MYL9 and CDC42BPA

Number of citations of the paper that reports this interaction (PubMedID 11283256)
48

Data Source:
HPRD (in vitro)

		MYL9	CDC42BPA
Description		myosin light chain 9	CDC42 binding protein kinase alpha
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Muscle Myosin Complex Cell Cortex Myosin Complex Myosin II Complex Myofibril Z Disc	Cytoplasm Cytosol Cytoskeleton Cell-cell Junction Lamellipodium Cell Leading Edge Actomyosin Cell Projection Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Muscle Contraction Myofibril Assembly Stress Fiber Assembly Platelet Aggregation	Protein Phosphorylation Cytoskeleton Organization Cell Migration Actin Cytoskeleton Organization Actomyosin Structure Organization
Pathways		EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle
Drugs
Diseases
GWAS			Blond vs. brown/black hair color ( 30531825) Blood urea nitrogen levels ( 31152163) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Diastolic blood pressure ( 28135244) Low density lipoprotein cholesterol levels ( 33339817) Macular thickness ( 30535121) Mercury levels ( 26025379) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Optic cup area ( 25631615 31798171) Optic disc area ( 25631615 31798171 28073927) Optic disc size ( 31809533) SAPHO syndrome ( 33816493) Smoking initiation ( 33082346) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: CDC42BPA HSPB1 LRRK2 MSGN1 MYH9 PRPF19 TXN2	10 interacting genes: CDC42 LIMK1 LIMK2 MYL2 MYL9 PPM1A PPP1R12C SNAPIN TAF1 USP7
Entrez ID		10398	8476
HPRD ID		17619	04562
Ensembl ID		ENSG00000101335	ENSG00000143776
Uniprot IDs		A0A384NY64 P24844	A0A0A0MRJ0 A0A0A0MRJ1 Q5VT25
PDB IDs
Enriched GO Terms of Interacting Partners?		Actomyosin Cytoskeleton Negative Regulation Of Protein Kinase C Signaling Platelet Aggregation Spindle Homotypic Cell-cell Adhesion Regulation Of Protein Processing Cell Leading Edge Cortical Granule Exocytosis Regulation Of Protein Maturation Cell Projection Thermosensory Behavior Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Regulation Of Anatomical Structure Morphogenesis Uropod Organization Negative Regulation Of Actin Filament Severing Positive Regulation Of Protein Processing In Phagocytic Vesicle Regulation Of Cellular PH Regulation Of Intracellular PH Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Beta-catenin Destruction Complex Binding Intracellular Protein Localization Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Kinase C Inhibitor Activity Identical Protein Binding Myosin II Filament Actomyosin Structure Organization Regulation Of Centriole-centriole Cohesion Regulation Of PH Positive Regulation Of Protein Autoubiquitination Response To Curcumin Actomyosin Contractile Ring Regulation Of Protein Kinase C Signaling Cortical Granule Cytoplasmic Actin-based Contraction Involved In Cell Motility Regulation Of Postsynapse Organization Cytoplasmic Side Of Mitochondrial Outer Membrane Positive Regulation Of Dopamine Receptor Signaling Pathway Multivesicular Body, Internal Vesicle Regulation Of CAMKK-AMPK Signaling Cascade Regulation Of Branching Morphogenesis Of A Nerve Regulation Of Synaptic Vesicle Transport	Actin Filament-based Process Actin Cytoskeleton Organization Supramolecular Fiber Organization Myosin Heavy Chain Binding Actomyosin Structure Organization Heart Contraction Cytoskeleton Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Organelle Organization Cytoskeleton Organization Myofibril Assembly Heart Process Structural Constituent Of Muscle Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Stress Fiber Assembly Actin Filament Organization Establishment Of Organelle Localization Regulation Of Cell Projection Organization Myosin Complex Myofibril Regulation Of Intracellular Transport Positive Regulation Of Actin Filament Bundle Assembly Actin Filament Bundle Assembly Muscle Cell Fate Specification Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Late Endosome To Lysosome Transport Actin Filament Bundle Organization P53 Binding Cellular Component Assembly Protein Serine Kinase Activity Protein Phosphorylation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cellular Component Organization GBD Domain Binding Storage Vacuole Organelle Transport Along Microtubule Negative Regulation Of Protein Autoubiquitination Stress Fiber Phosphorylation Protein Modification Process Regulation Of Cell Growth Regulation Of Stress Fiber Assembly Protein Serine/threonine Kinase Activity Developmental Process Endothelin Receptor Signaling Pathway Involved In Heart Process Establishment Of Vesicle Localization Symbiont-mediated Disruption Of Host Cell PML Body Organelle Localization
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