SLC13A1 and SEC61A1

Number of citations of the paper that reports this interaction (PubMedID 18407958)
55

Data Source:
BioGRID (protein complementation assay)

		SLC13A1	SEC61A1
Description		solute carrier family 13 member 1	SEC61 translocon subunit alpha 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Secondary Active Sulfate Transmembrane Transporter Activity Symporter Activity Solute:sodium Symporter Activity Monoatomic Anion:sodium Symporter Activity Sodium:sulfate Symporter Activity Transmembrane Transporter Activity	Signal Sequence Binding Calcium Channel Activity Protein Binding Protein Transmembrane Transporter Activity Ribosome Binding
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Sodium Ion Transmembrane Transport Transmembrane Transport Monoatomic Anion Transmembrane Transport Sulfate Transmembrane Transport	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Endoplasmic Reticulum Organization Protein Transport Post-translational Protein Targeting To Membrane, Translocation Response To Type II Interferon Pronephric Nephron Development Protein Targeting To ER Protein Insertion Into ER Membrane Calcium Ion Transmembrane Transport
Pathways		Sodium-coupled sulphate, di- and tri-carboxylate transporters	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) High density lipoprotein cholesterol levels ( 30498476) Systolic blood pressure ( 30578418)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		31 interacting genes: ACOT2 ACTR10 APLP2 ARL6IP1 ASS1 CD59 COQ5 COQ9 CRYAB DYNLL1 FTL GRN HSPA1A MKRN1 NDUFS5 NHERF1 NHERF2 OGDHL PDZK1 PNPLA6 PRSS8 RHOA SDHD SEC61A1 SELPLG SERPINA1 TBRG1 TM4SF1 TMED10 TP53I11 TSPAN3	10 interacting genes: BAG6 CALM1 GET3 HSPA5 MLH1 PTEN SEC61G SERP1 SLC13A1 TNF
Entrez ID		6561	29927
HPRD ID		08394	15316
Ensembl ID		ENSG00000081800	ENSG00000058262
Uniprot IDs		A4D0X1 Q2NKK0 Q9BZW2	B3KME8 B3KNF6 B4DR61 C9JXC6 P61619
PDB IDs		8W6H 8W6N 8W6O 8W6T 8Y5U 8Y5W 8Y5X 8Y5Y 8Y5Z	6W6L 8B6L 8DNV 8DNW 8DNX 8DNY 8DNZ 8DO0 8DO1 8DO2 8DO3
Enriched GO Terms of Interacting Partners?		Extracellular Exosome Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Vesicle Protein-membrane Adaptor Activity Sec61 Translocon Complex Ubiquinone Biosynthesis Complex Establishment Of Epithelial Cell Apical/basal Polarity Mitochondrion Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Cellular Localization ATP Metabolic Process Aerobic Electron Transport Chain Cotranslational Protein Targeting To Membrane Ubiquinone Metabolic Process Ubiquinone Biosynthetic Process Azurophil Granule Lumen Quinone Metabolic Process Establishment Of Apical/basal Cell Polarity Signaling Receptor Binding Aerobic Respiration Respiratory Electron Transport Chain Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Protein Stabilization Electron Transport Chain Cellular Respiration Membrane Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Establishment Of Epithelial Cell Polarity Mitotic Cleavage Furrow Formation Argininosuccinate Synthase Activity Argininosuccinate Metabolic Process Regulation Of Transport Protein Refolding Positive Regulation Of Aspartic-type Peptidase Activity Purine Ribonucleotide Metabolic Process Purine-containing Compound Metabolic Process Ficolin-1-rich Granule Lumen COP9 Signalosome Microvillus Membrane Tricarboxylic Acid Cycle Renal Phosphate Ion Absorption Protein Transmembrane Transporter Activity Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Pronephric Nephron Development Isoprenoid Binding	Post-translational Protein Targeting To Membrane, Translocation Ribosome Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Tail-anchored Membrane Protein Insertion Into ER Membrane Intracellular Signal Transduction Misfolded Protein Binding Ubiquitin-specific Protease Binding Positive Regulation Of Protein Metabolic Process Protein Insertion Into ER Membrane Intracellular Protein Transmembrane Transport Protein Targeting To ER Intrinsic Apoptotic Signaling Pathway Establishment Of Protein Localization To Endoplasmic Reticulum Protein Insertion Into Membrane Establishment Of Protein Localization Substantia Nigra Development Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Action Potential Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Type II Interferon Protein Transmembrane Transport Response To Endoplasmic Reticulum Stress Cerebellum Structural Organization Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Folding In Endoplasmic Reticulum Meiotic Spindle Midzone Assembly Positive Regulation Of Immunoglobulin Mediated Immune Response Meiotic Metaphase Chromosome Alignment Positive Regulation Of Immunoglobulin Production Chiasma Apoptotic Signaling Pathway Late Recombination Nodule Regulation Of Immunoglobulin Production Chromosome Organization Involved In Meiotic Cell Cycle Meiotic Metaphase I Homologous Chromosome Alignment Positive Regulation Of Proteolysis Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Wound Healing Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Negative Regulation Of Bile Acid Secretion
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