NMB and PTPRZ1

		NMB	PTPRZ1
Description		neuromedin B	protein tyrosine phosphatase receptor type Z1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Projection Neuron Projection	Extracellular Region Plasma Membrane Membrane Extracellular Matrix Synapse Perineuronal Net
	Molecular Function	Hormone Activity Neuropeptide Hormone Activity Protein Binding Neuromedin B Receptor Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding Hydrolase Activity
	Biological Process	Immune System Process Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interferon-alpha Production Innate Immune Response Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Arachidonate Secretion Positive Regulation Of Osteoclast Proliferation Antiviral Innate Immune Response Sneeze Reflex Leydig Cell Proliferation Sensory Perception Of Itch Positive Regulation Of Respiratory Gaseous Exchange Positive Regulation Of Testosterone Secretion	Hematopoietic Progenitor Cell Differentiation Protein Dephosphorylation Signal Transduction Axonogenesis Central Nervous System Development Learning Or Memory Neuron Projection Development Regulation Of Myelination Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Other interleukin signaling MDK and PTN in ALK signaling
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Creatine kinase levels ( 29403010) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) P wave terminal force ( 28794112) Schizophrenia ( 29483656)	Hand grip strength ( 27325353) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730)
Interacting Genes		4 interacting genes: BIRC2 GADD45G NMBR TPP1	13 interacting genes: ADD2 ALK ARHGAP35 CTNNB1 FYN GIT1 HMGB1 IL34 MDK MGAT5B PTN PTPRF TNR
Entrez ID		4828	5803
HPRD ID		01210	01481
Ensembl ID		ENSG00000197696	ENSG00000106278
Uniprot IDs		P08949	B4DFE7 P23471
PDB IDs		1C98 1C9A 8H0P	3JXF 3S97 5AWX 5H08 8FN8 8FN9
Enriched GO Terms of Interacting Partners?			Regulation Of Response To Wounding Cell Migration Regulation Of Oligodendrocyte Differentiation Regulation Of Neuron Projection Development Cell Motility Positive Regulation Of Neuron Projection Development Regulation Of Glial Cell Differentiation Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Developmental Process Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Component Organization Regulation Of Cell Projection Organization Leukocyte Migration Regulation Of Gliogenesis Schaffer Collateral - CA1 Synapse Positive Regulation Of Leukocyte Chemotaxis Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Development Learning Or Memory Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Glial Cell Differentiation Cell Development Nervous System Development Cognition Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Growth Factor Activity Heparin Binding Positive Regulation Of Blood Vessel Branching Learning Positive Regulation Of Cell Projection Organization Regulation Of Multicellular Organismal Development Regulation Of Neurogenesis Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway System Development Regulation Of Blood Vessel Branching Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Gliogenesis Positive Regulation Of Epithelial Cell Proliferation Response To Mechanical Stimulus Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Development
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