SLC13A1 and SDHD

Number of citations of the paper that reports this interaction (PubMedID 18407958)
55

Data Source:
BioGRID (protein complementation assay)

		SLC13A1	SDHD
Description		solute carrier family 13 member 1	succinate dehydrogenase complex subunit D
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane	Mitochondrion Mitochondrial Envelope Mitochondrial Inner Membrane Membrane Respiratory Chain Complex II (succinate Dehydrogenase)
	Molecular Function	Secondary Active Sulfate Transmembrane Transporter Activity Symporter Activity Solute:sodium Symporter Activity Monoatomic Anion:sodium Symporter Activity Sodium:sulfate Symporter Activity Transmembrane Transporter Activity	Protein Binding Succinate Dehydrogenase (quinone) Activity Electron Transfer Activity Heme Binding Metal Ion Binding Ubiquinone Binding
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Sodium Ion Transmembrane Transport Transmembrane Transport Monoatomic Anion Transmembrane Transport Sulfate Transmembrane Transport	Tricarboxylic Acid Cycle Mitochondrial Electron Transport, Succinate To Ubiquinone Proton Motive Force-driven Mitochondrial ATP Synthesis Regulation Of Catecholamine Secretion Cellular Response To Hypoxia
Pathways		Sodium-coupled sulphate, di- and tri-carboxylate transporters	Respiratory electron transport Citric acid cycle (TCA cycle) Maturation of TCA enzymes and regulation of TCA cycle
Drugs			Hexachlorophene 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol Ubiquinone Q1
Diseases			Carcinoid
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) High density lipoprotein cholesterol levels ( 30498476) Systolic blood pressure ( 30578418)	Brain morphology (MOSTest) ( 32665545) General risk tolerance (MTAG) ( 30643258) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		31 interacting genes: ACOT2 ACTR10 APLP2 ARL6IP1 ASS1 CD59 COQ5 COQ9 CRYAB DYNLL1 FTL GRN HSPA1A MKRN1 NDUFS5 NHERF1 NHERF2 OGDHL PDZK1 PNPLA6 PRSS8 RHOA SDHD SEC61A1 SELPLG SERPINA1 TBRG1 TM4SF1 TMED10 TP53I11 TSPAN3	5 interacting genes: F2RL1 GPR35 MTNR1B RHBDD2 SLC13A1
Entrez ID		6561	6392
HPRD ID		08394	04069
Ensembl ID		ENSG00000081800	ENSG00000204370
Uniprot IDs		A4D0X1 Q2NKK0 Q9BZW2	A0A0S2Z4H7 A0A0S2Z4J3 O14521
PDB IDs		8W6H 8W6N 8W6O 8W6T 8Y5U 8Y5W 8Y5X 8Y5Y 8Y5Z	8GS8
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Vesicle Protein-membrane Adaptor Activity Sec61 Translocon Complex Ubiquinone Biosynthesis Complex Establishment Of Epithelial Cell Apical/basal Polarity Mitochondrion Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cellular Localization ATP Metabolic Process Aerobic Electron Transport Chain Cotranslational Protein Targeting To Membrane Ubiquinone Metabolic Process Ubiquinone Biosynthetic Process Azurophil Granule Lumen Quinone Metabolic Process Establishment Of Apical/basal Cell Polarity Signaling Receptor Binding Aerobic Respiration Respiratory Electron Transport Chain Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Protein Stabilization Electron Transport Chain Cellular Respiration Membrane Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Establishment Of Epithelial Cell Polarity Mitotic Cleavage Furrow Formation Argininosuccinate Synthase Activity Argininosuccinate Metabolic Process Regulation Of Transport Protein Refolding Positive Regulation Of Aspartic-type Peptidase Activity Purine Ribonucleotide Metabolic Process Purine-containing Compound Metabolic Process Ficolin-1-rich Granule Lumen COP9 Signalosome Microvillus Membrane Tricarboxylic Acid Cycle Renal Phosphate Ion Absorption Protein Transmembrane Transporter Activity Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Pronephric Nephron Development Isoprenoid Binding	Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion G Protein-coupled Receptor Activity Negative Regulation Of Protein Secretion Negative Regulation Of Hormone Secretion Negative Regulation Of Transport Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Proteinase-activated Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Negative Regulation Of Secretion By Cell Positive Regulation Of Glomerular Filtration G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Transport Regulation Of Renin Secretion Into Blood Stream Regulation Of Tube Size Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Establishment Of Protein Localization Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Regulation Of Insulin Secretion Negative Regulation Of Secretion Positive Regulation Of Killing Of Cells Of Another Organism Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Peptide Hormone Secretion Mature Conventional Dendritic Cell Differentiation Thrombin-activated Receptor Activity Regulation Of Neuronal Action Potential Negative Regulation Of Protein Localization Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Hormone Secretion Regulation Of Protein Secretion Vascular Process In Circulatory System C-X-C Chemokine Receptor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Secondary Active Sulfate Transmembrane Transporter Activity Signal Recognition Particle Binding Regulation Of Glomerular Filtration Thrombin-activated Receptor Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?