MYH11 and MAPKAPK5

Number of citations of the paper that reports this interaction (PMID 9628874)
65

Data Source:
HPRD (in vitro)

		MYH11	MAPKAPK5
Gene Name		myosin, heavy chain 11, smooth muscle	mitogen-activated protein kinase-activated protein kinase 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Cytosol Muscle Myosin Complex Smooth Muscle Contractile Fiber Myosin Filament Melanosome Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm
	Molecular Function	Motor Activity Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Actin Filament Binding	P53 Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Muscle Contraction Smooth Muscle Contraction Axon Guidance Metabolic Process Skeletal Muscle Myosin Thick Filament Assembly Ephrin Receptor Signaling Pathway Elastic Fiber Assembly Cardiac Muscle Fiber Development	MAPK Cascade Activation Of MAPK Activity Regulation Of Translation Signal Transduction Ras Protein Signal Transduction Negative Regulation Of TOR Signaling Protein Autophosphorylation Stress-induced Premature Senescence
Pathways		EPHA-mediated growth cone collapse Axon guidance Semaphorin interactions Smooth Muscle Contraction EPH-Ephrin signaling Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse	Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: APC DAXX GRB2 MAPKAPK5	28 interactors: ATF2 CDCA8 EEF2K EIF4E EIF4EBP1 GYS1 HSPB1 HSPB2 JUN LSR MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK4 MAPK6 MAPK9 MBP MYH11 PLA2G4A RPL13 SRPK1 SRPK2 TAB1 TP53 ZNF282 ZNF576
Entrez ID		4629	8550
HPRD ID		01174	09467
Ensembl ID		ENSG00000133392	ENSG00000089022
Uniprot IDs		P35749	Q8IW41
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Mitotic Cytokinesis Regulation Of Phosphorus Metabolic Process Cellular Response To Stress Regulation Of Intracellular Signal Transduction Cytokinesis Regulation Of Protein Kinase Activity Positive Regulation Of Protein Polymerization Regulation Of Kinase Activity Regulation Of Signal Transduction Activation Of MAPK Activity Regulation Of Signaling Positive Regulation Of Protein Complex Assembly Protein Complex Assembly Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Metabolic Process Response To Stress Negative Regulation Of Signaling Positive Regulation Of MAP Kinase Activity Ras Protein Signal Transduction Positive Regulation Of Protein Metabolic Process MAPK Cascade Negative Regulation Of Odontogenesis Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Component Biogenesis Metaphase/anaphase Transition Of Mitotic Cell Cycle Aging Regulation Of Protein Complex Assembly Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion Branching Involved In Labyrinthine Layer Morphogenesis Positive Regulation Of Organelle Organization Negative Regulation Of Intracellular Signal Transduction Stress-induced Premature Senescence Cell Division Intracellular Signal Transduction Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Microtubule Polymerization Cellular Component Assembly Positive Regulation Of MAPK Cascade Positive Regulation Of Pseudopodium Assembly Regulation Of Cellular Protein Metabolic Process	MAPK Cascade Signal Transduction By Phosphorylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Phosphorylation Regulation Of Innate Immune Response Response To Organic Substance Response To Stress Gene Expression Cellular Response To Organic Substance Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response Protein Phosphorylation Signaling Phosphate-containing Compound Metabolic Process Cell Cycle Cell Communication Ras Protein Signal Transduction Innate Immune Response Signal Transduction Mitochondrion Organization Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Apoptotic Mitochondrial Changes Defense Response Response To Toxic Substance Cellular Response To Stimulus Response To Stimulus
Tagcloud ?		abi1 atlas bitbucket ccnd3 ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf org pparg prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript	acids amino blot designated encodes erk gst homology identities jnk jun kinase light mitogen myosin northern novel nucleotide p38 phosphorylate phosphorylated recombinant sequence shares substrate wide
Tagcloud (Difference) ?		abi1 atlas bitbucket ccnd3 ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf org pparg prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript	acids amino blot designated encodes erk gst homology identities jnk jun kinase light mitogen myosin northern novel nucleotide p38 phosphorylate phosphorylated recombinant sequence shares substrate wide
Tagcloud (Intersection) ?