NMB and TPP1

Number of citations of the paper that reports this interaction (PMID 15158442)
3

Data Source:
HPRD (in vitro)

		NMB	TPP1
Gene Name		neuromedin B	tripeptidyl peptidase I
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Neuron Projection	Mitochondrion Lysosome Melanosome Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Hormone Activity Neuromedin B Receptor Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Tripeptidyl-peptidase Activity Peptide Binding Metal Ion Binding
	Biological Process	Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Glucose Homeostasis Positive Regulation Of Hormone Secretion Negative Regulation Of Hormone Secretion Arachidonic Acid Secretion	Proteolysis Lipid Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Lysosome Organization Nervous System Development Protein Catabolic Process Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Peptide Catabolic Process Cellular Protein Metabolic Process Bone Resorption Neuromuscular Process Controlling Balance
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: BIRC2 NMBR TPP1	6 interactors: CTC1 NMB OBFC1 POT1 TERT TINF2
Entrez ID		4828	1200
HPRD ID		01210	06415
Ensembl ID		ENSG00000197696	ENSG00000166340
Uniprot IDs		P08949	O14773
PDB IDs		1C98 1C9A	1R60 3EDY 3EE6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Negative Regulation Of Establishment Of Blood-brain Barrier Positive Regulation Of Single-stranded Telomeric DNA Binding Placenta Development Regulation Of Establishment Of Blood-brain Barrier Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Intermembrane Transport Bombesin Receptor Signaling Pathway Regulation Of Protein Monoubiquitination Vitamin E Metabolic Process Protection From Non-homologous End Joining At Telomere Telomere Capping Protein Localization To Chromosome, Telomeric Region Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity Telomere Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Telomere Maintenance Reproductive Structure Development Reproductive System Development Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Necroptotic Process Peptide Catabolic Process Negative Regulation Of Necrotic Cell Death Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Regulation Of Telomerase Activity Protein Catabolic Process Regulation Of Telomere Maintenance Intracellular PH Reduction Positive Regulation Of DNA Biosynthetic Process Regulation Of Necrotic Cell Death Developmental Process Involved In Reproduction PH Reduction Necroptotic Process Protein Localization To Chromosome Positive Regulation Of Protein Modification Process Bone Resorption Response To PH Positive Regulation Of DNA Binding Negative Regulation Of Cell Death Regulation Of Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Programmed Necrotic Cell Death Necrotic Cell Death Regulation Of Intracellular PH	Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Telomere Assembly Regulation Of DNA Replication Positive Regulation Of DNA Metabolic Process Homeostatic Process Telomere Formation Via Telomerase Positive Regulation Of DNA Replication Negative Regulation Of Telomere Maintenance Via Telomerase Chromosome Organization DNA Metabolic Process Negative Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Replicative Senescence Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Replication Cell Aging Negative Regulation Of Chromosome Organization Organelle Organization Negative Regulation Of DNA Metabolic Process Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of DNA Strand Elongation Negative Regulation Of Production Of SiRNA Involved In RNA Interference Positive Regulation Of Metabolic Process Negative Regulation Of RNA Interference Regulation Of Protein ADP-ribosylation Transcription, RNA-templated Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Negative Regulation Of Protein Glycosylation Regulation Of Chromosome Organization Nucleobase-containing Compound Metabolic Process Positive Regulation Of Helicase Activity Telomere Capping Protein Localization To Chromosome, Telomeric Region Positive Regulation Of Telomerase Activity Positive Regulation Of Telomere Maintenance Via Telomerase Bone Marrow Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process DNA Replication Cellular Nitrogen Compound Metabolic Process Replicative Cell Aging Negative Regulation Of Telomerase Activity Regulation Of Protein Glycosylation
Tagcloud ?		albeit bombesin chloroquine compensate cq dispensable dko evoked exclusively gastrin grp grpr histaminergic integrate interneurons intradermal itch knock ko lesser neuromedin nmbr nonhistaminergic nonoverlapping pruritogens releasing scratching superficial unexpected	0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum pot1 propodium ptop telomere telomeric tint1 trastuzumab trf2 trf2ip
Tagcloud (Difference) ?		albeit bombesin chloroquine compensate cq dispensable dko evoked exclusively gastrin grp grpr histaminergic integrate interneurons intradermal itch knock ko lesser neuromedin nmbr nonhistaminergic nonoverlapping pruritogens releasing scratching superficial unexpected	0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum pot1 propodium ptop telomere telomeric tint1 trastuzumab trf2 trf2ip
Tagcloud (Intersection) ?