NF1 and FAF2

Number of citations of the paper that reports this interaction (PMID 20160012)
14

Data Source:
BioGRID (enzymatic study)

		NF1	FAF2
Gene Name		neurofibromin 1	Fas associated factor family member 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Membrane Axon Dendrite Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane	Endoplasmic Reticulum Lipid Particle Cdc48p-Npl4p-Ufd1p AAA ATPase Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Ras GTPase Activator Activity Protein Binding Phosphatidylethanolamine Binding Phosphatidylcholine Binding	Protein Binding Ubiquitin Protein Ligase Binding Lipase Binding Ubiquitin Binding Lipase Inhibitor Activity
	Biological Process	MAPK Cascade Osteoblast Differentiation Metanephros Development Response To Hypoxia Liver Development Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Cell Communication Ras Protein Signal Transduction Negative Regulation Of Neuroblast Proliferation Brain Development Peripheral Nervous System Development Heart Development Skeletal Muscle Tissue Development Visual Learning Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Schwann Cell Development Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Angiogenesis Spinal Cord Development Forebrain Astrocyte Development Neural Tube Development Cerebral Cortex Development Myelination In Peripheral Nervous System Actin Cytoskeleton Organization Extracellular Matrix Organization Collagen Fibril Organization Adrenal Gland Development Negative Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Regulation Of Ras GTPase Activity Positive Regulation Of Ras GTPase Activity Negative Regulation Of Rac Protein Signal Transduction Wound Healing Negative Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Neuron Apoptotic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Bone Resorption Negative Regulation Of Osteoclast Differentiation Regulation Of Glial Cell Differentiation Positive Regulation Of Adenylate Cyclase Activity Regulation Of Angiogenesis Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotransmitter Secretion Negative Regulation Of Fibroblast Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Sympathetic Nervous System Development Camera-type Eye Morphogenesis Negative Regulation Of Astrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Smooth Muscle Tissue Development Artery Morphogenesis Forebrain Morphogenesis Cognition Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Response To Unfolded Protein Lipid Particle Organization Negative Regulation Of Catalytic Activity
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: APP DNAJC7 FAF2 GRIN1 GRIN2D HRAS MYOG SDC2 SMAD2 SMAD3 SMAD4 TBPL1 VCP	7 interactors: FAF1 FAS NF1 PNPLA2 PSMD2 UBE2D1 UBQLN2
Entrez ID		4763	23197
HPRD ID		01203	16870
Ensembl ID		ENSG00000196712	ENSG00000113194
Uniprot IDs		P21359	Q96CS3
PDB IDs		1NF1 2D4Q 2E2X 3P7Z 3PEG 3PG7	2DAM
Enriched GO Terms of Interacting Partners?		SMAD Protein Complex Assembly Response To Abiotic Stimulus Cell Development Regulation Of Cell Development Regulation Of Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Epithelial To Mesenchymal Transition Response To Organic Substance Axon Guidance Cellular Component Assembly Regulation Of Cellular Component Organization Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Stem Cell Differentiation SMAD Protein Signal Transduction Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cell Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Primary MiRNA Processing Positive Regulation Of Macromolecule Biosynthetic Process Visual Learning Glutamate Receptor Signaling Pathway DNA-templated Transcription, Initiation Positive Regulation Of Gene Expression Axonogenesis Visual Behavior Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Cellular Response To Growth Factor Stimulus Protein Complex Assembly Axon Development Endoderm Development Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Embryonic Pattern Specification Response To Growth Factor Cell Differentiation Regulation Of Transforming Growth Factor Beta2 Production Paraxial Mesoderm Morphogenesis Chemotaxis Developmental Growth Associative Learning Positive Regulation Of Cellular Metabolic Process Neuron Projection Morphogenesis Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Proliferation Ephrin Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation	Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Programmed Cell Death Cell Death Death Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Catalytic Activity Negative Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Signal Transduction Negative Regulation Of Protein Import Into Nucleus Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Negative Regulation Of Protein Localization To Nucleus Ubiquitin-dependent Protein Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Intracellular Protein Transport Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Transcription Factor Import Into Nucleus Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catalytic Activity Triglyceride Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Cell Death Forebrain Astrocyte Development Cellular Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death
Tagcloud ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink pepa pig prkca rara representatives sheep southern swine synteny tk1 umph2
Tagcloud (Difference) ?		american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink pepa pig prkca rara representatives sheep southern swine synteny tk1 umph2
Tagcloud (Intersection) ?