KPRP and PPIL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KPRP	PPIL1
Description		keratinocyte proline rich protein	peptidylprolyl isomerase like 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Isomerase Activity Disordered Domain Specific Binding
	Biological Process	Desmosome Organization Inflammatory Response Epidermis Development Skin Development Establishment Of Skin Barrier	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization MRNA Processing Protein Folding RNA Splicing Embryonic Brain Development
Pathways		Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Asthma ( 31619474) Psoriasis ( 25854761)	Acne (severe) ( 24927181) Blood protein levels ( 30072576) Heart rate ( 28610988) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate variability traits (pvRSA/HF) ( 28613276) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Resting heart rate ( 27798624) Weight ( 28552196)
Interacting Genes		110 interacting genes: ACTMAP AKAP8L ANKS1A ATG9A BTC CATSPER1 CCDC57 CES1 CKS1B CLCNKA CNFN CNNM3 COL8A1 CREB5 CYSRT1 DARS1-AS1 DMRT3 DYRK1A EIF3E ESR2 FAM221B FAM72B FBXO17 FCHO1 FHL2 FHL3 FRS3 GNE GRAP2 GRB2 GUCD1 HCK HEXIM2 HNRNPF HOXA1 HOXC8 HSD3B7 ITGB4 ITIH6 KRTAP1-3 KRTAP1-5 KRTAP10-8 KRTAP12-3 KRTAP13-2 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP3-2 KRTAP4-2 KRTAP4-5 KRTAP5-3 KRTAP5-7 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-3 LCE3A LCE3C LCE3D LCE3E LIMS1 LMO2 LNX1 MAPKBP1 MEOX2 MGAT5B MIIP MLH1 NBPF19 NCK2 NID2 NOTCH2NLA NPBWR2 NR4A3 NTN4 NUFIP2 OTX1 PDGFRB PHLDA1 PLA2G10 PLSCR4 POU4F2 PPIL1 RANBP3 RBP3 RGL2 RNF38 SAXO4 SEMA3B SH3KBP1 SLC15A2 SPRED2 SPRY1 SPRY3 STK16 TEKT4 TFAP2D TNS2 TRIM42 TRIP6 UBASH3A UBASH3B VGLL3 VWC2 ZNF587	25 interacting genes: COL17A1 CPSF6 DDIT4L GADD45G HNRNPA1 HNRNPUL1 KPRP LHX2 LNX2 N4BP2L2 POU6F2 PPP1R8 PRR22 PRR35 RBM42 RIMBP3 SF3B3 SNW1 SPDYE4 SRPK1 SRPK2 TCF4 THOC5 UFL1 WDR77
Entrez ID		448834	51645
HPRD ID		18838	03194
Ensembl ID		ENSG00000203786	ENSG00000137168
Uniprot IDs		Q5T749	Q9Y3C6
PDB IDs			1XWN 2K7N 2X7K 5MQF 5XJC 5YZG 5Z56 5Z57 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		Intermediate Filament Protein Binding Keratin Filament Keratinization	MRNA Processing RNA Splicing Regulation Of RNA Splicing MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing RNA Processing Spliceosomal Complex Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Spliceosomal Complex Assembly Nucleic Acid Metabolic Process RNA Binding Protein-RNA Complex Assembly Catalytic Step 2 Spliceosome Nuclear Speck Nucleobase-containing Compound Metabolic Process Nucleus MRNA Binding Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Viral Genome Replication Cell Differentiation Ribonuclease E Activity Exon-exon Junction Complex Binding UFM1 Ligase Activity Oocyte Axis Specification Regulation Of RNA Metabolic Process Protein-containing Complex Assembly Positive Regulation Of RNA Splicing Negative Regulation Of Viral Genome Replication
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