MYOM1 and TTN

Number of citations of the paper that reports this interaction (PMID 7588733)
7

Data Source:
HPRD (in vitro)

		MYOM1	TTN
Gene Name		myomesin 1	titin
Image
Gene Ontology Annotations	Cellular Component	Striated Muscle Myosin Thick Filament M Band	Condensed Nuclear Chromosome Extracellular Region Cytosol Striated Muscle Thin Filament Z Disc M Band I Band Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity	Protease Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Enzyme Binding Protein Kinase Binding Telethonin Binding Identical Protein Binding Actinin Binding Protein Self-association Actin Filament Binding Muscle Alpha-actinin Binding Structural Molecule Activity Conferring Elasticity
	Biological Process	Muscle Contraction	Platelet Degranulation Cardiac Muscle Hypertrophy Muscle Contraction Striated Muscle Contraction Mitotic Chromosome Condensation Blood Coagulation Peptidyl-tyrosine Phosphorylation Muscle Filament Sliding Platelet Activation Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Detection Of Muscle Stretch Sarcomere Organization Regulation Of Protein Kinase Activity Cardiac Muscle Fiber Development Sarcomerogenesis Regulation Of Catalytic Activity Response To Calcium Ion Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways			Striated Muscle Contraction Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			Breast size ( 22747683) QT interval ( 20031603)
Protein-Protein Interactions		2 interactors: MYH9 TTN	29 interactors: ACTA1 ACTN1 ACTN2 ANK1 ANKRD1 ANKRD2 ANKRD23 CALM1 CAPN3 CRYAB FHL1 FHL2 FLNA MAPK1 MYBPC1 MYBPC3 MYH9 MYOM1 MYOM2 MYPN NBR1 NEB OBSCN SQSTM1 SRPK2 TCAP TRIM55 TRIM63 VAV2
Entrez ID		8736	7273
HPRD ID		04618	01787
Ensembl ID		ENSG00000101605	ENSG00000155657
Uniprot IDs		P52179	Q7Z3B7 Q8WZ42
PDB IDs		2R15 2Y23 2Y25 3RBS	1BPV 1G1C 1NCT 1NCU 1TIT 1TIU 1TKI 1TNM 1TNN 1WAA 1YA5 2A38 2BK8 2F8V 2ILL 2J8H 2J8O 2NZI 2RQ8 2WP3 2WWK 2WWM 2Y9R 3B43 3KNB 3LCY 3LPW 3PUC 3Q5O 3QP3
Enriched GO Terms of Interacting Partners?		Actin Filament-based Movement Actomyosin Structure Organization Platelet Activation Striated Muscle Cell Differentiation Muscle Cell Differentiation Sarcomerogenesis Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Directional Locomotion Blood Coagulation Hemostasis Myosin Filament Assembly Establishment Of T Cell Polarity Uropod Organization Establishment Of Meiotic Spindle Localization Muscle Structure Development In Utero Embryonic Development Skeletal Muscle Thin Filament Assembly Regulation Of Body Fluid Levels Wound Healing Actin Cytoskeleton Organization Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Actin Filament-based Process Cell Activation Response To Wounding Meiotic Spindle Organization Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Cardiovascular System Development Adult Heart Development Monocyte Differentiation Membrane Protein Ectodomain Proteolysis Myoblast Fusion Platelet Formation Cardiac Myofibril Assembly Platelet Morphogenesis Cell Cycle Process Anatomical Structure Formation Involved In Morphogenesis Cardiac Muscle Hypertrophy Mitotic Chromosome Condensation Cytoskeleton Organization Muscle Hypertrophy Embryo Development Muscle Filament Sliding Actin-myosin Filament Sliding Syncytium Formation Blood Vessel Endothelial Cell Migration Locomotion	Muscle Contraction Muscle System Process Muscle Structure Development Actin Filament-based Process Actomyosin Structure Organization Actin Filament-based Movement Actin-myosin Filament Sliding Muscle Filament Sliding Myofibril Assembly Striated Muscle Cell Differentiation Striated Muscle Cell Development Actin-mediated Cell Contraction Muscle Cell Development Sarcomere Organization Muscle Organ Development Muscle Cell Differentiation Cellular Component Assembly Actin Cytoskeleton Organization Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Morphogenesis Cytoskeleton Organization Platelet Activation Cell Differentiation Cell Development Organelle Assembly Developmental Process Anatomical Structure Development Organ Development Blood Coagulation Hemostasis System Development Multicellular Organismal Development Platelet Degranulation Striated Muscle Tissue Development Response To Stress Muscle Tissue Development Response To Abiotic Stimulus Regulation Of Apoptotic Process Response To External Stimulus Regulation Of Body Fluid Levels Organelle Organization Neurotrophin TRK Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Response To Stimulus Wound Healing Cardiovascular System Development Neurotrophin Signaling Pathway Regulation Of Cell Death Regulation Of Intracellular Transport Cell Activation
Tagcloud ?		18p11 aided blindness cataracts centimorgans chorioretinal clul1 compiled dlgap1 elastin emilin2 interfacer intronic lipin lpin2 microfibril mrcl3 mrlc2 myomesin myopia myosin myp2 pedigree positional prioritizing segregated tgifbeta underway zfp161	amounts anticancer atlas braf broad diverse exome frequencies frequency frg1b harbored includes integrated lineage metastastic muc16 mutated mutational obtain omics pbrm1 resource sequencing somatic subtypes summarized ush2a varied vhl
Tagcloud (Difference) ?		18p11 aided blindness cataracts centimorgans chorioretinal clul1 compiled dlgap1 elastin emilin2 interfacer intronic lipin lpin2 microfibril mrcl3 mrlc2 myomesin myopia myosin myp2 pedigree positional prioritizing segregated tgifbeta underway zfp161	amounts anticancer atlas braf broad diverse exome frequencies frequency frg1b harbored includes integrated lineage metastastic muc16 mutated mutational obtain omics pbrm1 resource sequencing somatic subtypes summarized ush2a varied vhl
Tagcloud (Intersection) ?