LAMC1 and SNX2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		LAMC1	SNX2
Gene Name		laminin, gamma 1 (formerly LAMB2)	sorting nexin 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-1 Complex Extracellular Space Extracellular Matrix Laminin-10 Complex Laminin-11 Complex Extracellular Vesicular Exosome	Cytoplasm Endosome Membrane Membrane Extrinsic Component Of Membrane Lamellipodium Retromer Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Glycosphingolipid Binding	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Protein Complex Assembly Cell Adhesion Axon Guidance Endoderm Development Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Epithelial Cell Proliferation	Intracellular Protein Transport Endocytosis Vesicle Organization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Protein Oligomerization Lamellipodium Morphogenesis
Pathways		Axon guidance Laminin interactions ECM proteoglycans L1CAM interactions Non-integrin membrane-ECM interactions Degradation of the extracellular matrix	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Colorectal cancer ( 23266556)
Protein-Protein Interactions		13 interactors: ANTXR2 APP ATF7IP CCDC53 CENPU EIF3I LAMA5 NID1 NID2 SNAPIN SNX2 SRPK1 TANK	20 interactors: ACVR1B ACVR2B C1orf122 CSNK2B DUSP10 EGFR FNBP1 INSR LAMC1 LEPR MET NFYC PAK6 PDGFRA PDGFRB SNX1 SNX4 SNX5 SNX6 ZNF202
Entrez ID		3915	6643
HPRD ID		01030	09332
Ensembl ID		ENSG00000135862	ENSG00000205302
Uniprot IDs		P11047 Q6NVY8	B4DEK4 B7Z408 O60749
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Basement Membrane Organization Cell-matrix Adhesion Viral Process Cell-substrate Adhesion Axon Cargo Transport Positive Regulation Of Late Endosome To Lysosome Transport Synaptic Growth At Neuromuscular Junction Extracellular Matrix Disassembly Collateral Sprouting In Absence Of Injury Terminal Button Organization Autophagic Vacuole Maturation Cell Recognition Cellular Component Assembly Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Lamellipodium Morphogenesis Collateral Sprouting Axon Midline Choice Point Recognition Cell Projection Organization Nephron Development Regulation Of Protein Binding Cell Adhesion Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Synapse Organization Organelle Organization Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly DNA Packaging Endocytosis Negative Regulation Of Neuron Differentiation	Regulation Of Kinase Activity Protein Autophosphorylation Regulation Of Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Signal Transduction By Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Regulation Of Cell Migration Positive Regulation Of Locomotion Protein Phosphorylation Regulation Of Cell Motility Phosphorylation Regulation Of Signaling Retina Vasculature Development In Camera-type Eye Regulation Of Locomotion Regulation Of Cellular Component Movement Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Metanephric Glomerular Capillary Formation Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Tissue Development Positive Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Chemotaxis Positive Regulation Of DNA Metabolic Process Digestive System Development Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Glomerular Capillary Formation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Cellular Protein Metabolic Process Retrograde Transport, Endosome To Golgi Tube Morphogenesis Endosomal Transport Metanephric Glomerulus Vasculature Development Digestive Tract Morphogenesis
Tagcloud ?		5p adam10 brand clustered documented emerged erbb4 existed hdac7 helps igf1r intriguingly invasion meanwhile micrornas migration mir mirna mirnas overexpressed pax6 psen1 repressed simultaneously targets though tongue tscc utr	assembles assembling autonomously cation comprises conflicting endosomal endosomes heterodimer heterotrimer homodimer interchangeable mammalian mannose named nexin obligate performing retrieval retromer retromers snx1 sorting subcomplexes tgn truly vps26 vps29 vps35
Tagcloud (Difference) ?		5p adam10 brand clustered documented emerged erbb4 existed hdac7 helps igf1r intriguingly invasion meanwhile micrornas migration mir mirna mirnas overexpressed pax6 psen1 repressed simultaneously targets though tongue tscc utr	assembles assembling autonomously cation comprises conflicting endosomal endosomes heterodimer heterotrimer homodimer interchangeable mammalian mannose named nexin obligate performing retrieval retromer retromers snx1 sorting subcomplexes tgn truly vps26 vps29 vps35
Tagcloud (Intersection) ?