NFIC and TBR1

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (pull down)

		NFIC	TBR1
Description		nuclear factor I C	T-box brain transcription factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Chromatin DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Odontogenesis Of Dentin-containing Tooth Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Conditioned Taste Aversion Cell Fate Specification Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Specification Of Animal Organ Identity Gene Expression Regulation Of Gene Expression Regulation Of Neuron Projection Development Amygdala Development Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Cerebral Cortex Development Neuron Differentiation Hindbrain Development Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Axon Guidance
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Alzheimer's disease (APOE e4 interaction) ( 28183528) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Automobile speeding propensity ( 30643258) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 20881960 31562340 28552196 25282103) High light scatter reticulocyte count ( 32888494) Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Monocyte count ( 32888494) Nevus count or cutaneous melanoma ( 30429480) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum urate levels in chronic kidney disease ( 30181573) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Educational attainment ( 25201988) Intelligence (MTAG) ( 29326435) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tourette syndrome ( 30818990)
Interacting Genes		54 interacting genes: CBLC CREBBP ELK3 EPHA2 ERG ETV7 FBXO7 FOS FOXL1 GATA2 GATA3 GLIS1 GLIS2 GLRX KLF16 KLF8 LATS2 LHX2 LHX3 LHX4 LLPH MAP2K3 MAPK14 MYC NFIB NSD3 PAX2 PAX6 PAX7 PAX8 PRDM1 RFX1 SFN SOX10 SOX15 SOX17 SOX2 SOX3 SOX5 SOX6 SOX9 SP7 TBR1 TBXT TEAD2 TKTL2 TLX1 TLX2 TLX3 TPD52L3 UBC YY1 ZCCHC14 ZKSCAN7	7 interacting genes: CASK FOXP2 HNF1B HOXA1 MYCBP2 NFIC NFIX
Entrez ID		4782	10716
HPRD ID		09009	07055
Ensembl ID		ENSG00000141905	ENSG00000136535
Uniprot IDs		B7Z4T6 P08651	Q16650
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Animal Organ Development Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Neuron Differentiation Nucleus Sequence-specific DNA Binding Cell Fate Specification Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process Positive Regulation Of Metabolic Process Cell Fate Commitment Regulation Of Cell Differentiation Anatomical Structure Morphogenesis Negative Regulation Of Developmental Process Regulation Of MiRNA Transcription Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Tube Formation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Artery Development Anatomical Structure Morphogenesis Regulation Of Transcription By RNA Polymerase II Genitalia Development Macromolecule Biosynthetic Process Transcription Coregulator Binding Gene Expression Nervous System Process Tube Morphogenesis Semicircular Canal Formation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Artery Morphogenesis Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Putamen Development Caudate Nucleus Development Positive Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Abducens Nerve Formation Optokinetic Behavior Folate Import Across Plasma Membrane Positive Regulation Of Oligodendrocyte Progenitor Proliferation Hepatoblast Differentiation Regulation Of Pronephros Size Blood Vessel Morphogenesis DNA Binding Neuromuscular Process Regulation Of RNA Metabolic Process Folate Transmembrane Transport
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