NHLH1 and LMO1

Number of citations of the paper that reports this interaction (PubMedID 10603358)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		NHLH1	LMO1
Description		nescient helix-loop-helix 1	LIM domain only 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Transcription Coactivator Activity Protein Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation
Pathways			RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases
GWAS			Alcohol consumption ( 23743675) Body mass index ( 31888951 26426971 28892062) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Diastolic blood pressure ( 27618447) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Height ( 31562340) Malaria ( 31844061) Neuroblastoma ( 22941191 21124317) Offspring birth weight ( 31043758) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Restless legs syndrome ( 33239738) Sporadic neuroblastoma ( 28545128) Systolic blood pressure ( 27618447)
Interacting Genes		12 interacting genes: CCT7 CENPP CSRP3 INO80E LMO1 LMO2 LMO4 NFIA NFIB PIM1 PSME2 TCF3	122 interacting genes: ABI1 ABI2 ADAMTSL4 AKAP9 AKNA ASB15 BANP BCAS2 BCL11A BIVM BLZF1 BNC2 BYSL CARD9 CBY2 CCDC33 CCDC88B CDCA7L CDX4 CEP170P1 CEP44 CEP57L1 CHCHD3 DDIT4L DRC4 ERBIN EVI5 FBXO16 GABPB1 GATA3 GOLGA2 GPATCH2L GPRASP3 HDX HGS HMBOX1 HMG20A HNRNPH1 HNRNPM HOMEZ HSPB2 HSPB2-C11orf52 IKZF1 IKZF3 ISY1 KANK2 KCTD1 KIAA1328 KRABD4 KRT16 KRT40 KRT75 LDB1 LDB2 LPXN LYL1 LZTS1 LZTS2 MAD1L1 MBD3L1 MEOX2 MISP MSS51 NAGK NDUFA7 NHLH1 NTAQ1 NUTM1 PHC2 PICK1 POLR3GL PPP1R13B PRDM6 PSMB1 PTPN3 PXN RBBP8 RCN1 REL SAXO1 SNTA1 SOX5 SPG21 SYTL4 TADA2A TAL1 TAL2 TASOR2 TCF4 TCP10L TFIP11 TLE5 TRIM27 TRIM35 TRIM54 TSC22D4 UFSP2 UHMK1 UNKL UTP14A VBP1 WASHC1 ZBTB43 ZBTB8B ZCCHC12 ZFP90 ZNF143 ZNF177 ZNF19 ZNF219 ZNF24 ZNF354C ZNF417 ZNF460 ZNF511 ZNF526 ZNF559-ZNF177 ZNF620 ZNF641 ZNF688 ZNF76 ZNF84
Entrez ID		4807	4004
HPRD ID		01212	01738
Ensembl ID		ENSG00000171786	ENSG00000166407
Uniprot IDs		Q02575 Q5T203	E9PK83 P25800
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Neuron Fate Specification Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Glial Cell Fate Specification Nucleoplasm Cell Fate Specification Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Exit From Mitosis Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Generation Of Neurons Regulation Of Macromolecule Biosynthetic Process BHLH Transcription Factor Binding Glial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Lung Ciliated Cell Differentiation Positive Regulation Of Cardioblast Proliferation Positive Regulation Of Actin Filament Severing Regulation Of Gene Expression Positive Regulation Of Telomere Maintenance Retina Development In Camera-type Eye DNA Metabolic Process Cell Differentiation Involved In Salivary Gland Development Negative Regulation Of Mesenchymal Cell Proliferation Involved In Lung Development Negative Regulation Of Actin Filament Severing Nucleus Regulation Of Multicellular Organismal Process Regulation Of Stem Cell Proliferation Regulation Of T Cell Homeostatic Proliferation Neural Precursor Cell Proliferation Principal Sensory Nucleus Of Trigeminal Nerve Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Proteasome Activator Complex Vitamin D Response Element Binding Ventral Spinal Cord Interneuron Differentiation Positive Regulation Of Chromosome Organization	Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus DNA Binding Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Zinc Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Regulation Of Actin Nucleation Negative Regulation Of Metabolic Process Identical Protein Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Response To Muramyl Dipeptide Cytoskeleton Negative Regulation Of Macromolecule Biosynthetic Process Metal Ion Binding Regulation Of Arp2/3 Complex-mediated Actin Nucleation
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