MYF5 and ITGB4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MYF5	ITGB4
Description		myogenic factor 5	integrin subunit beta 4
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex	Basement Membrane Nucleolus Plasma Membrane Focal Adhesion Integrin Complex Basal Plasma Membrane Cell Surface Membrane Cell Junction Hemidesmosome Cell Leading Edge Nuclear Membrane Receptor Complex Extracellular Exosome Anchoring Junction
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding	G Protein-coupled Receptor Binding Integrin Binding Protein Binding Insulin-like Growth Factor I Binding Neuregulin Binding Metal Ion Binding
	Biological Process	Cartilage Condensation Ossification Somitogenesis Regulation Of Cell-matrix Adhesion Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Skeletal Muscle Tissue Development Tissue Development Cell Differentiation Extracellular Matrix Organization Skeletal Muscle Cell Differentiation Muscle Cell Fate Commitment Camera-type Eye Development Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Muscle Organ Morphogenesis Embryonic Skeletal System Morphogenesis Positive Regulation Of Skeletal Muscle Fiber Development Muscle Tissue Morphogenesis	Autophagy Cell Communication Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Response To Wounding Cell Migration Myelination In Peripheral Nervous System Hemidesmosome Assembly Peripheral Nervous System Myelin Formation Cell Adhesion Mediated By Integrin Nail Development Skin Morphogenesis Filopodium Assembly Mesodermal Cell Differentiation Cell Motility Trophoblast Cell Migration Cell-cell Adhesion
Pathways		Myogenesis Myogenesis TGFBR3 expression	Assembly of collagen fibrils and other multimeric structures Laminin interactions Syndecan interactions Type I hemidesmosome assembly Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs			R1295
Diseases			Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS
Interacting Genes		34 interacting genes: ANKRD11 AQP1 C14orf119 CALM1 CALM2 CALM3 CCDC13 CHIC2 CSNK2A1 CSNK2A2 ENKD1 FAM124B FIGLA ID1 ID2 ID3 ITGB4 MDFI MSGN1 NHLH2 PACRGL PIN1 RARG SCX SGF29 SNAPC5 TCEANC TCF3 TLE5 ZNF250 ZNF417 ZNF575 ZNF587 ZNF835	60 interacting genes: ADAMTSL4 ALOX12 APPBP2 ATXN1 CLCA1 CLCA2 COL17A1 CYSRT1 DST ECM1 EIF6 ERBB2 ERBIN FYN GRB2 HOXA1 ITGA6 KPRP KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP15-1 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP4-2 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 MDFI MET MID2 MTUS2 MYF5 NBPF19 NOTCH2NLA PLEC PLSCR4 POU2AF1 PRKCA PRKCD PTK2 SDC2 SDC3 SHC1 SREBF2 TGM1 TRIP6 VIM YES1 YWHAB YWHAQ
Entrez ID		4617	3691
HPRD ID		01168	00946
Ensembl ID		ENSG00000111049	ENSG00000132470
Uniprot IDs		P13349	B7ZLD8 P16144
PDB IDs		7Z5I 7Z5K	1QG3 2YRZ 3F7P 3F7Q 3F7R 3FQ4 3FSO 3H6A 4Q58 4WTW 4WTX 6GVK 6GVL
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity Nucleus Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane BHLH Transcription Factor Binding Regulation Of RNA Metabolic Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Transcription Regulator Inhibitor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Titin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Detection Of Calcium Ion Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Animal Organ Morphogenesis Calyx Of Held Protein Kinase CK2 Complex Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Calcineurin-mediated Signaling Presynaptic Cytosol Regulation Of Cell Division Regulation Of Cytokinesis Myelin Sheath DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Primary Metabolic Process Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cell Cycle Process Positive Regulation Of Sequestering Of Calcium Ion Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Negative Regulation Of Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression	Intermediate Filament Keratin Filament Identical Protein Binding Hemidesmosome Cytosol Establishment Of Skin Barrier Cell-substrate Junction Assembly Skin Epidermis Development Cell-substrate Junction Organization Epidermis Development Hemidesmosome Assembly Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Focal Adhesion Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Protein Tyrosine Kinase Activity Fc-gamma Receptor Signaling Pathway ERBB Signaling Pathway Anchoring Junction Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Protein Kinase C Signaling Ephrin Receptor Binding Regulation Of Reactive Oxygen Species Metabolic Process Intermediate Filament Organization Regulation Of Platelet Aggregation Neurotrophin TRKA Receptor Binding Cell Junction Organization Insulin-like Growth Factor Receptor Signaling Pathway Cellular Response To Fluid Shear Stress Cell Junction Assembly Regulation Of Cell-cell Adhesion Integrin-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway CD4 Receptor Binding Immune Effector Process Structural Constituent Of Cytoskeleton Protein Binding Response To Fluid Shear Stress Enzyme Binding T Cell Costimulation Negative Regulation Of Glial Cell Apoptotic Process Phosphotyrosine Residue Binding Negative Regulation Of Platelet Aggregation Intermediate Filament Cytoskeleton Peptidyl-tyrosine Phosphorylation
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