NMB and KIF23

		NMB	KIF23
Description		neuromedin B	kinesin family member 23
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Projection Neuron Projection	Nucleus Nucleoplasm Cytoplasm Mitochondrion Centrosome Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Focal Adhesion Midbody Mitotic Spindle Flemming Body Centralspindlin Complex
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding Neuromedin B Receptor Binding	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP Hydrolysis Activity
	Biological Process	Immune System Process Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interferon-alpha Production Innate Immune Response Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Arachidonate Secretion Positive Regulation Of Osteoclast Proliferation Antiviral Innate Immune Response Sneeze Reflex Leydig Cell Proliferation Sensory Perception Of Itch Positive Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Testosterone Secretion	Mitotic Spindle Elongation Mitotic Cytokinesis Microtubule-based Movement Positive Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Cell Division
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Mitotic Telophase/Cytokinesis Kinesins
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Creatine kinase levels ( 29403010) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) P wave terminal force ( 28794112) Schizophrenia ( 29483656)	Mean reticulocyte volume ( 32888494) Rheumatoid arthritis (ACPA-positive) ( 24532676)
Interacting Genes		4 interacting genes: BIRC2 GADD45G NMBR TPP1	12 interacting genes: ACTA1 ARF3 CLK1 LATS2 PLK1 PPP1CB RACGAP1 RBM34 SUMO2 USP8 YWHAB YWHAG
Entrez ID		4828	9493
HPRD ID		01210	05455
Ensembl ID		ENSG00000197696	ENSG00000137807
Uniprot IDs		P08949	A0A7I2V5Y5 Q02241
PDB IDs		1C98 1C9A 8H0P	3VHX
Enriched GO Terms of Interacting Partners?			Mitotic Cytokinesis Cytoskeleton-dependent Cytokinesis Regulation Of Protein Localization To Nucleus Spindle Midzone Midbody Cell Division Regulation Of Protein Localization Protein Sequestering Activity Neuromedin B Receptor Binding Protein Modification Process Myosin-light-chain-phosphatase Activity Negative Regulation Of Protein Localization To Nucleus Regulation Of Metabolic Process Extracellular Exosome Regulation Of Macromolecule Metabolic Process Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Sensory Perception Of Itch Sneeze Reflex Positive Regulation Of Testosterone Secretion Positive Regulation Of Osteoclast Proliferation Positive Regulation Of Respiratory Gaseous Exchange Leydig Cell Proliferation Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Synaptonemal Complex Disassembly Regulation Of Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Regulation Of Protein Stability Intracellular Signal Transduction Golgi Inheritance Myosin Phosphatase Activity Negative Regulation Of Protein Phosphorylation Negative Regulation Of Kinase Activity Protein Kinase C Inhibitor Activity Negative Regulation Of Protein Kinase Activity Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Centralspindlin Complex Actomyosin Contractile Ring Assembly
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