NMB and NMBR

Number of citations of the paper that reports this interaction (PMID 8392057)
9

Data Source:
HPRD (in vivo)

		NMB	NMBR
Gene Name		neuromedin B	neuromedin B receptor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Neuron Projection	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Hormone Activity Neuromedin B Receptor Binding	Bombesin Receptor Activity
	Biological Process	Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Glucose Homeostasis Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Arachidonic Acid Secretion	G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Bombesin Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Retinal vascular caliber ( 21060863)
Protein-Protein Interactions		3 interactors: BIRC2 NMBR TPP1	1 interactors: NMB
Entrez ID		4828	4829
HPRD ID		01210	01211
Ensembl ID		ENSG00000197696	ENSG00000135577
Uniprot IDs		P08949	P28336
PDB IDs		1C98 1C9A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Negative Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Single-stranded Telomeric DNA Binding Placenta Development Regulation Of Establishment Of Blood-brain Barrier Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Intermembrane Transport Bombesin Receptor Signaling Pathway Regulation Of Protein Monoubiquitination Vitamin E Metabolic Process Protection From Non-homologous End Joining At Telomere Telomere Capping Protein Localization To Chromosome, Telomeric Region Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity Telomere Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Telomere Maintenance Reproductive Structure Development Reproductive System Development Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Necroptotic Process Peptide Catabolic Process Negative Regulation Of Necrotic Cell Death Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Regulation Of Telomerase Activity Protein Catabolic Process Regulation Of Telomere Maintenance Intracellular PH Reduction Positive Regulation Of DNA Biosynthetic Process Regulation Of Necrotic Cell Death Developmental Process Involved In Reproduction PH Reduction Necroptotic Process Protein Localization To Chromosome Positive Regulation Of Protein Modification Process Bone Resorption Response To PH Positive Regulation Of DNA Binding Negative Regulation Of Cell Death Regulation Of Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Programmed Necrotic Cell Death Necrotic Cell Death Regulation Of Intracellular PH	Arachidonic Acid Secretion Long-chain Fatty Acid Transport Bone Mineralization Acid Secretion Fatty Acid Transport Negative Regulation Of Hormone Secretion Biomineral Tissue Development Neuropeptide Signaling Pathway Positive Regulation Of Hormone Secretion Monocarboxylic Acid Transport Osteoblast Differentiation Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Secretion By Cell Negative Regulation Of Secretion Cytosolic Calcium Ion Homeostasis Glucose Homeostasis Regulation Of Hormone Secretion Ossification Cellular Calcium Ion Homeostasis Lipid Transport Carboxylic Acid Transport Calcium Ion Homeostasis Organic Acid Transport Positive Regulation Of Secretion Lipid Localization Negative Regulation Of Transport Cellular Metal Ion Homeostasis Organic Anion Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis
Tagcloud ?		albeit bombesin chloroquine compensate cq dispensable dko evoked exclusively gastrin grp grpr histaminergic integrate interneurons intradermal itch knock ko lesser neuromedin nmbr nonhistaminergic nonoverlapping pruritogens releasing scratching superficial unexpected	albeit bombesin chloroquine compensate cq dispensable dko evoked exclusively gastrin grp grpr histaminergic integrate interneurons intradermal itch knock ko lesser neuromedin nonhistaminergic nonoverlapping pruritogens releasing scratching superficial unexpected
Tagcloud (Difference) ?
Tagcloud (Intersection) ?		albeit bombesin chloroquine compensate cq dispensable dko evoked exclusively gastrin grp grpr histaminergic integrate interneurons intradermal itch knock ko lesser neuromedin nmbr nonhistaminergic nonoverlapping pruritogens releasing scratching superficial unexpected