NFIC and GLRX

Number of citations of the paper that reports this interaction (PMID 9417094)
18

Data Source:
HPRD (in vivo, in vitro)

		NFIC	GLRX
Gene Name		nuclear factor I/C (CCAAT-binding transcription factor)	glutaredoxin (thioltransferase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Nucleus Mitochondrion Cytosol Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity	Electron Carrier Activity Glutathione Disulfide Oxidoreductase Activity Protein N-terminus Binding Glutathione Oxidoreductase Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Replication Transcription From RNA Polymerase II Promoter Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Transcription From RNA Polymerase II Promoter	Nucleobase-containing Small Molecule Interconversion Small Molecule Metabolic Process Cell Redox Homeostasis Positive Regulation Of Membrane Potential Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Protein Deglutathionylation Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		RNA Polymerase III Transcription RNA Polymerase III Transcription Termination RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation	Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS		Height ( 20881960)
Protein-Protein Interactions		10 interactors: CREBBP GLRX LLPH NFIB RFX1 TKTL2 TLX1 TPD52L3 ZCCHC14 ZKSCAN7	7 interactors: AQP5 CASP3 GOT2 MAP3K5 MMP23B NFIC PTPN1
Entrez ID		4782	2745
HPRD ID		09009	02707
Ensembl ID		ENSG00000141905	ENSG00000173221
Uniprot IDs		B7Z4T6 P08651	P35754
PDB IDs			1B4Q 1JHB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Protein Deglutathionylation Lung Ciliated Cell Differentiation Principal Sensory Nucleus Of Trigeminal Nerve Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development N-terminal Peptidyl-lysine Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Germ-line Stem Cell Maintenance Negative Regulation Of Mesenchymal Cell Proliferation Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Type II Pneumocyte Differentiation Clara Cell Differentiation Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Anterior Commissure Morphogenesis RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process N-terminal Protein Amino Acid Acetylation Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Nucleobase-containing Compound Metabolic Process Lung Secretory Cell Differentiation Commissural Neuron Axon Guidance Positive Regulation Of Sodium Ion Transmembrane Transport Nucleobase-containing Small Molecule Interconversion Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Type I Pneumocyte Differentiation Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Gene Expression N-terminal Protein Amino Acid Modification RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Cellular Response To Heat Nitrogen Compound Metabolic Process Negative Regulation Of Stem Cell Proliferation Gene Expression Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Central Nervous System Projection Neuron Axonogenesis Cellular Macromolecule Biosynthetic Process	Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Neuron Death Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Positive Regulation Of Endopeptidase Activity Odontogenesis Positive Regulation Of Peptidase Activity Fumarate Metabolic Process Regulation Of Protein Kinase Activity Aspartate Catabolic Process 4-hydroxyproline Catabolic Process Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Intrinsic Apoptotic Signaling Pathway L-kynurenine Metabolic Process Platelet-derived Growth Factor Receptor-beta Signaling Pathway Carbon Dioxide Transport Cellular Response To Oxidative Stress Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Kinase Activity Glutamate Catabolic Process Pancreatic Juice Secretion Glial Cell Apoptotic Process Negative Regulation Of Kinase Activity Protein Processing Regulation Of Apoptotic DNA Fragmentation Aspartate Metabolic Process Saliva Secretion Regulation Of Protein Phosphorylation Regulation Of Neuron Death Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Glycerol Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Phosphorylation Negative Regulation Of Activated T Cell Proliferation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Kynurenine Metabolic Process Dicarboxylic Acid Catabolic Process Polyol Transport Cellular Water Homeostasis Apoptotic Signaling Pathway
Tagcloud ?		advance avian bcl2 bcl2l1 ccaat cebpb construction coordinated cytoscape datasets differentially downloaded encyclopedia enrichment genomes gse14359 homolog il6 interpret kyoto omnibus ontology osteosarcoma pivotal rara rel rela reticuloendotheliosis tp53	affymetrix agtr1 benjamini cdkn1c crh cytotrophoblast dscr1 gatm gnas hochberg hpgd imprinted indo inhba intrauterine iugr lep maternally meg3 mest paternally phlda2 placentae plagl1 psg slc solute u133a villous
Tagcloud (Difference) ?		advance avian bcl2 bcl2l1 ccaat cebpb construction coordinated cytoscape datasets differentially downloaded encyclopedia enrichment genomes gse14359 homolog il6 interpret kyoto omnibus ontology osteosarcoma pivotal rara rel rela reticuloendotheliosis tp53	affymetrix agtr1 benjamini cdkn1c crh cytotrophoblast dscr1 gatm gnas hochberg hpgd imprinted indo inhba intrauterine iugr lep maternally meg3 mest paternally phlda2 placentae plagl1 psg slc solute u133a villous
Tagcloud (Intersection) ?