NF1 and MYOG

Number of citations of the paper that reports this interaction (PMID 1329097)
21

Data Source:
BioGRID (pull down)

		NF1	MYOG
Gene Name		neurofibromin 1	myogenin (myogenic factor 4)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Membrane Axon Dendrite Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane	Nucleus Nucleoplasm Transcription Factor Complex Protein-DNA Complex
	Molecular Function	Ras GTPase Activator Activity Protein Binding Phosphatidylethanolamine Binding Phosphatidylcholine Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Chromatin DNA Binding Sequence-specific DNA Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	MAPK Cascade Osteoblast Differentiation Metanephros Development Response To Hypoxia Liver Development Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Cell Communication Ras Protein Signal Transduction Negative Regulation Of Neuroblast Proliferation Brain Development Peripheral Nervous System Development Heart Development Skeletal Muscle Tissue Development Visual Learning Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Schwann Cell Development Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Angiogenesis Spinal Cord Development Forebrain Astrocyte Development Neural Tube Development Cerebral Cortex Development Myelination In Peripheral Nervous System Actin Cytoskeleton Organization Extracellular Matrix Organization Collagen Fibril Organization Adrenal Gland Development Negative Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Regulation Of Ras GTPase Activity Positive Regulation Of Ras GTPase Activity Negative Regulation Of Rac Protein Signal Transduction Wound Healing Negative Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Neuron Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Bone Resorption Negative Regulation Of Osteoclast Differentiation Regulation Of Glial Cell Differentiation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Angiogenesis Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotransmitter Secretion Negative Regulation Of Fibroblast Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Sympathetic Nervous System Development Camera-type Eye Morphogenesis Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Smooth Muscle Tissue Development Artery Morphogenesis Forebrain Morphogenesis Cognition Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Ossification Cell Cycle Skeletal Muscle Tissue Development Negative Regulation Of Cell Proliferation Positive Regulation Of Myotube Differentiation Positive Regulation Of Muscle Atrophy Regulation Of Satellite Cell Proliferation Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Striated Muscle Atrophy Response To Denervation Involved In Regulation Of Muscle Adaptation Skeletal Muscle Cell Differentiation Muscle Cell Differentiation Muscle Cell Fate Commitment MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Skeletal Muscle Fiber Development Positive Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Cycle Arrest Cellular Response To Lithium Ion Cellular Response To Growth Factor Stimulus Cellular Response To Estradiol Stimulus Regulation Of Myoblast Fusion Positive Regulation Of Myoblast Fusion
Pathways			CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: APP DNAJC7 FAF2 GRIN1 GRIN2D HRAS MYOG SDC2 SMAD2 SMAD3 SMAD4 TBPL1 VCP	35 interactors: BBS4 CALM1 CALM2 CALM3 CARM1 CCDC28A CDH18 CLUAP1 CSRP3 EIF4E2 ELSPBP1 FTL HYPM ID1 ID2 ID3 IKBIP MAPK3 MDFI MEF2A MEF2C MLH1 NF1 PACRGL POLR2C PRMT5 SEPT5 SP1 SRF TAF6L TCF3 TRIM43 TTC25 TXNDC9 YME1L1
Entrez ID		4763	4656
HPRD ID		01203	01167
Ensembl ID		ENSG00000196712	ENSG00000122180
Uniprot IDs		P21359	P15173
PDB IDs		1NF1 2D4Q 2E2X 3P7Z 3PEG 3PG7
Enriched GO Terms of Interacting Partners?		SMAD Protein Complex Assembly Response To Abiotic Stimulus Cell Development Regulation Of Cell Development Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial To Mesenchymal Transition Response To Organic Substance Axon Guidance Cellular Component Assembly Regulation Of Cellular Component Organization Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Stem Cell Differentiation SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cell Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Primary MiRNA Processing Positive Regulation Of Macromolecule Biosynthetic Process Visual Learning Glutamate Receptor Signaling Pathway DNA-templated Transcription, Initiation Positive Regulation Of Gene Expression Axonogenesis Visual Behavior Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Cellular Response To Growth Factor Stimulus Protein Complex Assembly Axon Development Endoderm Development Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Embryonic Pattern Specification Response To Growth Factor Cell Differentiation Regulation Of Transforming Growth Factor Beta2 Production Paraxial Mesoderm Morphogenesis Chemotaxis Developmental Growth Associative Learning Positive Regulation Of Cellular Metabolic Process Neuron Projection Morphogenesis Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Ephrin Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation	Cell Activation Positive Regulation Of Phosphatase Activity Heart Development Organ Morphogenesis Positive Regulation Of Dephosphorylation Anatomical Structure Development Organ Development Cardiac Myofibril Assembly Determination Of Heart Left/right Asymmetry Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Anatomical Structure Morphogenesis Regulation Of Heart Contraction Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Cellular Metabolic Process Developmental Process Cardiovascular System Development Embryo Development Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Development Embryonic Organ Morphogenesis Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Binding Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Phosphatase Activity Organelle Organization System Development Determination Of Left/right Symmetry Multicellular Organismal Development Neurotrophin TRK Receptor Signaling Pathway Determination Of Bilateral Symmetry Neurotrophin Signaling Pathway Response To Calcium Ion Positive Regulation Of Lyase Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Growth Factor Stimulus Tissue Development Regulation Of Osteoblast Differentiation Response To Growth Factor Regulation Of Dephosphorylation Detection Of Calcium Ion Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Communication By Electrical Coupling Regulation Of Adenylate Cyclase Activity Muscle System Process Cell Development
Tagcloud ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink pepa pig prkca rara representatives sheep southern swine synteny tk1 umph2	boxes c2c12 c3h10t1 cardiotoxin colocalized dux4 duxbl dystrophy elongated embryogenesis facioscapulohumeral fshd homeobox homeodomain hyper multipotent muscles myoblast myocytes myod myogenesis myogenic myotubes organogenesis overexpressions quiescent regenerated satellite trunk
Tagcloud (Difference) ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink pepa pig prkca rara representatives sheep southern swine synteny tk1 umph2	boxes c2c12 c3h10t1 cardiotoxin colocalized dux4 duxbl dystrophy elongated embryogenesis facioscapulohumeral fshd homeobox homeodomain hyper multipotent muscles myoblast myocytes myod myogenesis myogenic myotubes organogenesis overexpressions quiescent regenerated satellite trunk
Tagcloud (Intersection) ?