NMB and NMBR

Number of citations: 0 (PubMedID 8392057)
Data Source: HPRD (in vivo)

		NMB	NMBR
Name		neuromedin B	neuromedin B receptor
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Projection Neuron Projection	Cytosol Plasma Membrane Membrane
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding Neuromedin B Receptor Binding	G Protein-coupled Receptor Activity Bombesin Receptor Activity Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity
	Biological Process	Immune System Process Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interferon-alpha Production Innate Immune Response Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Arachidonate Secretion Positive Regulation Of Osteoclast Proliferation Antiviral Innate Immune Response Sneeze Reflex Leydig Cell Proliferation Sensory Perception Of Itch Positive Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Testosterone Secretion	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Bombesin Receptor Signaling Pathway Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Osteoclast Proliferation Antiviral Innate Immune Response Sneeze Reflex Positive Regulation Of Respiratory Gaseous Exchange
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 31043756 ) Blood protein levels ( 30072576 ) Creatine kinase levels ( 29403010 ) Dilated cardiomyopathy ( 33495596 ) Dilated cardiomyopathy (MTAG) ( 33495596 ) P wave terminal force ( 28794112 ) Schizophrenia ( 29483656 )	Alanine aminotransferase levels ( 33547301 ) Birth weight ( 31043758 ) Body size at age 10 ( 32376654 ) Height ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Retinal vascular caliber ( 21060863 ) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415 )
Novel Interactors		8 novel interactors: CCNO CORO2B FBXL22 GLCE KIF23 MAP2K5 MRPS5 PTPRZ1	None recorded
Interacting Genes		4 interacting genes: BIRC2 GADD45G NMBR TPP1	1 interacting genes: NMB
Entrez ID		4828	4829
HPRD ID		01210	01211
Ensembl ID		ENSG00000197696	ENSG00000135577
Uniprot IDs		P08949	P28336
PDB IDs		1C98 1C9A 8H0P	8H0P
GO Terms Enriched among Interactors		None	Sensory Perception Of Itch Sneeze Reflex Positive Regulation Of Testosterone Secretion Neuromedin B Receptor Binding Positive Regulation Of Osteoclast Proliferation Leydig Cell Proliferation Positive Regulation Of Respiratory Gaseous Exchange Reflex Positive Regulation Of Interferon-alpha Production Arachidonate Secretion Regulation Of Respiratory Gaseous Exchange Neuropeptide Hormone Activity Negative Regulation Of Interleukin-6 Production Long-chain Fatty Acid Transport Negative Regulation Of Hormone Secretion Antiviral Innate Immune Response Positive Regulation Of Lipid Transport Fatty Acid Transport Positive Regulation Of Type I Interferon Production Neuropeptide Signaling Pathway Hormone Activity Regulation Of Type I Interferon Production Monocarboxylic Acid Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Secretion By Cell Regulation Of Lipid Transport Positive Regulation Of Hormone Secretion Regulation Of Interleukin-6 Production Negative Regulation Of Secretion Positive Regulation Of Leukocyte Proliferation Regulation Of Hormone Secretion Carboxylic Acid Transport Organic Acid Transport Regulation Of Leukocyte Proliferation Defense Response To Virus