MYF5 and SCX

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MYF5	SCX
Description		myogenic factor 5	scleraxis bHLH transcription factor
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding
	Biological Process	Cartilage Condensation Ossification Somitogenesis Regulation Of Cell-matrix Adhesion Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Skeletal Muscle Tissue Development Tissue Development Cell Differentiation Extracellular Matrix Organization Skeletal Muscle Cell Differentiation Muscle Cell Fate Commitment Camera-type Eye Development Positive Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development Muscle Organ Morphogenesis Embryonic Skeletal System Morphogenesis Positive Regulation Of Skeletal Muscle Fiber Development Muscle Tissue Morphogenesis	Mesoderm Formation Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Valve Morphogenesis Heart Valve Formation DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Differentiation Collagen Fibril Organization BMP Signaling Pathway Developmental Process Positive Regulation Of Collagen Biosynthetic Process Skeletal Muscle Cell Differentiation Tendon Development Tendon Cell Differentiation Tendon Formation Deltoid Tuberosity Development Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Development Sertoli Cell Differentiation Sertoli Cell Development Face Morphogenesis Regulation Of Cartilage Development Positive Regulation Of Cartilage Development Sclerotome Development Cellular Response To Mechanical Stimulus Cellular Response To CAMP Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Gastrulation
Pathways		Myogenesis Myogenesis TGFBR3 expression
Drugs
Diseases
GWAS
Interacting Genes		34 interacting genes: ANKRD11 AQP1 C14orf119 CALM1 CALM2 CALM3 CCDC13 CHIC2 CSNK2A1 CSNK2A2 ENKD1 FAM124B FIGLA ID1 ID2 ID3 ITGB4 MDFI MSGN1 NHLH2 PACRGL PIN1 RARG SCX SGF29 SNAPC5 TCEANC TCF3 TLE5 ZNF250 ZNF417 ZNF575 ZNF587 ZNF835	4 interacting genes: MYF5 NCK2 TCF3 TCF4
Entrez ID		4617	642658
HPRD ID		01168	19332
Ensembl ID		ENSG00000111049	ENSG00000260428
Uniprot IDs		P13349	Q7RTU7
PDB IDs		7Z5I 7Z5K
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Protein Dimerization Activity Nucleus Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane BHLH Transcription Factor Binding Regulation Of RNA Metabolic Process Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Transcription Regulator Inhibitor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Titin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Detection Of Calcium Ion Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Animal Organ Morphogenesis Calyx Of Held Protein Kinase CK2 Complex Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Calcium Channel Complex Calcineurin-mediated Signaling Presynaptic Cytosol Regulation Of Cell Division Regulation Of Cytokinesis Myelin Sheath DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Primary Metabolic Process Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cell Cycle Process Positive Regulation Of Sequestering Of Calcium Ion Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Negative Regulation Of Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression	E-box Binding Protein Dimerization Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Cell Differentiation Cell Fate Commitment Positive Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Regulation Of Neuron Differentiation Beta-catenin-TCF7L2 Complex Vitamin D Response Element Binding Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TFIIB-class Transcription Factor Binding Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Mononuclear Cell Proliferation B Cell Lineage Commitment Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Leukocyte Proliferation Positive Regulation Of Translation In Response To Stress Positive Regulation Of Skeletal Muscle Fiber Development Muscle Organ Morphogenesis Positive Regulation Of Developmental Process Immunoglobulin V(D)J Recombination Signal Complex Assembly Regulation Of Nucleobase-containing Compound Metabolic Process Protein Heterodimerization Activity Positive Regulation Of Lymphocyte Activation Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Differentiation
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