NFIC and TBXT

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (pull down)

		NFIC	TBXT
Description		nuclear factor I C	T-box transcription factor T
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Odontogenesis Of Dentin-containing Tooth Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Mesoderm Formation Cell Fate Specification Somitogenesis Heart Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Signal Transduction Mesoderm Development Anterior/posterior Axis Specification, Embryo Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Cell Myoblast Differentiation Primitive Streak Formation
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation	Cardiogenesis Germ layer formation at gastrulation Epithelial-Mesenchymal Transition (EMT) during gastrulation Formation of paraxial mesoderm Formation of axial mesoderm Formation of definitive endoderm
Drugs
Diseases
GWAS		Alzheimer's disease (APOE e4 interaction) ( 28183528) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Automobile speeding propensity ( 30643258) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 20881960 31562340 28552196 25282103) High light scatter reticulocyte count ( 32888494) Hip circumference ( 28552196) Hip circumference adjusted for BMI ( 28552196) Monocyte count ( 32888494) Nevus count or cutaneous melanoma ( 30429480) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum urate levels in chronic kidney disease ( 30181573) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		54 interacting genes: CBLC CREBBP ELK3 EPHA2 ERG ETV7 FBXO7 FOS FOXL1 GATA2 GATA3 GLIS1 GLIS2 GLRX KLF16 KLF8 LATS2 LHX2 LHX3 LHX4 LLPH MAP2K3 MAPK14 MYC NFIB NSD3 PAX2 PAX6 PAX7 PAX8 PRDM1 RFX1 SFN SOX10 SOX15 SOX17 SOX2 SOX3 SOX5 SOX6 SOX9 SP7 TBR1 TBXT TEAD2 TKTL2 TLX1 TLX2 TLX3 TPD52L3 UBC YY1 ZCCHC14 ZKSCAN7	3 interacting genes: NFIA NFIB NFIC
Entrez ID		4782	6862
HPRD ID		09009	03236
Ensembl ID		ENSG00000141905	ENSG00000164458
Uniprot IDs		B7Z4T6 P08651	J3KP65 O15178
PDB IDs			5QRF 5QRG 5QRH 5QRI 5QRJ 5QRK 5QRL 5QRM 5QRN 5QRO 5QRP 5QRQ 5QRR 5QRS 5QRT 5QRU 5QRV 5QRW 5QRX 5QRY 5QRZ 5QS0 5QS1 5QS2 5QS3 5QS4 5QS5 5QS6 5QS7 5QS8 5QS9 5QSA 5QSB 5QSC 5QSD 5QSE 5QSF 5QSG 5QSH 5QSI 5QSJ 5QSK 5QSL 5QT0 6F58 6F59 6ZU8 7HI8 7HI9 7ZK2 7ZKF 7ZL2 8A10 8A7N 8CDN 8FMU
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Animal Organ Development Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Neuron Differentiation Nucleus Sequence-specific DNA Binding Cell Fate Specification Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Developmental Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process Positive Regulation Of Metabolic Process Cell Fate Commitment Regulation Of Cell Differentiation Anatomical Structure Morphogenesis Negative Regulation Of Developmental Process Regulation Of MiRNA Transcription Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process	Glial Cell Fate Specification DNA Replication Exit From Mitosis Generation Of Neurons Neuron Fate Specification Glial Cell Proliferation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Retina Development In Camera-type Eye Cell Fate Specification DNA-binding Transcription Factor Activity Neural Precursor Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Lung Ciliated Cell Differentiation Neurogenesis DNA Metabolic Process Double-stranded DNA Binding Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Cell Differentiation Involved In Salivary Gland Development Fibrillar Center Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Brain Renin-angiotensin System Positive Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Principal Sensory Nucleus Of Trigeminal Nerve Development Developmental Maturation Chromatin Response To Wounding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Club Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Salivary Gland Cavitation Anterior Commissure Morphogenesis Ribosomal Protein S6 Kinase Activity Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Transcription By RNA Polymerase II Ureter Development Positive Regulation Of Metabolic Process Gene Expression Multi-ciliated Epithelial Cell Differentiation Type II Pneumocyte Differentiation Cerebellar Mossy Fiber Negative Regulation Of Mesenchymal Cell Proliferation Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Animal Organ Development Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Type I Pneumocyte Differentiation Negative Regulation Of Meiotic Nuclear Division Macromolecule Biosynthetic Process
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