ASPH and GSC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ASPH	GSC2
Description		aspartate beta-hydroxylase	goosecoid homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex	Chromatin Nucleus
	Molecular Function	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity Oxidoreductase Activity Transmembrane Transporter Binding Metal Ion Binding Dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Detection Of Calcium Ion Muscle Contraction Pattern Specification Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Stability Activation Of Store-operated Calcium Channel Activity Response To ATP Limb Morphogenesis Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Roof Of Mouth Development Face Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Depolymerization	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis
Pathways		Stimuli-sensing channels Ion homeostasis Protein hydroxylation
Drugs		Aspartic acid
Diseases
GWAS		Blood protein levels ( 30072576) BRCA1/2-negative high-risk breast cancer ( 30323354) Resting heart rate ( 28270201) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Urate levels in overweight individuals ( 25811787)	Metabolite levels ( 22916037)
Interacting Genes		73 interacting genes: - AGR2 APP BGLAP CDSN CHRM5 CST1 CTSA CXorf66 DCD DEFB1 DHRSX ENPP6 FBXO7 FDCSP FGFBP1 FKBP7 GAL GAST GET3 GOLM1 GPR119 GPX7 GPX8 GSC2 GUCA2A IL21 INSL5 KCNIP1 KCNIP3 KCNIP4 LCN2 LINC00632 LRPAP1 LTA NUCB2 OCIAD1 OGT PCSK4 PDGFA PDGFRL PLAAT2 PLEKHF2 PRAP1 PRB1 PRB2 PRB4 PRH1 PTH PTN RCN1 RELL2 RNASEH1 SCGB1C2 SDC2 SF3A2 SGTB SHISAL1 SLC51B SMIM11 SMIM19 SOD3 SPINK1 TMEM167B TMX2 TNFRSF10B TRDN TUFM TXNDC15 UGT2B11 WFDC12 WFDC5 ZG16	60 interacting genes: ALPP ANXA5 ASPH BEST3 BNIP2 C19orf47 C1D CALM1 CALM2 CALM3 CALR CDKN2D CIAO2A COL8A1 CRCP CSNK2A1 DYRK1B EGLN3 EIF5A ETFDH FAM221B FKBP6 GALNT11 GCM2 GTF2H5 GTSF1L GUCA1A GUCY1A2 HMBOX1 ISX KDM6A KLHL38 KRT34 KRTAP5-9 LCE3E LTO1 MAD2L2 MAPK9 MARF1 MID2 MORF4L1 MRPL53 MRPS23 NME7 PACSIN2 PDE4C PRKAB2 PTER RNF4 SCAF1 SDCBP TIPIN TNPO2 TSR2 UBE2R2 VCX2 XRCC4 YPEL5 ZNF444 ZNF587
Entrez ID		444	2928
HPRD ID		08996	03506
Ensembl ID		ENSG00000198363	ENSG00000063515
Uniprot IDs		B4DQ07 B7ZM96 G3XAN5 Q12797	O15499
PDB IDs		5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6Q9F 6Q9I 6QA5 6RK9 6YYU 6YYV 6YYW 6YYX 6YYY 6Z6Q 6Z6R 7BMI 7BMJ 7E6J 7YB8 7YB9 7YBA 7YBB 7YBC 8RE5 8RE6 8RE7 8RE8 8RE9
Enriched GO Terms of Interacting Partners?		Extracellular Region Golgi Lumen Extracellular Space Endoplasmic Reticulum Lumen Hormone Activity Defense Response To Bacterium Response To Bacterium Endoplasmic Reticulum Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Regulation Of Metal Ion Transport Peptidase Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport	Regulation Of Cell Communication By Electrical Coupling Detection Of Calcium Ion Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Titin Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity DNA Metabolic Process Response To Metal Ion Protein Phosphatase Activator Activity Calyx Of Held Protein Binding Catalytic Complex Negative Regulation Of Transporter Activity Response To Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Striated Muscle Contraction DNA Damage Response Spindle Microtubule Negative Regulation Of Monoatomic Ion Transport Nucleic Acid Metabolic Process Presynaptic Endocytosis Substantia Nigra Development Sarcoplasmic Reticulum Lumen Calcium Channel Regulator Activity Detection Of Chemical Stimulus Sperm Midpiece Adenylate Cyclase Binding Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Nucleobase-containing Compound Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?