NFIC and SOX17

Number of citations: 106 (PubMedID 35140242)
Data Source: BioGRID (pull down)

		NFIC	SOX17
Name		nuclear factor I C	SRY-box transcription factor 17
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Odontogenesis Of Dentin-containing Tooth Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Angiogenesis Vasculogenesis Metanephros Development Endoderm Formation Endodermal Cell Fate Specification Inner Cell Mass Cellular Morphogenesis Heart Looping Cardiogenic Plate Morphogenesis Embryonic Heart Tube Morphogenesis Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Spermatogenesis Gastrulation Endoderm Development Endodermal Cell Fate Determination Heart Development Tissue Development Gene Expression Positive Regulation Of Gene Expression Wnt Signaling Pathway Rostrocaudal Neural Tube Patterning Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Protein Destabilization Embryonic Heart Tube Development Endodermal Cell Differentiation Cell Migration Involved In Gastrulation Response To Alkaloid Regulation Of Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Embryonic Organ Development Embryonic Foregut Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Stem Cell Differentiation Stem Cell Fate Specification Protein Stabilization Endocardium Formation Cardiac Cell Fate Determination Heart Formation Endocardial Cell Differentiation Common Bile Duct Development Gallbladder Development Endodermal Digestive Tract Morphogenesis Regulation Of Stem Cell Proliferation Ureter Development Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Endodermal Cell Differentiation Cellular Response To Leukemia Inhibitory Factor Regulation Of Stem Cell Division Regulation Of Cardiac Cell Fate Specification Positive Regulation Of Stem Cell Differentiation
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation	Deactivation of the beta-catenin transactivating complex Formation of definitive endoderm Specification of primordial germ cells Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Diseases		None	Vesicoureteral reflux
GWAS		Alzheimer's disease (APOE e4 interaction) ( 28183528 ) Apolipoprotein A1 levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Automobile speeding propensity ( 30643258 ) HDL cholesterol ( 30275531 ) HDL cholesterol levels ( 32203549 ) Heel bone mineral density ( 30598549 ) Height ( 20881960 31562340 28552196 25282103 ) High light scatter reticulocyte count ( 32888494 ) Hip circumference ( 28552196 ) Hip circumference adjusted for BMI ( 28552196 ) Monocyte count ( 32888494 ) Nevus count or cutaneous melanoma ( 30429480 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Serum urate levels in chronic kidney disease ( 30181573 ) Weight ( 28552196 ) Youthful appearance (self-reported) ( 32339537 )	Apolipoprotein B levels ( 32203549 ) Cholesterol, total ( 24097068 ) Factor VIII levels ( 30586737 ) Intracranial aneurysm ( 20364137 33199917 18997786 ) LDL cholesterol ( 24097068 ) LDL cholesterol levels ( 28334899 30698716 32203549 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels in HIV infection ( 33109212 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Pulmonary arterial hypertension ( 30527956 ) Total cholesterol levels ( 28334899 )
Novel Interactors		1 novel interactors: ERGIC1	1 novel interactors: PKD1
Interacting Genes		54 interacting genes: CBLC CREBBP ELK3 EPHA2 ERG ETV7 FBXO7 FOS FOXL1 GATA2 GATA3 GLIS1 GLIS2 GLRX KLF16 KLF8 LATS2 LHX2 LHX3 LHX4 LLPH MAP2K3 MAPK14 MYC NFIB NSD3 PAX2 PAX6 PAX7 PAX8 PRDM1 RFX1 SFN SOX10 SOX15 SOX17 SOX2 SOX3 SOX5 SOX6 SOX9 SP7 TBR1 TBXT TEAD2 TKTL2 TLX1 TLX2 TLX3 TPD52L3 UBC YY1 ZCCHC14 ZKSCAN7	4 interacting genes: CTNNB1 HNF1B NFIC NFIX
Entrez ID		4782	64321
HPRD ID		09009	18085
Ensembl ID		ENSG00000141905	ENSG00000164736
Uniprot IDs		B7Z4T6 P08651	Q9H6I2
PDB IDs		Not available	2YUL 4A3N
GO Terms Enriched among Interactors		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Animal Organ Development Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Neuron Differentiation Nucleus Sequence-specific DNA Binding Cell Fate Specification Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process Positive Regulation Of Metabolic Process Cell Fate Commitment Regulation Of Cell Differentiation Anatomical Structure Morphogenesis Negative Regulation Of Developmental Process Regulation Of MiRNA Transcription Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	Genitalia Development Nephric Duct Development Mesonephric Duct Development Positive Regulation Of Transcription By RNA Polymerase II Nephron Tubule Formation Epithelial Tube Morphogenesis Animal Organ Morphogenesis Branching Morphogenesis Of An Epithelial Tube Nephron Tubule Morphogenesis Positive Regulation Of RNA Biosynthetic Process Kidney Morphogenesis Kidney Development Morphogenesis Of A Branching Structure Morphogenesis Of A Branching Epithelium Positive Regulation Of DNA-templated Transcription Renal Tubule Morphogenesis Hindbrain Development Positive Regulation Of RNA Metabolic Process Reproductive Structure Development Nephron Tubule Development Embryonic Epithelial Tube Formation Tube Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Renal Tubule Development Pancreas Development Epithelium Development Epithelial Tube Formation Gland Development Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Tube Morphogenesis Regulation Of Transcription By RNA Polymerase II Transcription Coregulator Binding Detection Of Mechanical Stimulus Morphogenesis Of An Epithelium Positive Regulation Of Macromolecule Biosynthetic Process Mesonephric Tubule Development Mesonephric Epithelium Development Skin Development Positive Regulation Of Biosynthetic Process Tissue Morphogenesis DNA-templated Transcription Lateral Plasma Membrane Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Odontogenesis Of Dentin-containing Tooth Kidney Epithelium Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process