NHLH1 and PSME2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NHLH1	PSME2
Gene Name		nescient helix loop helix 1	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Proteasome Complex Nucleoplasm Cytosol Proteasome Activator Complex Membrane Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Dimerization Activity
	Biological Process	Transcription, DNA-templated Central Nervous System Development Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CENPP CSRP3 HIVEP1 INO80E LMO1 LMO2 LMO4 PIM1 PSME2 TCF3	6 interactors: APP EPHA2 MYOD1 NAA10 NHLH1 PSME1
Entrez ID		4807	5721
HPRD ID		01212	03697
Ensembl ID		ENSG00000171786	ENSG00000100911
Uniprot IDs		Q02575 Q5T203	Q86SZ7 Q9UL46
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Mitotic Cell Cycle Gene Expression Detection Of Muscle Stretch Positive Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Transcription, DNA-templated Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition RNA Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Axial Mesoderm Morphogenesis Immune System Development Immunoglobulin V(D)J Recombination Mitotic Cell Cycle Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Muscle Stretch Regulation Of Mitotic Cell Cycle Phase Transition Axial Mesoderm Development Regulation Of Cell Cycle Phase Transition DNA Recombination Negative Regulation Of Erythrocyte Differentiation B Cell Lineage Commitment Cellular Response To Thyroid Hormone Stimulus Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition MRNA Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle RNA Metabolic Process Spinal Cord Association Neuron Differentiation MRNA Transcription Peyer's Patch Development Response To Thyroid Hormone	Cellular Protein Modification Process Notochord Cell Development Positive Regulation Of Metabolic Process Internal Protein Amino Acid Acetylation Protein Acetylation Myoblast Fate Determination Myotube Differentiation Involved In Skeletal Muscle Regeneration Skeletal Muscle Fiber Adaptation Synaptic Growth At Neuromuscular Junction N-terminal Peptidyl-glutamic Acid Acetylation N-terminal Peptidyl-serine Acetylation Positive Regulation Of Peptidase Activity Collateral Sprouting In Absence Of Injury Axial Mesoderm Formation Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Collateral Sprouting Axon Midline Choice Point Recognition Notochord Formation Apoptotic Process Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Lens Fiber Cell Morphogenesis Axial Mesoderm Morphogenesis Positive Regulation Of Skeletal Muscle Tissue Regeneration Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Hydrolase Activity Cell Death Death Axon Choice Point Recognition Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Cellular Metabolic Process Myoblast Fate Commitment Developmental Growth Positive Regulation Of Cell Cycle Regulation Of Developmental Growth Positive Regulation Of Proteolysis Neuron Remodeling Axial Mesoderm Development Skeletal Muscle Adaptation N-terminal Protein Amino Acid Acetylation Notochord Morphogenesis Positive Regulation Of Transcription, DNA-templated Protein Phosphorylation Protein Metabolic Process Activation Of Rac GTPase Activity Regulation Of Endopeptidase Activity
Tagcloud ?		basic bhlh clone coding complementary consists daltons developing dronhlh droscl drosophila embryos encodes helix homology identical instar kilobase library mammalian melanogaster nervous nhlh2 northern pupal restricted reveals subset transcript	16th 2d3 autoimmunity chemotaxis dige dihydroxyvitamin entitled epi extreme functionality hereby homing hspa8 immunomodulatory isoelectrical lacks maldi mw picking picture prolong proteomics reinforcing spots synchronized tof tx527 workshop yne
Tagcloud (Difference) ?		basic bhlh clone coding complementary consists daltons developing dronhlh droscl drosophila embryos encodes helix homology identical instar kilobase library mammalian melanogaster nervous nhlh2 northern pupal restricted reveals subset transcript	16th 2d3 autoimmunity chemotaxis dige dihydroxyvitamin entitled epi extreme functionality hereby homing hspa8 immunomodulatory isoelectrical lacks maldi mw picking picture prolong proteomics reinforcing spots synchronized tof tx527 workshop yne
Tagcloud (Intersection) ?