SLC13A1 and PRSS8

Number of citations: 55 (PubMedID 18407958)
Data Source: BioGRID (protein complementation assay)

		SLC13A1	PRSS8
Name		solute carrier family 13 member 1	serine protease 8
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Secondary Active Sulfate Transmembrane Transporter Activity Symporter Activity Solute:sodium Symporter Activity Monoatomic Anion:sodium Symporter Activity Sodium:sulfate Symporter Activity Transmembrane Transporter Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Sodium Ion Transmembrane Transport Transmembrane Transport Monoatomic Anion Transmembrane Transport Sulfate Transmembrane Transport	Proteolysis Positive Regulation Of Sodium Ion Transport
Pathways		Sodium-coupled sulphate, di- and tri-carboxylate transporters	Formation of the cornified envelope
Drugs		None	1-[4-(hydroxymethyl)phenyl]guanidine
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065 ) High density lipoprotein cholesterol levels ( 30498476 ) Systolic blood pressure ( 30578418 )	Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 )
Novel Interactors		None recorded	1 novel interactors: HNRNPLL
Interacting Genes		31 interacting genes: ACOT2 ACTR10 APLP2 ARL6IP1 ASS1 CD59 COQ5 COQ9 CRYAB DYNLL1 FTL GRN HSPA1A MKRN1 NDUFS5 NHERF1 NHERF2 OGDHL PDZK1 PNPLA6 PRSS8 RHOA SDHD SEC61A1 SELPLG SERPINA1 TBRG1 TM4SF1 TMED10 TP53I11 TSPAN3	2 interacting genes: ATF7IP SLC13A1
Entrez ID		6561	5652
HPRD ID		08394	02895
Ensembl ID		ENSG00000081800	ENSG00000052344
Uniprot IDs		A4D0X1 Q2NKK0 Q9BZW2	Q16651
PDB IDs		8W6H 8W6N 8W6O 8W6T 8Y5U 8Y5W 8Y5X 8Y5Y 8Y5Z	3DFJ 3DFL 3E0N 3E0P 3E16 3E1X 3FVF 3GYL 3GYM
GO Terms Enriched among Interactors		Extracellular Exosome Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Vesicle Protein-membrane Adaptor Activity Sec61 Translocon Complex Ubiquinone Biosynthesis Complex Establishment Of Epithelial Cell Apical/basal Polarity Mitochondrion Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cellular Localization ATP Metabolic Process Aerobic Electron Transport Chain Cotranslational Protein Targeting To Membrane Ubiquinone Metabolic Process Ubiquinone Biosynthetic Process Azurophil Granule Lumen Quinone Metabolic Process Establishment Of Apical/basal Cell Polarity Signaling Receptor Binding Aerobic Respiration Respiratory Electron Transport Chain Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Protein Stabilization Electron Transport Chain Cellular Respiration Membrane Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Establishment Of Epithelial Cell Polarity Mitotic Cleavage Furrow Formation Argininosuccinate Synthase Activity Argininosuccinate Metabolic Process Regulation Of Transport Protein Refolding Positive Regulation Of Aspartic-type Peptidase Activity Purine Ribonucleotide Metabolic Process Purine-containing Compound Metabolic Process Ficolin-1-rich Granule Lumen COP9 Signalosome Microvillus Membrane Tricarboxylic Acid Cycle Renal Phosphate Ion Absorption Protein Transmembrane Transporter Activity Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Pronephric Nephron Development Isoprenoid Binding	Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Secondary Active Sulfate Transmembrane Transporter Activity