus
Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways
ROS and RNS production in phagocytes
Nitric oxide stimulates guanylate cyclase
Interleukin-4 and Interleukin-13 signaling
Peroxisomal protein import
Peroxisomal protein import
Inhibition of nitric oxide production
Drugs
Arginine
Citrulline
Mesalazine
Minocycline
Miconazole
Dexamethasone
Ginkgo biloba
N,N-dimethylarginine
4R-Fluoro-N6-ethanimidoyl-L-lysine
3-Bromo-7-Nitroindazole
N-[3-(aminomethyl)benzyl]acetamidine
7-Nitroindazole
S-Ethylisothiourea
Thiocoumarin
N-omega-propyl-L-arginine
6-Nitroindazole
N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine
Imidazole
N-(4-{2-[(3-chlorobenzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide
Thiocitrulline
L-erythro-7,8-dihydrobiopterin
5-Nitroindazole
KD7040
Fenoxaprop-ethyl
Pimagedine
5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE
N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE
4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile
(2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine
(3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine
4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE
(3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE
4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE
ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE
ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE
1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE
4-(1H-IMIDAZOL-1-YL)PHENOL
1-[4-(AMINOMETHYL)BENZOYL]-5'-FLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLIN]-4'-AMINE
Triflusal
Levamlodipine
Dipyrithione
Dexamethasone acetate
Diseases
Esophageal cancer
GWAS
Acute anterior uveitis in ankylosing spondylitis (
32492107
)
Ankylosing spondylitis (
23749187
30946743
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
23128233
)
Cutaneous psoriasis (
26626624
)
Fractional exhaled nitric oxide (childhood) (
24315451
)
Inflammatory skin disease (
25574825
)
Psoriasis (
20953189
23143594
25903422
)
Psoriasis vulgaris (
26626624
)
Psoriatic arthritis (
26626624
)
Novel Interacting Genes
3 novel interacting genes:
AATF
AP2B1
CSF3
Interacting Genes
11 interacting genes:
ACTB
ACTN4
CAV1
NHERF1
PEX5
RAC1
RAC2
SPSB1
SPSB2
SPSB4
SRC
Entrez ID
4843
HPRD ID
01225
Ensembl ID
ENSG00000007171
Uniprot IDs
P35228
PDB IDs
1NSI
2LL6
2NSI
3E7G
3EJ8
3HR4
4CX7
4NOS
5TP6
5XN3
6JWM
6JWN
6KEY
Enriched GO Terms of Interacting Partners
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Actin Filament-based Process
Focal Adhesion
Actin Cytoskeleton Organization
Actin Filament
Angiotensin-activated Signaling Pathway
Regulation Of Vesicle-mediated Transport
Positive Regulation Of Lamellipodium Organization
Regulation Of Endocytosis
Erythrocyte Enucleation
Establishment Or Maintenance Of Cell Polarity
Regulation Of Transport
Regulation Of Lamellipodium Organization
Anatomical Structure Homeostasis
Tissue Homeostasis
Enzyme Binding
SCF Ubiquitin Ligase Complex
Regulation Of Cell Adhesion
Regulation Of Cell-substrate Adhesion
Postsynaptic Actin Cytoskeleton
Regulation Of Cell Projection Assembly
Nitric-oxide Synthase Binding
Regulation Of Cellular Localization
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Cell Morphogenesis
Negative Regulation Of Fibroblast Migration
Positive Regulation Of Cell Migration
Cytoskeleton Organization
Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Regulation Of Hydrogen Peroxide Metabolic Process
NADPH Oxidase Complex
Ubiquitin-like Ligase-substrate Adaptor Activity
Positive Regulation Of Locomotion
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Cell Motility
Protein Localization To Membrane
Regulation Of Protein Modification Process
Negative Regulation Of Anoikis
Regulation Of Respiratory Burst
Regulation Of Locomotion
Respiratory Burst
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Intracellular Signal Transduction
Superoxide Anion Generation
Regulation Of Synaptic Vesicle Endocytosis
Positive Regulation Of Neutrophil Chemotaxis
Cellular Component Assembly
Transmembrane Transporter Binding
Positive Regulation Of Protein Modification Process
Regulation Of Actin Filament-based Process
Tagcloud
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