MYH11

Name	myosin heavy chain 11
Structure	No pdb structure
Interactors	4 interactors: APC DAXX GRB2 MAPKAPK5
GO Annotations	Cellular Component	Cytoplasm Cytosol Muscle Myosin Complex Myosin Complex Myosin II Complex Myosin Filament Melanosome Extracellular Exosome
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Actin Filament Binding
	Biological Process	Smooth Muscle Contraction Skeletal Muscle Myosin Thick Filament Assembly Actomyosin Structure Organization Elastic Fiber Assembly Cardiac Muscle Cell Development
Pathways	EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs Developmental Lineage of Mammary Gland Myoepithelial Cells
Drugs	Tetrafluoroaluminate Ion
Diseases	Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS	Cognitive function ( 25644384 ) Coronary artery disease ( 33020668 29212778 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Haemorrhoidal disease ( 33888516 ) Multiple myeloma (survival) ( 26198393 ) Pelvic organ prolapse (moderate/severe) ( 26545240 ) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311 ) PR interval ( 32439900 ) Pulse pressure ( 27841878 30578418 ) Resting heart rate ( 27798624 29769521 ) Serum immune biomarker levels ( 32066700 ) Serum uric acid levels in response to allopurinol in gout ( 25676789 ) Skin aging measurement ( 31522824 ) Waist-hip ratio ( 23966867 )
Entrez ID	4629
HPRD ID	01174
Ensembl ID	ENSG00000133392
Uniprot IDs	A0A024QZJ4 P35749
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Protein Kinase Binding Intracellular Signal Transduction Insulin Receptor Signaling Pathway P53 Binding Ras Protein Signal Transduction Guanyl-nucleotide Exchange Factor Adaptor Activity Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Intracellular Signaling Cassette Cellular Response To Diamide Grb2-EGFR Complex Septin Cytoskeleton Positive Regulation Of Cellular Component Organization Regulation Of Chromosome Organization Regulation Of Organelle Organization Response To Sodium Arsenite Cellular Response To Salt Cellular Response To Sodium Arsenite MAPK Cascade Small GTPase-mediated Signal Transduction Neurotrophin TRKA Receptor Binding Calcium-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Protein Localization To Centrosome Stress-induced Premature Senescence Ubiquitin Protein Ligase Binding Wnt Signalosome Leading Edge Membrane Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Nucleoplasm Beta-catenin Destruction Complex Negative Regulation Of Cyclin-dependent Protein Kinase Activity Cellular Response To Stress Gamma-catenin Binding Regulation Of Supramolecular Fiber Organization Regulation Of Protein Metabolic Process Regulation Of Protein Localization To Centrosome Branching Involved In Labyrinthine Layer Morphogenesis Insulin Receptor Substrate Binding Tissue Morphogenesis Protein Kinase Regulator Activity Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Arsenic-containing Substance Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity MAP Kinase Kinase Activity Negative Regulation Of Microtubule Depolymerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Component Biogenesis