AOC3 and PRRG4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		AOC3	PRRG4
Description		amine oxidase copper containing 3	proline rich and Gla domain 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Microvillus Cell Surface Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Copper Ion Binding Calcium Ion Binding Protein Binding Primary Methylamine Oxidase Activity Oxidoreductase Activity Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity Quinone Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding WW Domain Binding
	Biological Process	Inflammatory Response Cell Adhesion Amine Metabolic Process	Proteolysis Blood Coagulation
Pathways		Phase I - Functionalization of compounds
Drugs		Phenelzine Hydralazine 6-hydroxydopa quinone
Diseases
GWAS			Parkinson's disease (age of onset) ( 19772629) Platelet count ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		13 interacting genes: ARL13B CLDN9 CPLX4 CREB3L1 DARS2 FNDC9 HSD17B13 LMNA MYBPC2 PRRG4 SGTA STX1A VAV1	30 interacting genes: ABL2 AOC3 ARHGEF7 BCL10 ERBB3 ERBB4 FYN GRAP GRB2 HCK HDAC1 HECW1 HLA-C ITCH ITSN1 LYN MAGI2 MAGI3 NEBL NEDD4 OSTF1 PEX13 RBBP8 TEC UBE2K VAV2 VEGFA WWP1 WWTR1 YAP1
Entrez ID		8639	79056
HPRD ID		04770	15187
Ensembl ID		ENSG00000131471	ENSG00000135378
Uniprot IDs		Q16853 Q9UEU7	A0A0S2Z5M6 A0A0S2Z5N9 Q9BZD6
PDB IDs		1PU4 1US1 2C10 2C11 2Y73 2Y74 3ALA 4BTW 4BTX 4BTY 8S1Z
Enriched GO Terms of Interacting Partners?			Signal Transduction Intracellular Signal Transduction Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Signal Transduction Positive Regulation Of Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Modification Process Epidermal Growth Factor Receptor Binding Fc-gamma Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Activation Of Immune Response Regulation Of Cell Communication Regulation Of Signaling Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Cytoplasm Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fc Receptor Signaling Pathway Regulation Of Immune Response Proline-rich Region Binding Epidermal Growth Factor Receptor Signaling Pathway Cytosol Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Adhesion Plasma Membrane Neuregulin Receptor Activity Regulation Of Neuron Projection Development Regulation Of Immune System Process Protein Ubiquitination ERBB Signaling Pathway Regulation Of Cell Activation Adaptive Immune Response Positive Regulation Of Defense Response Receptor-mediated Endocytosis Negative Regulation Of Apoptotic Process
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