SLC13A1 and ACOT2

Number of citations of the paper that reports this interaction (PubMedID 18407958)
55

Data Source:
BioGRID (protein complementation assay)

		SLC13A1	ACOT2
Description		solute carrier family 13 member 1	acyl-CoA thioesterase 2
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GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane	Mitochondrion Mitochondrial Matrix Peroxisomal Matrix Cytosol
	Molecular Function	Secondary Active Sulfate Transmembrane Transporter Activity Symporter Activity Solute:sodium Symporter Activity Monoatomic Anion:sodium Symporter Activity Sodium:sulfate Symporter Activity Transmembrane Transporter Activity	Protein Binding Hydrolase Activity Thiolester Hydrolase Activity Fatty Acyl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Sodium Ion Transmembrane Transport Transmembrane Transport Monoatomic Anion Transmembrane Transport Sulfate Transmembrane Transport	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Monocarboxylic Acid Metabolic Process
Pathways		Sodium-coupled sulphate, di- and tri-carboxylate transporters	Mitochondrial Fatty Acid Beta-Oxidation Peroxisomal protein import Peroxisomal protein import Mitochondrial protein degradation
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) High density lipoprotein cholesterol levels ( 30498476) Systolic blood pressure ( 30578418)	Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		31 interacting genes: ACOT2 ACTR10 APLP2 ARL6IP1 ASS1 CD59 COQ5 COQ9 CRYAB DYNLL1 FTL GRN HSPA1A MKRN1 NDUFS5 NHERF1 NHERF2 OGDHL PDZK1 PNPLA6 PRSS8 RHOA SDHD SEC61A1 SELPLG SERPINA1 TBRG1 TM4SF1 TMED10 TP53I11 TSPAN3	2 interacting genes: PEX5 SLC13A1
Entrez ID		6561	10965
HPRD ID		08394	10173
Ensembl ID		ENSG00000081800	ENSG00000119673
Uniprot IDs		A4D0X1 Q2NKK0 Q9BZW2	B3KSA0 P49753
PDB IDs		8W6H 8W6N 8W6O 8W6T 8Y5U 8Y5W 8Y5X 8Y5Y 8Y5Z	3HLK
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Vesicle Protein-membrane Adaptor Activity Sec61 Translocon Complex Ubiquinone Biosynthesis Complex Establishment Of Epithelial Cell Apical/basal Polarity Mitochondrion Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cellular Localization ATP Metabolic Process Aerobic Electron Transport Chain Cotranslational Protein Targeting To Membrane Ubiquinone Metabolic Process Ubiquinone Biosynthetic Process Azurophil Granule Lumen Quinone Metabolic Process Establishment Of Apical/basal Cell Polarity Signaling Receptor Binding Aerobic Respiration Respiratory Electron Transport Chain Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Protein Stabilization Electron Transport Chain Cellular Respiration Membrane Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Establishment Of Epithelial Cell Polarity Mitotic Cleavage Furrow Formation Argininosuccinate Synthase Activity Argininosuccinate Metabolic Process Regulation Of Transport Protein Refolding Positive Regulation Of Aspartic-type Peptidase Activity Purine Ribonucleotide Metabolic Process Purine-containing Compound Metabolic Process Ficolin-1-rich Granule Lumen COP9 Signalosome Microvillus Membrane Tricarboxylic Acid Cycle Renal Phosphate Ion Absorption Protein Transmembrane Transporter Activity Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Pronephric Nephron Development Isoprenoid Binding	Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Protein Import Into Peroxisome Matrix, Translocation Peroxisome Targeting Sequence Binding Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Secondary Active Sulfate Transmembrane Transporter Activity Protein Unfolding Protein Import Into Peroxisome Matrix Pexophagy Sulfate Transmembrane Transport Solute:sodium Symporter Activity INTAC Complex Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Integrator Complex RNA Polymerase II Transcription Initiation Surveillance Cerebral Cortex Neuron Differentiation Peroxisome Organization Receptor Recycling Intracellular Protein Transmembrane Transport Cerebral Cortex Cell Migration Positive Regulation Of Multicellular Organism Growth SnRNA Processing Very Long-chain Fatty Acid Metabolic Process Nuclear RNA Surveillance Forebrain Neuron Differentiation RNA Surveillance Telencephalon Cell Migration Forebrain Cell Migration Receptor Metabolic Process Peroxisomal Matrix SnRNA Metabolic Process Fatty Acid Beta-oxidation Protein Monoubiquitination Endoplasmic Reticulum Organization Peroxisomal Membrane
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