MT2A and DHODH

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		MT2A	DHODH
Description		metallothionein 2A	dihydroorotate dehydrogenase (quinone)
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	Dihydroorotase Activity Dihydroorotate Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Dihydroorotate Dehydrogenase (quinone) Activity
	Biological Process	Intracellular Copper Ion Homeostasis Intracellular Zinc Ion Homeostasis Detoxification Of Copper Ion Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion	'de Novo' Pyrimidine Nucleobase Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process UDP Biosynthetic Process Pyrimidine Ribonucleotide Biosynthetic Process 'de Novo' UMP Biosynthetic Process
Pathways		Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling	Pyrimidine biosynthesis
Drugs		Zinc Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Leflunomide Atovaquone Orotic acid Capric dimethyl amine oxide Flavin mononucleotide Brequinar Analog Brequinar Dodecyldimethylamine N-oxide 2-[4-(4-Chlorophenyl)Cyclohexylidene]-3,4-Dihydroxy-1(2h)-Naphthalenone 5-Carbamoyl-1,1':4',1''-terphenyl-3-carboxylic acid SC12267 Manitimus (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamide (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide (2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide UNDECYLAMINE-N,N-DIMETHYL-N-OXIDE 2-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACID 3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACID 3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACID 2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACID N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide 3,6,9,12,15-PENTAOXATRICOSAN-1-OL Teriflunomide
Diseases
GWAS			Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Bone mineral density (hip) ( 30172743) Fibrinogen levels ( 28107422) Hand grip strength ( 29691431) LDL cholesterol levels in HIV infection ( 33109212) Low density lipoprotein cholesterol levels ( 29403010) Morning person ( 30696823) Number of sexual partners ( 30643258) Total cholesterol levels ( 29403010 33339817)
Interacting Genes		21 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PPDPF PRKD1 RCHY1 RIN3 SHBG SPINK7 TNS2 USP25 USP40	4 interacting genes: MT2A RNF19B TMED10 TTPA
Entrez ID		4502	1723
HPRD ID		08863	00521
Ensembl ID		ENSG00000125148	ENSG00000102967
Uniprot IDs		P02795	Q02127
PDB IDs		1MHU 2MHU	1D3G 1D3H 2B0M 2BXV 2FPT 2FPV 2FPY 2FQI 2PRH 2PRL 2PRM 2WV8 3F1Q 3FJ6 3FJL 3G0U 3G0X 3KVJ 3KVK 3KVL 3KVM 3U2O 3W7R 3ZWS 3ZWT 4IGH 4JGD 4JS3 4JTS 4JTT 4JTU 4LS0 4LS1 4LS2 4OQV 4RK8 4RKA 4RLI 4RR4 4YLW 4ZL1 4ZMG 5H2Z 5H73 5HIN 5HQE 5K9C 5K9D 5MUT 5MVC 5MVD 5TCE 5ZF4 5ZF7 5ZF8 5ZF9 5ZFA 5ZFB 6CJF 6CJG 6ET4 6FMD 6GK0 6IDJ 6J3B 6J3C 6JMD 6JME 6LP6 6LP7 6LP8 6LZL 6M2B 6OC0 6OC1 6QU7 6SYP 6VND 7K2U 7Z6C 8DHF 8DHG 8DHH 8K4F 8RAK 8VHL 8VHM 8YHR 9BKM 9BKN 9BKO 9DHG 9DHH 9DHI 9DHJ 9I2Y
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endocytosis Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Mitotic Cytokinesis Regulation Of Mitotic Cytokinesis Negative Regulation Of Transport Regulation Of Cellular Component Size Positive Regulation Of Protein Localization To Nucleus Liver Development Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Cellular Response To Stress Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Localization Erythrocyte Apoptotic Process Positive Regulation Of Establishment Of Protein Localization Regulation Of Endocytosis Negative Regulation Of Receptor-mediated Endocytosis Argininosuccinate Synthase Activity Argininosuccinate Metabolic Process Regulation Of Intracellular Protein Transport Regulation Of Protein Export From Nucleus Response To Ionizing Radiation Negative Regulation Of MRNA 3'-end Processing Dihydroorotate Dehydrogenase Activity Dihydroorotate Dehydrogenase (quinone) Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization To Nucleus Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Regulation Of Skeletal Muscle Contraction By Modulation Of Calcium Ion Sensitivity Of Myofibril Negative Regulation Of Mast Cell Chemotaxis	Negative Regulation Of Establishment Of Blood-brain Barrier Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Cellular Response To Erythropoietin Cellular Response To Interleukin-3 Response To Erythropoietin Vitamin E Metabolic Process Regulation Of Establishment Of Blood-brain Barrier Vitamin E Binding Gamma-secretase Complex COPI Coating Of Golgi Vesicle Vesicle Targeting, To, From Or Within Golgi Positive Regulation Of Amyloid-beta Clearance Detoxification Of Copper Ion Phosphatidylinositol Bisphosphate Binding Lipid Transfer Activity Cytolytic Granule COPI-coated Vesicle Intracellular Copper Ion Homeostasis Trans-Golgi Network Transport Vesicle Zymogen Granule Membrane Vesicle Targeting Copper Ion Homeostasis Cellular Response To Cadmium Ion Regulation Of Amyloid-beta Clearance Cellular Response To Zinc Ion Cellular Response To Copper Ion COPII Vesicle Coating Phosphatidylinositol-3,4-bisphosphate Binding Embryonic Placenta Development Protein Transmembrane Transporter Activity Protein Localization To Golgi Apparatus Intracellular Zinc Ion Homeostasis Vesicle Cargo Loading Response To Copper Ion Membrane Organization Intermembrane Lipid Transfer Vesicle Budding From Membrane Vesicle Coating Ubiquitin Conjugating Enzyme Binding COPII-coated ER To Golgi Transport Vesicle Response To Cadmium Ion Natural Killer Cell Mediated Cytotoxicity Placenta Development Vitamin Transport Regulation Of Amyloid-beta Formation Natural Killer Cell Mediated Immunity Response To Zinc Ion Cis-Golgi Network
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