LAMC1 and NID2

Number of citations: 0 (PubMedID 9733643)
Data Source: HPRD (in vitro)

		LAMC1	NID2
Name		laminin subunit gamma 1	nidogen 2
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Laminin-10 Complex Laminin-11 Complex Extracellular Exosome Protein Complex Involved In Cell-matrix Adhesion	Extracellular Region Basement Membrane Extracellular Space Plasma Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding
	Biological Process	Cell Adhesion Endoderm Development Tissue Development Cell Migration Extracellular Matrix Disassembly Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Maintenance Of Blood-brain Barrier Positive Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Muscle Cell Differentiation Protein-containing Complex Assembly Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway	Cell Adhesion Cell-matrix Adhesion Basement Membrane Organization
Pathways		Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells	Laminin interactions Laminin interactions
Drugs		Lanoteplase	None
GWAS		Apolipoprotein A1 levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Clozapine-induced agranulocytosis ( 25187353 ) Colorectal cancer ( 23266556 ) Colorectal cancer or advanced adenoma ( 30510241 ) Diastolic blood pressure ( 30224653 ) Fuchs's corneal dystrophy ( 28358029 ) HDL cholesterol levels ( 32203549 ) Height ( 31562340 ) Hemoglobin ( 32888494 ) Hypertriglyceridemia ( 27599772 ) LDL cholesterol levels in HIV infection ( 33109212 ) Red blood cell count ( 32888494 ) Systemic lupus erythematosus ( 24871463 )	Age-related hearing impairment ( 34108613 ) Apolipoprotein A1 levels ( 32203549 ) Body mass index ( 28892062 ) Craniofacial microsomia ( 26853712 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) HDL cholesterol levels ( 32203549 ) Hip index ( 34021172 ) Lung cancer (smoking interaction) ( 24658283 ) Pulmonary function ( 17903307 ) Triglyceride levels ( 32203549 29403010 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for body mass index ( 26785701 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )
Novel Interactors		None recorded	3 novel interactors: KCNJ1 POLE2 TNFRSF14
Interacting Genes		17 interacting genes: ANTXR2 APP ATF7IP CENPU FILNC1 KEAP1 LAMA5 NID1 NID2 SMARCA2 SNAPIN SNX2 SRPK1 TANK UBC WASHC3 WEE2-AS1	24 interacting genes: ANKRD13D CCN3 COL13A1 COL1A1 COL4A1 ELN GNE HOXC8 HSPG2 KPRP KRTAP1-3 KRTAP10-3 KRTAP6-2 LAMC1 LCE1A MAML3 PITX1 PLSCR4 RBP3 SKIL TFG UNKL ZNF581 ZNF774
Entrez ID		3915	22795
HPRD ID		01030	05654
Ensembl ID		ENSG00000135862	ENSG00000087303
Uniprot IDs		P11047 Q6NVY8	Q14112
PDB IDs		5XAU 7CEC 8DMK	Not available
GO Terms Enriched among Interactors		Extracellular Matrix Organization Extracellular Structure Organization Basement Membrane Extracellular Matrix Structural Constituent Insulin Receptor Binding	Extracellular Matrix Basement Membrane Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Matrix Structural Constituent Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Tissue Development Platelet-derived Growth Factor Binding Extracellular Matrix Constituent Conferring Elasticity Skeletal Muscle Tissue Development Collagen Trimer Collagen-activated Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Circulatory System Development