SLC13A1 and OGDHL

Number of citations of the paper that reports this interaction (PubMedID 18407958)
55

Data Source:
BioGRID (protein complementation assay)

		SLC13A1	OGDHL
Description		solute carrier family 13 member 1	oxoglutarate dehydrogenase L
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane	Mitochondrion Mitochondrial Matrix Oxoglutarate Dehydrogenase Complex
	Molecular Function	Secondary Active Sulfate Transmembrane Transporter Activity Symporter Activity Solute:sodium Symporter Activity Monoatomic Anion:sodium Symporter Activity Sodium:sulfate Symporter Activity Transmembrane Transporter Activity	Oxoglutarate Dehydrogenase (succinyl-transferring) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, Disulfide As Acceptor Thiamine Pyrophosphate Binding Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Sodium Ion Transmembrane Transport Transmembrane Transport Monoatomic Anion Transmembrane Transport Sulfate Transmembrane Transport	Glycolytic Process Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process
Pathways		Sodium-coupled sulphate, di- and tri-carboxylate transporters
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) High density lipoprotein cholesterol levels ( 30498476) Systolic blood pressure ( 30578418)
Interacting Genes		31 interacting genes: ACOT2 ACTR10 APLP2 ARL6IP1 ASS1 CD59 COQ5 COQ9 CRYAB DYNLL1 FTL GRN HSPA1A MKRN1 NDUFS5 NHERF1 NHERF2 OGDHL PDZK1 PNPLA6 PRSS8 RHOA SDHD SEC61A1 SELPLG SERPINA1 TBRG1 TM4SF1 TMED10 TP53I11 TSPAN3	5 interacting genes: CDK4 CSNK2A1 SLC13A1 SMYD1 STAT3
Entrez ID		6561	55753
HPRD ID		08394	07704
Ensembl ID		ENSG00000081800	ENSG00000197444
Uniprot IDs		A4D0X1 Q2NKK0 Q9BZW2	Q9ULD0
PDB IDs		8W6H 8W6N 8W6O 8W6T 8Y5U 8Y5W 8Y5X 8Y5Y 8Y5Z
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Vesicle Protein-membrane Adaptor Activity Sec61 Translocon Complex Ubiquinone Biosynthesis Complex Establishment Of Epithelial Cell Apical/basal Polarity Mitochondrion Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cellular Localization ATP Metabolic Process Aerobic Electron Transport Chain Cotranslational Protein Targeting To Membrane Ubiquinone Metabolic Process Ubiquinone Biosynthetic Process Azurophil Granule Lumen Quinone Metabolic Process Establishment Of Apical/basal Cell Polarity Signaling Receptor Binding Aerobic Respiration Respiratory Electron Transport Chain Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Protein Stabilization Electron Transport Chain Cellular Respiration Membrane Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Establishment Of Epithelial Cell Polarity Mitotic Cleavage Furrow Formation Argininosuccinate Synthase Activity Argininosuccinate Metabolic Process Regulation Of Transport Protein Refolding Positive Regulation Of Aspartic-type Peptidase Activity Purine Ribonucleotide Metabolic Process Purine-containing Compound Metabolic Process Ficolin-1-rich Granule Lumen COP9 Signalosome Microvillus Membrane Tricarboxylic Acid Cycle Renal Phosphate Ion Absorption Protein Transmembrane Transporter Activity Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Pronephric Nephron Development Isoprenoid Binding	Transcription Regulator Complex Regulation Of Epithelial Cell Proliferation Cyclin D2-CDK4 Complex Cellular Response To Ether Positive Regulation Of Cell Population Proliferation Protein Serine Kinase Activity Regulation Of Type B Pancreatic Cell Proliferation Cyclin D1-CDK4 Complex Response To Phorbol 13-acetate 12-myristate Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To Ionomycin Cyclin D3-CDK4 Complex Regulation Of Cell Cycle Response To Alcohol Aggrephagy Double-strand Break Repair Via Classical Nonhomologous End Joining Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Aggrephagy Establishment Of Protein Localization To Organelle Negative Regulation Of Catabolic Process Regulation Of Autophagy Sulfate Transmembrane Transport Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Secondary Active Sulfate Transmembrane Transporter Activity Solute:sodium Symporter Activity Regulation Of Hydrogen Peroxide Metabolic Process Interleukin-10-mediated Signaling Pathway RNA Sequestering Activity Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of MiRNA Processing Negative Regulation Of Primary MiRNA Processing Cellular Response To Leptin Stimulus Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Inflammatory Response To Wounding Inflammatory Response To Wounding Interleukin-2-mediated Signaling Pathway Negative Regulation Of Hydrogen Peroxide Metabolic Process Nuclear Glucocorticoid Receptor Binding Postsynapse To Nucleus Signaling Pathway Regulation Of Skeletal Muscle Satellite Cell Proliferation Interleukin-9-mediated Signaling Pathway Negative Regulation Of Neuron Migration Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Interleukin-11-mediated Signaling Pathway Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Hydrogen Peroxide Biosynthetic Process
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