ACO1

Name	aconitase 1
Structure
Interactors	10 interactors: APP CCDC69 CDC42 CLTC DSCAM FTL MYBPC1 NEB PXN RNF10
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Extracellular Exosome
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity RNA Binding Aconitate Hydratase Activity Protein Binding Lyase Activity Iron-responsive Element Binding Metal Ion Binding Iron-sulfur Cluster Binding 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Tricarboxylic Acid Cycle Citrate Metabolic Process Regulation Of Translation NADPH Regeneration Intracellular Iron Ion Homeostasis Post-embryonic Development Response To Iron(II) Ion Regulation Of Gene Expression Negative Regulation Of Translation Intestinal Absorption
Pathways	NADPH regeneration Iron uptake and transport
GWAS	Asthma ( 22561531 ) Hematocrit ( 27863252 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) Immune response to measles-mumps-rubella vaccine ( 24811271 ) Inflammatory skin disease ( 25574825 ) Lateral ventricle temporal horn volume ( 31530798 ) Motion sickness ( 25628336 ) Red blood cell count ( 27863252 32888494 ) Smoking status (ever vs never smokers) ( 30643258 )
Entrez ID	48
HPRD ID	00013
Ensembl ID	ENSG00000122729
Uniprot IDs	P21399 Q9HBB2 V9HWB7
PDB IDs	2B3X 2B3Y
GO Terms Enriched among Interactors ?	Amyloid-beta Complex Cell Projection Morphogenesis Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Low-density Lipoprotein Particle Receptor Binding Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Neuron Recognition Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Spindle Spindle Midzone Positive Regulation Of Actin Filament Bundle Assembly Iron Ion Transport Myofibril Structural Constituent Of Muscle Acetylcholine Receptor Activator Activity Regulation Of Cellular Component Organization Cellular Component Assembly Clathrin-coated Pit Cell Adhesion Lipoprotein Particle Positive Regulation Of Protein Import Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process GBD Domain Binding Storage Vacuole Cytoskeleton Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Ferritin Complex Regulation Of Supramolecular Fiber Organization PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cell Recognition Lysosome Dendrite Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Neuron Projection Development Endocytosis