MYH11 and APC

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		MYH11	APC
Description		myosin heavy chain 11	APC regulator of Wnt signaling pathway
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Muscle Myosin Complex Myosin Complex Myosin II Complex Myosin Filament Melanosome Extracellular Exosome	Kinetochore Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Cytoplasmic Microtubule Plasma Membrane Adherens Junction Bicellular Tight Junction Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Catenin Complex Lamellipodium Cell Junction Beta-catenin Destruction Complex Leading Edge Membrane Ruffle Membrane Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction Plasma Membrane Bounded Cell Projection Wnt Signalosome
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Actin Filament Binding	Protein Binding Beta-catenin Binding Microtubule Binding Protein Kinase Regulator Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Gamma-catenin Binding Cadherin Binding Microtubule Plus-end Binding Dynein Complex Binding
	Biological Process	Smooth Muscle Contraction Skeletal Muscle Myosin Thick Filament Assembly Actomyosin Structure Organization Elastic Fiber Assembly Cardiac Muscle Cell Development	Mitotic Cytokinesis Cell Fate Specification Heart Valve Development Endocardial Cushion Morphogenesis DNA Damage Response Negative Regulation Of Microtubule Depolymerization Mitotic Spindle Assembly Checkpoint Signaling Cell Adhesion Pattern Specification Process Nervous System Development Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Wnt Signaling Pathway Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Regulation Of Microtubule-based Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Microtubule-based Movement Protein-containing Complex Assembly Bicellular Tight Junction Assembly Regulation Of Primary Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Localization To Centrosome Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs Developmental Lineage of Mammary Gland Myoepithelial Cells	Apoptotic cleavage of cellular proteins Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Deactivation of the beta-catenin transactivating complex Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants are not K63 polyubiquitinated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ovarian tumor domain proteases
Drugs		Tetrafluoroaluminate Ion
Diseases		Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)	Cancer of the anal canal Familial adenomatous polyposis Gastric cancer Esophageal cancer Gallbladder cancer
GWAS		Cognitive function ( 25644384) Coronary artery disease ( 33020668 29212778) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Haemorrhoidal disease ( 33888516) Multiple myeloma (survival) ( 26198393) Pelvic organ prolapse (moderate/severe) ( 26545240) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) PR interval ( 32439900) Pulse pressure ( 27841878 30578418) Resting heart rate ( 27798624 29769521) Serum immune biomarker levels ( 32066700) Serum uric acid levels in response to allopurinol in gout ( 25676789) Skin aging measurement ( 31522824) Waist-hip ratio ( 23966867)	Age at first sexual intercourse ( 34211149) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Appendicular lean mass ( 33097823) Body mass index ( 29273807) Colorectal cancer or advanced adenoma ( 30510241) Daytime nap ( 33568662) Heel bone mineral density ( 30598549) Reaction time ( 29844566) Total body bone mineral density ( 29304378)
Interacting Genes		4 interacting genes: APC DAXX GRB2 MAPKAPK5	135 interacting genes: ACTN1 ADGRL1 AGFG1 AGR3 ANKRD17 ANP32B ANXA7 AP2B1 ARHGEF4 ASAP2 ATOSA AXIN1 AXIN2 BAAT BUB1 BUB1B C4A CASC3 CCL5 CGNL1 COG4 COG5 CREBBP CSNK1A1 CSNK1E CTBP1 CTNNB1 CTSV CYP17A1 CYTH2 DIRAS3 DKK3 DLG1 DLG3 DLGAP1 DST EPAS1 ERBIN EXPH5 FANCC FBP1 FBXO30 FHOD1 FLNA GIGYF2 GOLGA2 GSK3B HGS HNRNPM HOXC6 HSPA5 HTRA2 IL24 ING5 IQGAP1 JUP KIF5B KIFAP3 KRT13 KRT14 KRT15 KRT17 KRT23 KRT5 LAMA3 LAMA4 MACF1 MAP2K1 MAPRE1 MAPRE2 MBD5 MCM3AP MKRN1 MT-ND4 MUC1 MYH10 MYH11 MYO6 NANS NAT2 NAV1 NAV2 NAV3 NCKAP5L NEB NOSTRIN NUP153 NUP214 NUP42 NUP54 NUP58 NUP98 PDLIM2 PKNOX1 PNISR POM121 POM121C PPP1R13B PPP2CA PPP2R5A PPP3R2 PRKACA PSMD1 PTPN13 RANBP9 RASA1 RBM4B RP1 RPS27 SCRIB SEC31A SETDB1 SIAH1 SMAD1 SMC3 SNRNP200 SPECC1L SPTBN1 SPTBN2 ST14 SYNE1 TAF1 TFAP2A TFF1 TGFB1 TMEFF1 TMOD1 TPR TRIM21 TRIM25 TSTD2 TUBA4A XPO1 ZNF106 ZNF510
Entrez ID		4629	324
HPRD ID		01174	01439
Ensembl ID		ENSG00000133392	ENSG00000134982
Uniprot IDs		A0A024QZJ4 P35749	P25054 R4GMU6
PDB IDs			1DEB 1EMU 1JPP 1M5I 1T08 1TH1 1V18 2RQU 3AU3 3NMW 3NMX 3NMZ 3QHE 3RL7 3RL8 3T7U 4G69 4YJE 4YJL 4YK6 5B6G 5IZ6 5IZ8 5IZ9 5IZA 5Z8H 7F6M 7F7O 7XTY 8GSJ 8X2Q
Enriched GO Terms of Interacting Partners?		Protein Kinase Binding Intracellular Signal Transduction Insulin Receptor Signaling Pathway P53 Binding Ras Protein Signal Transduction Guanyl-nucleotide Exchange Factor Adaptor Activity Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Intracellular Signaling Cassette Cellular Response To Diamide Grb2-EGFR Complex Septin Cytoskeleton Positive Regulation Of Cellular Component Organization Regulation Of Chromosome Organization Regulation Of Organelle Organization Response To Sodium Arsenite Cellular Response To Salt Cellular Response To Sodium Arsenite MAPK Cascade Small GTPase-mediated Signal Transduction Neurotrophin TRKA Receptor Binding Calcium-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Protein Localization To Centrosome Stress-induced Premature Senescence Ubiquitin Protein Ligase Binding Wnt Signalosome Leading Edge Membrane Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleoplasm Beta-catenin Destruction Complex Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cellular Response To Stress Gamma-catenin Binding Regulation Of Supramolecular Fiber Organization Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Centrosome Branching Involved In Labyrinthine Layer Morphogenesis Insulin Receptor Substrate Binding Tissue Morphogenesis Protein Kinase Regulator Activity Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Arsenic-containing Substance Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity MAP Kinase Kinase Activity Negative Regulation Of Microtubule Depolymerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Component Biogenesis	Organelle Organization Structural Constituent Of Nuclear Pore Cytoskeleton Organization Supramolecular Fiber Organization Cytosol MRNA Transport Nuclear Export Nuclear Pore Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Beta-catenin Destruction Complex Nuclear Transport Nucleocytoplasmic Transport RNA Transport Nuclear Membrane RNA Export From Nucleus Cellular Localization Cytoskeleton Intracellular Protein Localization Regulation Of Nucleocytoplasmic Transport Intracellular Transport Nucleobase-containing Compound Transport Nuclear Localization Sequence Binding Nuclear Envelope Establishment Of Localization In Cell Cadherin Binding Regulation Of Protein Localization Actin Filament Binding Glutamatergic Synapse Regulation Of Cellular Localization Protein Export From Nucleus Hemidesmosome Intracellular Protein Transport Actin Binding Nucleus Protein Transport Cellular Component Assembly Positive Regulation Of Nucleocytoplasmic Transport Establishment Of Protein Localization Cytoplasm Regulation Of Cytoskeleton Organization Canonical Wnt Signaling Pathway Regulation Of Intracellular Transport Structural Molecule Activity Intermediate Filament Organization Nuclear Pore Nuclear Basket Regulation Of Intracellular Protein Transport Nuclear Pore Organization Microtubule Regulation Of Centromeric Sister Chromatid Cohesion
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