LAMC1

Name	laminin subunit gamma 1
Structure
Interactors	17 interactors: ANTXR2 APP ATF7IP CENPU FILNC1 KEAP1 LAMA5 NID1 NID2 SMARCA2 SNAPIN SNX2 SRPK1 TANK UBC WASHC3 WEE2-AS1
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Laminin-10 Complex Laminin-11 Complex Extracellular Exosome Protein Complex Involved In Cell-matrix Adhesion
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity
	Biological Process	Cell Adhesion Endoderm Development Tissue Development Cell Migration Extracellular Matrix Disassembly Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Maintenance Of Blood-brain Barrier Positive Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Muscle Cell Differentiation Protein-containing Complex Assembly Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways	Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells
Drugs	Lanoteplase
GWAS	Apolipoprotein A1 levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Clozapine-induced agranulocytosis ( 25187353 ) Colorectal cancer ( 23266556 ) Colorectal cancer or advanced adenoma ( 30510241 ) Diastolic blood pressure ( 30224653 ) Fuchs's corneal dystrophy ( 28358029 ) HDL cholesterol levels ( 32203549 ) Height ( 31562340 ) Hemoglobin ( 32888494 ) Hypertriglyceridemia ( 27599772 ) LDL cholesterol levels in HIV infection ( 33109212 ) Red blood cell count ( 32888494 ) Systemic lupus erythematosus ( 24871463 )
Entrez ID	3915
HPRD ID	01030
Ensembl ID	ENSG00000135862
Uniprot IDs	P11047 Q6NVY8
PDB IDs	5XAU 7CEC 8DMK
GO Terms Enriched among Interactors ?	Extracellular Matrix Organization Extracellular Structure Organization Basement Membrane Extracellular Matrix Structural Constituent Insulin Receptor Binding