ACO1 and CCDC69

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		ACO1	CCDC69
Description		aconitase 1	coiled-coil domain containing 69
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Extracellular Exosome	Nucleus Cytoplasm Spindle Cytoskeleton Midbody Spindle Midzone
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity RNA Binding Aconitate Hydratase Activity Protein Binding Lyase Activity Iron-responsive Element Binding Metal Ion Binding Iron-sulfur Cluster Binding 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Microtubule Binding
	Biological Process	Tricarboxylic Acid Cycle Citrate Metabolic Process Regulation Of Translation NADPH Regeneration Intracellular Iron Ion Homeostasis Post-embryonic Development Response To Iron(II) Ion Regulation Of Gene Expression Negative Regulation Of Translation Intestinal Absorption	Spindle Midzone Assembly
Pathways		NADPH regeneration Iron uptake and transport
Drugs
Diseases
GWAS		Asthma ( 22561531) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Immune response to measles-mumps-rubella vaccine ( 24811271) Inflammatory skin disease ( 25574825) Lateral ventricle temporal horn volume ( 31530798) Motion sickness ( 25628336) Red blood cell count ( 27863252 32888494) Smoking status (ever vs never smokers) ( 30643258)	Bulimia nervosa ( 23568457) Chronic obstructive pulmonary disease ( 30804561) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Loneliness (linear analysis) ( 27629369) Lymphocyte count ( 32888494) Monocyte count ( 27863252 32888494) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Red cell distribution width ( 32888494) White blood cell count ( 27863252 32888494)
Interacting Genes		10 interacting genes: APP CCDC69 CDC42 CLTC DSCAM FTL MYBPC1 NEB PXN RNF10	5 interacting genes: ACO1 MAP3K1 MAP3K20 PSMA3 SMURF1
Entrez ID		48	26112
HPRD ID		00013	13152
Ensembl ID		ENSG00000122729	ENSG00000198624
Uniprot IDs		P21399 Q9HBB2 V9HWB7	A6NI79 Q7L2X4
PDB IDs		2B3X 2B3Y
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Cell Projection Morphogenesis Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Low-density Lipoprotein Particle Receptor Binding Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Neuron Recognition Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Spindle Spindle Midzone Positive Regulation Of Actin Filament Bundle Assembly Iron Ion Transport Myofibril Structural Constituent Of Muscle Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization Cellular Component Assembly Clathrin-coated Pit Cell Adhesion Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process GBD Domain Binding Storage Vacuole Cytoskeleton Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Ferritin Complex Regulation Of Supramolecular Fiber Organization PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cell Recognition Lysosome Dendrite Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Neuron Projection Development Endocytosis	MAP Kinase Kinase Kinase Activity 3 Iron, 4 Sulfur Cluster Binding Citrate Metabolic Process Negative Regulation Of Translation Aconitate Hydratase Activity Iron-responsive Element Binding GCN2-mediated Signaling Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Stalled Ribosome Sensor Activity Positive Regulation Of Mitotic DNA Damage Checkpoint Engulfment Of Target By Autophagosome Positive Regulation Of DNA Damage Checkpoint Phosphate-containing Compound Metabolic Process MRNA Regulatory Element Binding Translation Repressor Activity Response To Iron(II) Ion NADPH Regeneration Tricarboxylic Acid Metabolic Process Cytosol Protein Serine/threonine Kinase Activity MAPK Cascade Phosphorylation Protein Phosphorylation Protein Metabolic Process Protein Serine Kinase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasome Core Complex, Alpha-subunit Complex Regulation Of Translation In Response To Endoplasmic Reticulum Stress Protein Kinase Regulator Activity Cellular Response To UV-B JUN Kinase Kinase Kinase Activity Negative Regulation Of Translation In Response To Stress Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Small Ribosomal Subunit RRNA Binding NLRP1 Inflammasome Complex Assembly Positive Regulation Of Cell Cycle Checkpoint Activin Receptor Binding I-SMAD Binding Protein Targeting To Vacuole Involved In Autophagy Ectoderm Development Negative Regulation Of Activin Receptor Signaling Pathway Substrate Localization To Autophagosome Transforming Growth Factor Beta Receptor Binding Regulation Of Translation Proteasome Core Complex Receptor Catabolic Process Positive Regulation Of Dendrite Extension Regulation Of Protein Metabolic Process Protein Modification Process Fc-epsilon Receptor Signaling Pathway Proteasomal Protein Catabolic Process
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