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NOS2
Gene Name
nitric oxide synthase 2, inducible
Image
Gene Ontology Annotations
Cellular Component
Intracellular
Nucleus
Cytoplasm
Peroxisome
Cytosol
Cortical Cytoskeleton
Perinuclear Region Of Cytoplasm
Molecular Function
NADPH-hemoprotein Reductase Activity
Nitric-oxide Synthase Activity
Receptor Binding
Iron Ion Binding
Protein Binding
Calmodulin Binding
FMN Binding
Heme Binding
Tetrahydrobiopterin Binding
Arginine Binding
Protein Homodimerization Activity
Flavin Adenine Dinucleotide Binding
NADP Binding
Biological Process
Response To Hypoxia
Positive Regulation Of Leukocyte Mediated Cytotoxicity
Innate Immune Response In Mucosa
Arginine Catabolic Process
Superoxide Metabolic Process
Nitric Oxide Biosynthetic Process
Inflammatory Response
Nitric Oxide Mediated Signal Transduction
Blood Coagulation
Circadian Rhythm
Response To Bacterium
Negative Regulation Of Gene Expression
Peptidyl-cysteine S-nitrosylation
Positive Regulation Of Guanylate Cyclase Activity
Regulation Of Cell Proliferation
Negative Regulation Of Protein Catabolic Process
Defense Response To Bacterium
Regulation Of Cellular Respiration
Negative Regulation Of Blood Pressure
Positive Regulation Of Vasodilation
Regulation Of Insulin Secretion
Defense Response To Gram-negative Bacterium
Interaction With Host
Positive Regulation Of Killing Of Cells Of Other Organism
Oxidation-reduction Process
Cellular Response To Lipopolysaccharide
Cellular Response To Interferon-gamma
Phagosome Maturation
Pathways
Platelet homeostasis
Phagosomal maturation (early endosomal stage)
Latent infection of Homo sapiens with Mycobacterium tuberculosis
Nitric oxide stimulates guanylate cyclase
Drugs
L-Arginine
L-Citrulline
Miconazole
Dexamethasone
N,N-dimethylarginine
4r-Fluoro-N6-Ethanimidoyl-L-Lysine
3-Bromo-7-Nitroindazole
N-(3-(Aminomethyl)Benzyl)Acetamidine
7-Nitroindazole
Ethylisothiourea
Thiocoumarin
Aminoguanidine
S-Ethylisothiourea
N-Omega-Propyl-L-Arginine
(6r,1\'r,2\'s)-5,6,7,8 Tetrahydrobiopterin
Heme
6-Nitroindazole
N-Omega-Hydroxy-L-Arginine
7,8-Dihydro-L-Biopterin
N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine
L-Thiocitrulline
7,8-Dihydrobiopterin
5-Nitroindazole
5-(4\'-AMINO-1\'-ETHYL-5\',8\'-DIFLUORO-1\'H-SPIRO[PIPERIDINE-4,2\'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE
N-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-1-[2-(1H-IMIDAZOL-1-YL)-6-METHYLPYRIMIDIN-4-YL]-D-PROLINAMIDE
4-({4-[(4-methoxypyridin-2-yl)amino]piperidin-1-yl}carbonyl)benzonitrile
(2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine
(3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine
4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE
(3S)-1-(1,3-BENZODIOXOL-5-YLMETHYL)-3-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PIPERIDINE
4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-6-METHYLPYRIMIDINE
ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE
ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
N-[2-(6-AMINO-4-METHYLPYRIDIN-2-YL)ETHYL]-4-CYANOBENZAMIDE
1-(6-CYANO-3-PYRIDYLCARBONYL)-5\',8\'-DIFLUOROSPIRO[PIPERIDINE-4,2\'(1\'H)-QUINAZOLINE]-4\'-AMINE
4-(1H-IMIDAZOL-1-YL)PHENOL
1-[4-(AMINOMETHYL)BENZOYL]-5\'-FLUORO-1\'H-SPIRO[PIPERIDINE-4,2\'-QUINAZOLIN]-4\'-AMINE
Triflusal
Diseases
GWAS
Crohn's disease (
23128233
)
Psoriasis (
20953189
)
Protein-protein Interactions
11 interactors:
ACTB
ACTN4
CAV1
PEX5
RAC1
RAC2
SLC9A3R1
SPSB1
SPSB2
SPSB4
SRC
Entrez ID
4843
HPRD ID
01225
Ensembl ID
ENSG00000007171
Uniprot IDs
P35228
PDB IDs
1NSI
2LL6
2NSI
3E7G
3EJ8
3HR4
4NOS
Enriched GO Terms of Interacting Partners
?
Blood Coagulation
Hemostasis
Platelet Activation
Regulation Of Body Fluid Levels
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Wound Healing
Tissue Remodeling
Cellular Component Assembly
Regulation Of Cellular Component Movement
Response To Wounding
Bone Resorption
Tissue Homeostasis
Regulation Of Endocytosis
Cell-cell Junction Organization
Bone Remodeling
Regulation Of Sodium:proton Antiporter Activity
Negative Regulation Of Protein Homooligomerization
Signal Transduction
Multicellular Organismal Homeostasis
Actin Cytoskeleton Organization
Intracellular Signal Transduction
Signaling
T Cell Costimulation
Actin Filament-based Process
Cell Communication
Negative Regulation Of Protein Oligomerization
Cell Activation
Locomotion
Actin Filament Organization
Regulation Of Hydrogen Peroxide Metabolic Process
Organelle Organization
Ephrin Receptor Signaling Pathway
Regulation Of Respiratory Burst
Homeostatic Process
Positive Regulation Of Cellular Component Movement
Regulation Of Proton Transport
Positive Regulation Of Lamellipodium Assembly
Negative Regulation Of Anoikis
Regulation Of Vesicle-mediated Transport
Regulation Of Cell Projection Assembly
Movement Of Cell Or Subcellular Component
Axon Guidance
Membrane Organization
Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Cellular Response To Stimulus
Positive Regulation Of Lamellipodium Organization
Regulation Of Anoikis
Positive Regulation Of Immune System Process
Regulation Of Ion Transmembrane Transporter Activity
Regulation Of Transmembrane Transporter Activity
Tagcloud
?
17q
2q35
5p
6p
9p
bcg
candidates
demonstration
dichotomy
exacerbation
examines
helper
histocompatibility
il4
immunology
inbred
ity
leishmania
leishmanial
leishmaniasis
lsh
mexicana
mip1
nramp1
parasites
pleiotropic
positionally
reflecting
sigje