NHLH1 and CSRP3

Number of citations: 0 (PubMedID 12878195)
Data Source: HPRD (two hybrid, in vitro)

		NHLH1	CSRP3
Name		nescient helix-loop-helix 1	cysteine and glycine rich protein 3
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Sarcomere Z Disc
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Actin Binding Protein Binding Structural Constituent Of Muscle Telethonin Binding Identical Protein Binding Actinin Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of The Force Of Heart Contraction Cardiac Muscle Hypertrophy Intracellular Calcium Ion Homeostasis Inflammatory Response Heart Development Muscle Organ Development Skeletal Muscle Tissue Development Insulin Receptor Signaling Pathway Cell Differentiation T-tubule Organization Protein Localization To Organelle Detection Of Muscle Stretch Glucose Homeostasis Sarcomere Organization Negative Regulation Of Myoblast Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Cardiac Muscle Tissue Development Cardiac Myofibril Assembly Cardiac Muscle Contraction Muscle Tissue Development Establishment Of Protein Localization To Organelle Phospholipase C/protein Kinase C Signal Transduction Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Actin Filament Severing Positive Regulation Of Actin Filament Severing
Diseases		None	Hypertrophic cardiomyopathy (HCM)
GWAS		No GWAS studies recorded	Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Mosquito bite size ( 28199695 ) Red blood cell count ( 27863252 32888494 )
Interacting Genes		12 interacting genes: CCT7 CENPP CSRP3 INO80E LMO1 LMO2 LMO4 NFIA NFIB PIM1 PSME2 TCF3	11 interacting genes: ACTN1 FHL1 HDAC4 LDHD LIMS1 MYF6 MYOD1 MYOG NHLH1 RIN3 SPTB
Entrez ID		4807	8048
HPRD ID		01212	07525
Ensembl ID		ENSG00000171786	ENSG00000129170
Uniprot IDs		Q02575 Q5T203	A0A3B3ISZ2 A2TDB8 P50461
PDB IDs		Not available	2O10 2O13
GO Terms Enriched among Interactors		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Neuron Fate Specification Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Glial Cell Fate Specification Nucleoplasm Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Exit From Mitosis Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Generation Of Neurons Regulation Of Macromolecule Biosynthetic Process BHLH Transcription Factor Binding Glial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Lung Ciliated Cell Differentiation Positive Regulation Of Cardioblast Proliferation Positive Regulation Of Actin Filament Severing Regulation Of Gene Expression Positive Regulation Of Telomere Maintenance Retina Development In Camera-type Eye DNA Metabolic Process Cell Differentiation Involved In Salivary Gland Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Negative Regulation Of Actin Filament Severing Nucleus Regulation Of Multicellular Organismal Process Regulation Of Stem Cell Proliferation Regulation Of T Cell Homeostatic Proliferation Neural Precursor Cell Proliferation Principal Sensory Nucleus Of Trigeminal Nerve Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Proteasome Activator Complex Vitamin D Response Element Binding Ventral Spinal Cord Interneuron Differentiation Positive Regulation Of Chromosome Organization	Regulation Of Myotube Differentiation Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Skeletal Muscle Fiber Development Muscle Cell Fate Commitment Positive Regulation Of Striated Muscle Tissue Development Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Development DNA-binding Transcription Activator Activity Regulation Of Skeletal Muscle Tissue Development Muscle Organ Development Muscle Structure Development Regulation Of Muscle Cell Differentiation Regulation Of Striated Muscle Tissue Development Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Muscle Organ Development Positive Regulation Of Myoblast Differentiation Protein Dimerization Activity E-box Binding Skeletal Muscle Cell Differentiation Response To Denervation Involved In Regulation Of Muscle Adaptation Skeletal Muscle Tissue Development Response To Muscle Inactivity Cell Differentiation Regulation Of Myoblast Differentiation Positive Regulation Of Muscle Cell Differentiation Response To Inactivity Muscle Cell Development Cellular Developmental Process Striated Muscle Tissue Development Skeletal Muscle Tissue Regeneration Regulation Of Myoblast Fusion Myotube Differentiation Muscle Tissue Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Skeletal Muscle Fiber Development Cell Fate Commitment Myotube Cell Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Estradiol Stimulus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Sequence-specific Double-stranded DNA Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Tissue Regeneration Cortical Actin Cytoskeleton Negative Regulation Of Mast Cell Chemotaxis D-lactate Dehydrogenase (cytochrome) Activity