NFIC and PAX7

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (proximity labelling technology, pull down)

		NFIC	PAX7
Description		nuclear factor I C	paired box 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Odontogenesis Of Dentin-containing Tooth Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Muscle Organ Development Skeletal Muscle Tissue Development Anatomical Structure Morphogenesis Regulation Of Cell Fate Commitment Regulation Of Gene Expression Skeletal Muscle Satellite Cell Commitment Skeletal Muscle Satellite Cell Differentiation Spinal Cord Association Neuron Differentiation Dorsal/ventral Neural Tube Patterning Negative Regulation Of Apoptotic Process Skeletal Muscle Tissue Regeneration Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Embryonic Skeletal System Development Cartilage Development Muscle Tissue Morphogenesis Regulation Of Chromatin Organization Positive Regulation Of Myoblast Proliferation
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation	Specification of the neural plate border
Drugs
Diseases			Alveolar rhabdomyosarcoma
GWAS		Alzheimer's disease (APOE e4 interaction) ( 28183528) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Automobile speeding propensity ( 30643258) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 20881960 31562340 28552196 25282103) High light scatter reticulocyte count ( 32888494) Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Monocyte count ( 32888494) Nevus count or cutaneous melanoma ( 30429480) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum urate levels in chronic kidney disease ( 30181573) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)	Body mass index ( 23669352) Cortical surface area (visual PC2) ( 32198502) Knee osteoarthritis ( 28916551) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 33898419) Orofacial cleft x maternal periconceptional alcohol use interaction (2df) ( 33937227) Orofacial cleft x maternal periconceptional multivitamin use interaction (2df) ( 33937227) Orofacial cleft x maternal periconceptional smoking interaction (2df) ( 33937227) Orofacial clefts ( 22863734) Percentage gas trapping ( 26030696) Response to amphetamines ( 22952603) Urate levels in lean individuals ( 25811787)
Interacting Genes		54 interacting genes: CBLC CREBBP ELK3 EPHA2 ERG ETV7 FBXO7 FOS FOXL1 GATA2 GATA3 GLIS1 GLIS2 GLRX KLF16 KLF8 LATS2 LHX2 LHX3 LHX4 LLPH MAP2K3 MAPK14 MYC NFIB NSD3 PAX2 PAX6 PAX7 PAX8 PRDM1 RFX1 SFN SOX10 SOX15 SOX17 SOX2 SOX3 SOX5 SOX6 SOX9 SP7 TBR1 TBXT TEAD2 TKTL2 TLX1 TLX2 TLX3 TPD52L3 UBC YY1 ZCCHC14 ZKSCAN7	14 interacting genes: AIRIM CIB1 CSNK2A1 CT55 FHL1 HIRA HNF1B HOMER3 KRTAP19-7 MAGOHB NEDD4 NFIC NFIX TCAP
Entrez ID		4782	5081
HPRD ID		09009	01331
Ensembl ID		ENSG00000141905	ENSG00000009709
Uniprot IDs		B7Z4T6 P08651	P23759
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Animal Organ Development Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Neuron Differentiation Nucleus Sequence-specific DNA Binding Cell Fate Specification Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process Positive Regulation Of Metabolic Process Cell Fate Commitment Regulation Of Cell Differentiation Anatomical Structure Morphogenesis Negative Regulation Of Developmental Process Regulation Of MiRNA Transcription Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	Transmembrane Transporter Binding Negative Regulation Of Macromolecule Biosynthetic Process Protein Targeting Negative Regulation Of Metabolic Process RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Targeting To Vacuole Nucleic Acid Metabolic Process Animal Organ Morphogenesis DNA-templated Transcription Formation Of Structure Involved In A Symbiotic Process Epithelial Tube Formation Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development HIR Complex Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Male Germ Cell Proliferation Anatomical Structure Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Protein Localization To Vacuole Regulation Of Growth Regulation Of Potassium Ion Transmembrane Transport Channel Inhibitor Activity Chromatin Hepatoblast Differentiation Regulation Of Pronephros Size Titin-telethonin Complex Titin Z Domain Binding Sarcomerogenesis Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Potassium Ion Transport Phosphothreonine Residue Binding Transcription By RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Skeletal Muscle Myosin Thick Filament Assembly G Protein-coupled Glutamate Receptor Binding Endomitotic Cell Cycle Calcium-dependent Protein Kinase Inhibitor Activity Exon-exon Junction Subcomplex Mago-y14 Zinc Ion Import Into Golgi Lumen Protein Localization To Vacuole
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