MT2A and ASS1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		MT2A	ASS1
Name		metallothionein 2A	argininosuccinate synthase 1
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Neuronal Cell Body Perikaryon Extracellular Exosome Cell Body Fiber
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding RNA Binding Argininosuccinate Synthase Activity Protein Binding ATP Binding Toxic Substance Binding Amino Acid Binding Ligase Activity Identical Protein Binding
	Biological Process	Intracellular Copper Ion Homeostasis Intracellular Zinc Ion Homeostasis Detoxification Of Copper Ion Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion	Urea Cycle Citrulline Metabolic Process Argininosuccinate Metabolic Process Kidney Development Liver Development L-arginine Biosynthetic Process Aspartate Metabolic Process Acute-phase Response Midgut Development Response To Nutrient Circadian Rhythm Amino Acid Biosynthetic Process Response To Xenobiotic Stimulus Response To Toxic Substance Response To Zinc Ion Response To Mycotoxin Response To Amine Response To Estradiol Response To Lipopolysaccharide Response To Amino Acid Response To Peptide Hormone Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Steroid Hormone Response To Glucocorticoid Response To Growth Hormone Diaphragm Development Response To Fatty Acid Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Ammonium Ion Cellular Response To CAMP Cellular Response To Type II Interferon Cellular Response To Tumor Necrosis Factor Cellular Response To Glucagon Stimulus Cellular Response To Oleic Acid Cellular Response To Amine Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Dexamethasone Stimulus Negative Regulation Of Leukocyte Cell-cell Adhesion
Pathways		Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling	Urea cycle
Drugs		Zinc Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Arginine Aspartic acid Aspartic acid Citrulline Citrulline ATP
Diseases		None	Citrullinemia (CTLN)
GWAS		No GWAS studies recorded	Femur bone mineral density x serum urate levels interaction ( 34046847 )
Interacting Genes		21 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PPDPF PRKD1 RCHY1 RIN3 SHBG SPINK7 TNS2 USP25 USP40	15 interacting genes: AKTIP APP ARAF ASCC2 ELN JAK2 LINC01554 MLH1 MT2A PTPN1 SLC13A1 SUMO2 TERF1 TERF2 USP4
Entrez ID		4502	445
HPRD ID		08863	04590
Ensembl ID		ENSG00000125148	ENSG00000130707
Uniprot IDs		P02795	P00966 Q5T6L4
PDB IDs		1MHU 2MHU	2NZ2
GO Terms Enriched among Interactors		Negative Regulation Of Endocytosis Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Negative Regulation Of Transport Regulation Of Cellular Component Size Positive Regulation Of Protein Localization To Nucleus Liver Development Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Cellular Response To Stress Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Localization Erythrocyte Apoptotic Process Positive Regulation Of Establishment Of Protein Localization Regulation Of Endocytosis Negative Regulation Of Receptor-mediated Endocytosis Argininosuccinate Synthase Activity Argininosuccinate Metabolic Process Regulation Of Intracellular Protein Transport Regulation Of Protein Export From Nucleus Response To Ionizing Radiation Negative Regulation Of MRNA 3'-end Processing Dihydroorotate Dehydrogenase Activity Dihydroorotate Dehydrogenase (quinone) Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Negative Regulation Of Mast Cell Chemotaxis	Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Endosome Lumen Negative Regulation Of Mitotic Recombination Cellular Response To Interleukin-3 Regulation Of Mitotic Recombination Telomerase Activity Shelterin Complex Signaling Receptor Activator Activity Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Acetylcholine Receptor Binding Postsynapse Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Protein Metabolic Process Intracellular Copper Ion Homeostasis Regulation Of Establishment Of Protein Localization Copper Ion Homeostasis Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Phosphorus Metabolic Process Insulin Receptor Binding Cellular Response To Copper Ion Positive Regulation Of Phosphate Metabolic Process Growth Hormone Receptor Signaling Pathway RNA-templated DNA Biosynthetic Process Negative Regulation Of DNA Metabolic Process Ephrin Receptor Binding Telomeric DNA Binding Positive Regulation Of Macromolecule Metabolic Process Microglial Cell Activation Regulation Of Protein Modification Process Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Amyloid-beta Complex Positive Regulation Of Metabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Copper Ion Enzyme Binding Regulation Of Response To Calcium Ion Response To Nerve Growth Factor Cell Activation Involved In Immune Response