MYF5 and NHLH2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MYF5	NHLH2
Description		myogenic factor 5	nescient helix-loop-helix 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Cartilage Condensation Ossification Somitogenesis Regulation Of Cell-matrix Adhesion Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Skeletal Muscle Tissue Development Tissue Development Cell Differentiation Extracellular Matrix Organization Skeletal Muscle Cell Differentiation Muscle Cell Fate Commitment Camera-type Eye Development Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Muscle Organ Morphogenesis Embryonic Skeletal System Morphogenesis Positive Regulation Of Skeletal Muscle Fiber Development Muscle Tissue Morphogenesis	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Central Nervous System Development Peripheral Nervous System Development Male Gonad Development Cell Migration In Hindbrain Hypothalamus Gonadotrophin-releasing Hormone Neuron Development Cell Differentiation Ovulation Cycle Positive Regulation Of Transcription By RNA Polymerase II Male Mating Behavior
Pathways		Myogenesis Myogenesis TGFBR3 expression
Drugs
Diseases
GWAS			Electrocardiographic traits (multivariate) ( 32602732) Heart rate variability traits (SDNN) ( 28610988) Metabolite levels ( 23823483)
Interacting Genes		34 interacting genes: ANKRD11 AQP1 C14orf119 CALM1 CALM2 CALM3 CCDC13 CHIC2 CSNK2A1 CSNK2A2 ENKD1 FAM124B FIGLA ID1 ID2 ID3 ITGB4 MDFI MSGN1 NHLH2 PACRGL PIN1 RARG SCX SGF29 SNAPC5 TCEANC TCF3 TLE5 ZNF250 ZNF417 ZNF575 ZNF587 ZNF835	8 interacting genes: CFTR HES1 KCNIP1 LMO3 MYF5 TAF1D TCF12 TCF4
Entrez ID		4617	4808
HPRD ID		01168	01213
Ensembl ID		ENSG00000111049	ENSG00000177551
Uniprot IDs		P13349	Q02577
PDB IDs		7Z5I 7Z5K
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity Nucleus Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane BHLH Transcription Factor Binding Regulation Of RNA Metabolic Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Transcription Regulator Inhibitor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Titin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Detection Of Calcium Ion Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Animal Organ Morphogenesis Calyx Of Held Protein Kinase CK2 Complex Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Calcineurin-mediated Signaling Presynaptic Cytosol Regulation Of Cell Division Regulation Of Cytokinesis Myelin Sheath DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Primary Metabolic Process Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cell Cycle Process Positive Regulation Of Sequestering Of Calcium Ion Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Negative Regulation Of Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression	E-box Binding Protein Dimerization Activity Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Monoatomic Ion Transport Regulation Of Developmental Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Negative Regulation Of Pancreatic A Cell Differentiation Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Oculomotor Nerve Development N-box Binding Negative Regulation Of Cell Fate Determination Regulation Of RNA Biosynthetic Process Chromatin Positive Regulation Of RNA Metabolic Process Cajal-Retzius Cell Differentiation Positive Regulation Of Mitotic Cell Cycle, Embryonic Negative Regulation Of Forebrain Neuron Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hindbrain Morphogenesis Trochlear Nerve Development Renal Interstitial Fibroblast Development Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Neuron Differentiation Kv4.3-KChIP1 Channel Complex Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein-folding Chaperone Binding Positive Regulation Of Enamel Mineralization Positive Regulation Of Monoatomic Anion Transport Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Ureteric Bud Morphogenesis Regulation Of RNA Metabolic Process DNA Binding Negative Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Amacrine Cell Differentiation Nervous System Development Negative Regulation Of Pro-B Cell Differentiation
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