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MT2A and SHBG
Number of citations of the paper that reports this interaction (PubMedID
15862967
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
MT2A
SHBG
Description
metallothionein 2A
sex hormone binding globulin
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Extracellular Region
Extracellular Exosome
Molecular Function
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Steroid Binding
Androgen Binding
Protein Binding
Lipid Binding
Biological Process
Intracellular Copper Ion Homeostasis
Intracellular Zinc Ion Homeostasis
Detoxification Of Copper Ion
Cellular Response To Interleukin-3
Cellular Response To Erythropoietin
Negative Regulation Of Growth
Cellular Response To Cadmium Ion
Cellular Response To Copper Ion
Cellular Response To Zinc Ion
Pathways
Metallothioneins bind metals
Metallothioneins bind metals
Interferon gamma signaling
Drugs
Zinc
Silver
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Masoprocol
Diethylstilbestrol
Levonorgestrel
Progesterone
Spironolactone
Toremifene
Estrone
Tamoxifen
Clomifene
Dienestrol
Hesperetin
Zinc
Genistein
Naringenin
Quercetin
4'-Hydroxyflavanone
Afimoxifene
Estriol
Phenolphthalein
Norethynodrel
Dioxybenzone
Zeranol
Gestrinone
Equol
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Estriol tripropionate
Diseases
GWAS
A body shape index (
34021172
)
Androgen levels (
22936694
)
Body size at age 10 (
32376654
)
Brain morphology (MOSTest) (
32665545
)
Estradiol levels (
34255042
)
Glycated hemoglobin levels (
34059833
)
Heel bone mineral density (
30598549
)
Hormone measurements (
24049095
)
Medication use (calcium channel blockers) (
31015401
)
Protein quantitative trait loci (
18464913
)
Red cell distribution width (
27863252
)
Refractive error (
32231278
)
Sex hormone levels (
26014426
)
Sex hormone-binding globulin levels (
22675492
22829776
)
Testosterone levels (
21998597
)
Uterine fibroids (
31649266
)
Waist circumference adjusted for body mass index (
34021172
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
21 interacting genes:
ADAMTS4
ARF6
ASS1
BARD1
DHODH
ECT2
EOLA1
HMGB1
JMJD1C
LAMTOR5
MCPH1
PAXIP1
PPDPF
PRKD1
RCHY1
RIN3
SHBG
SPINK7
TNS2
USP25
USP40
62 interacting genes:
A2M
ACP3
ACTA2
ACTB
ACTG2
AK2
AKR1B1
AP1B1
AP2A1
APEH
APOBEC3C
APOD
ASB16-AS1
ATP5F1A
AZGP1
CD177
CEP192
CLDN4
CLEC4G
COL1A2
CTSD
DDX3Y
DES
DSTN
EEF1A1
EIF3E
EIF3F
FLNA
FLOT1
FYTTD1
GRB2
HDHD5
HYI
JMJD7-PLA2G4B
KLK4
MPDU1
MT1F
MT1G
MT2A
MXD4
NOMO1
PACSIN2
PKM
PLA2G4A
PLP2
PSTPIP1
PSTPIP2
PTGDS
RMND5B
SEMA3F
SLC37A1
SLC37A4
SNAPIN
SNRNP70
SORD
SPMIP6
SRF
SRI
TINAGL1
UBE2O
UBE3A
ZC3H12A
Entrez ID
4502
6462
HPRD ID
08863
01646
Ensembl ID
ENSG00000125148
ENSG00000129214
Uniprot IDs
P02795
B0FWH2
B0FWH8
I3L145
P04278
PDB IDs
1MHU
2MHU
1D2S
1F5F
1KDK
1KDM
1LHN
1LHO
1LHU
1LHV
1LHW
6PYA
6PYB
6PYF
6ULB
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Endocytosis
Positive Regulation Of Mitotic Cytokinetic Process
Positive Regulation Of Mitotic Cytokinesis
Regulation Of Mitotic Cytokinesis
Negative Regulation Of Transport
Regulation Of Cellular Component Size
Positive Regulation Of Protein Localization To Nucleus
Liver Development
Regulation Of Establishment Of Protein Localization
Regulation Of Cellular Localization
Cellular Response To Stress
Regulation Of Nucleocytoplasmic Transport
Regulation Of Protein Localization
Erythrocyte Apoptotic Process
Positive Regulation Of Establishment Of Protein Localization
Regulation Of Endocytosis
Negative Regulation Of Receptor-mediated Endocytosis
Argininosuccinate Synthase Activity
Argininosuccinate Metabolic Process
Regulation Of Intracellular Protein Transport
Regulation Of Protein Export From Nucleus
Response To Ionizing Radiation
Negative Regulation Of MRNA 3'-end Processing
Dihydroorotate Dehydrogenase Activity
Dihydroorotate Dehydrogenase (quinone) Activity
Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Positive Regulation Of Protein Import Into Nucleus
Regulation Of Protein Localization To Nucleus
Calcium-dependent Protein Kinase Regulator Activity
Regulation Of Restriction Endodeoxyribonuclease Activity
Positive Regulation Of Myeloid Progenitor Cell Differentiation
Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril
Negative Regulation Of Mast Cell Chemotaxis
Extracellular Exosome
Protease Binding
Cell-cell Junction
Fructose Biosynthetic Process
Detoxification Of Copper Ion
Extracellular Space
Glucose 6-phosphate:phosphate Antiporter Activity
Cellular Response To Cadmium Ion
Lamellipodium
Cellular Response To Zinc Ion
Cellular Response To Copper Ion
Mesenchyme Migration
Glucose-6-phosphate Transport
Negative Regulation Of Cardiac Muscle Contraction
Intracellular Zinc Ion Homeostasis
Prostaglandin Metabolic Process
Prostanoid Metabolic Process
Response To Copper Ion
Rough Endoplasmic Reticulum
Hexose Metabolic Process
Regulation Of Chaperone-mediated Autophagy
Negative Regulation Of Striated Muscle Contraction
Response To Cadmium Ion
Cell-cell Junction Organization
Caveola Assembly
Carbohydrate Metabolic Process
Monosaccharide Metabolic Process
Plasma Membrane Raft Assembly
Response To Zinc Ion
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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