NMB and FBXL22

		NMB	FBXL22
Description		neuromedin B	F-box and leucine rich repeat protein 22
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Projection Neuron Projection	Nucleolus Cytoplasm Cytosol Z Disc
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding Neuromedin B Receptor Binding	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune System Process Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interferon-alpha Production Innate Immune Response Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Arachidonate Secretion Positive Regulation Of Osteoclast Proliferation Antiviral Innate Immune Response Sneeze Reflex Leydig Cell Proliferation Sensory Perception Of Itch Positive Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Testosterone Secretion	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Creatine kinase levels ( 29403010) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) P wave terminal force ( 28794112) Schizophrenia ( 29483656)	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Serum immune biomarker levels ( 32066700)
Interacting Genes		4 interacting genes: BIRC2 GADD45G NMBR TPP1	1 interacting genes: ACTN2
Entrez ID		4828	283807
HPRD ID		01210	16432
Ensembl ID		ENSG00000197696	ENSG00000197361
Uniprot IDs		P08949	A0A1W2PQW8 H0YMQ4 Q6P050
PDB IDs		1C98 1C9A 8H0P
Enriched GO Terms of Interacting Partners?			Titin Z Domain Binding Phospholipase C-activating Angiotensin-activated Signaling Pathway Actin Filament Uncapping Sensory Perception Of Itch Sneeze Reflex Positive Regulation Of Testosterone Secretion Neuromedin B Receptor Binding Positive Regulation Of Osteoclast Proliferation Leydig Cell Proliferation Microspike Assembly Positive Regulation Of Respiratory Gaseous Exchange Negative Regulation Of Transport FATZ Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity LIM Domain Binding Positive Regulation Of Endocytic Recycling Postsynaptic Actin Cytoskeleton Positive Regulation Of Actin Filament Depolymerization Negative Regulation Of Protein Localization To Cell Surface Titin Binding Postsynaptic Cytoskeleton Organization Angiotensin-activated Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Transport Regulation Of Endocytic Recycling Postsynaptic Density, Intracellular Component Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Protein Depolymerization Pseudopodium Reflex Arachidonate Secretion Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Cation Channel Activity Positive Regulation Of Interferon-alpha Production Focal Adhesion Assembly Negative Regulation Of Potassium Ion Transport Neuropeptide Hormone Activity Positive Regulation Of Potassium Ion Transport Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Protein Localization To Cell Surface Cell-substrate Junction Organization Positive Regulation Of Protein-containing Complex Disassembly Cell-substrate Junction Assembly Positive Regulation Of Transporter Activity Cardiac Muscle Cell Development Sarcomere Organization Structural Constituent Of Muscle Cardiac Cell Development Cell Projection
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