NHLH1 and LMO1

Number of citations of the paper that reports this interaction (PMID 10603358)
5

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		NHLH1	LMO1
Gene Name		nescient helix loop helix 1	LIM domain only 1 (rhombotin 1)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Dimerization Activity	Zinc Ion Binding
	Biological Process	Transcription, DNA-templated Central Nervous System Development Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS			Alcohol consumption ( 23743675) Fasting glucose-related traits (interaction with BMI) ( 22581228) Neuroblastoma ( 22941191 21124317)
Protein-Protein Interactions		10 interactors: CENPP CSRP3 HIVEP1 INO80E LMO1 LMO2 LMO4 PIM1 PSME2 TCF3	38 interactors: ADAMTSL4 AES BCL11A BLZF1 CARD9 CDCA7L CDX4 CEP170P1 CEP44 ERBB2IP FAM154A FAM208B GABPB1 GATA3 GOLGA2 IKZF3 KANK2 KRT40 LDB1 LPXN LYL1 LZTS2 NHLH1 NUTM1 PHC2 PTPN3 RBBP8 REL SNTA1 SOX5 SPERT TAL1 TAL2 TCF4 TFIP11 TRIM27 ZBTB43 ZNF219
Entrez ID		4807	4004
HPRD ID		01212	01738
Ensembl ID		ENSG00000171786	ENSG00000166407
Uniprot IDs		Q02575 Q5T203	P25800
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Mitotic Cell Cycle Gene Expression Detection Of Muscle Stretch Positive Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Transcription, DNA-templated Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition RNA Biosynthetic Process G1/S Transition Of Mitotic Cell Cycle Nitrogen Compound Metabolic Process Axial Mesoderm Morphogenesis Immune System Development Immunoglobulin V(D)J Recombination Mitotic Cell Cycle Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Muscle Stretch Regulation Of Mitotic Cell Cycle Phase Transition Axial Mesoderm Development Regulation Of Cell Cycle Phase Transition DNA Recombination Negative Regulation Of Erythrocyte Differentiation B Cell Lineage Commitment Cellular Response To Thyroid Hormone Stimulus Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition MRNA Transcription From RNA Polymerase II Promoter Regulation Of Cell Cycle RNA Metabolic Process Spinal Cord Association Neuron Differentiation MRNA Transcription Peyer's Patch Development Response To Thyroid Hormone	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Wnt Signaling Pathway Organ Development Positive Regulation Of Cellular Metabolic Process Interferon-gamma Secretion Multicellular Organismal Development Cellular Metabolic Process Anatomical Structure Development Developmental Process System Development Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Regulation Of Binding Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cytokine Biosynthetic Process Definitive Hemopoiesis Embryo Development
Tagcloud ?		basic bhlh clone coding complementary consists daltons developing dronhlh droscl drosophila embryos encodes helix homology identical instar kilobase library mammalian melanogaster nervous nhlh2 northern pupal restricted reveals subset transcript	bhlh collaborates collaboration construct demonstrating dispensable dysregulation elements exerts helix inappropriately interfere interstitial juxtaposed lastly lymphoblastic mesoderm misexpressed oncogenesis product recapitulating scl sil situation supporting tcl5 transactivation translocations whereby
Tagcloud (Difference) ?		basic clone coding complementary consists daltons developing dronhlh droscl drosophila embryos encodes homology identical instar kilobase library mammalian melanogaster nervous nhlh2 northern pupal restricted reveals subset transcript	collaborates collaboration construct demonstrating dispensable dysregulation elements exerts inappropriately interfere interstitial juxtaposed lastly lymphoblastic mesoderm misexpressed oncogenesis product recapitulating scl sil situation supporting tcl5 transactivation translocations whereby
Tagcloud (Intersection) ?		bhlh helix