ASPH and WFDC12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ASPH	WFDC12
Description		aspartate beta-hydroxylase	WAP four-disulfide core domain 12
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex	Extracellular Region Extracellular Space
	Molecular Function	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity Oxidoreductase Activity Transmembrane Transporter Binding Metal Ion Binding Dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Detection Of Calcium Ion Muscle Contraction Pattern Specification Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Stability Activation Of Store-operated Calcium Channel Activity Response To ATP Limb Morphogenesis Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Roof Of Mouth Development Face Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Depolymerization	Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response
Pathways		Stimuli-sensing channels Ion homeostasis Protein hydroxylation
Drugs		Aspartic acid
Diseases
GWAS		Blood protein levels ( 30072576) BRCA1/2-negative high-risk breast cancer ( 30323354) Resting heart rate ( 28270201) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Urate levels in overweight individuals ( 25811787)	Bipolar disorder ( 31043756 34002096)
Interacting Genes		73 interacting genes: - AGR2 APP BGLAP CDSN CHRM5 CST1 CTSA CXorf66 DCD DEFB1 DHRSX ENPP6 FBXO7 FDCSP FGFBP1 FKBP7 GAL GAST GET3 GOLM1 GPR119 GPX7 GPX8 GSC2 GUCA2A IL21 INSL5 KCNIP1 KCNIP3 KCNIP4 LCN2 LINC00632 LRPAP1 LTA NUCB2 OCIAD1 OGT PCSK4 PDGFA PDGFRL PLAAT2 PLEKHF2 PRAP1 PRB1 PRB2 PRB4 PRH1 PTH PTN RCN1 RELL2 RNASEH1 SCGB1C2 SDC2 SF3A2 SGTB SHISAL1 SLC51B SMIM11 SMIM19 SOD3 SPINK1 TMEM167B TMX2 TNFRSF10B TRDN TUFM TXNDC15 UGT2B11 WFDC12 WFDC5 ZG16	6 interacting genes: ASPH SGTA SGTB SLC39A7 UBQLN1 UBQLN2
Entrez ID		444	128488
HPRD ID		08996	15674
Ensembl ID		ENSG00000198363	ENSG00000168703
Uniprot IDs		B4DQ07 B7ZM96 G3XAN5 Q12797	Q8WWY7
PDB IDs		5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6Q9F 6Q9I 6QA5 6RK9 6YYU 6YYV 6YYW 6YYX 6YYY 6Z6Q 6Z6R 7BMI 7BMJ 7E6J 7YB8 7YB9 7YBA 7YBB 7YBC 8RE5 8RE6 8RE7 8RE8 8RE9
Enriched GO Terms of Interacting Partners?		Extracellular Region Golgi Lumen Extracellular Space Endoplasmic Reticulum Lumen Hormone Activity Defense Response To Bacterium Response To Bacterium Endoplasmic Reticulum Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Regulation Of Metal Ion Transport Peptidase Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport	TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transport Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Muscle Contraction Regulation Of Transport Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Protein Catabolic Process Smooth Muscle Contraction Mature B Cell Apoptotic Process Negative Regulation Of Adenosine Receptor Signaling Pathway Muscle System Process 2'-deoxyadenosine Deaminase Activity Xanthine Biosynthetic Process Negative Regulation Of Penile Erection Regulation Of Monoatomic Cation Transmembrane Transport Response To Endoplasmic Reticulum Stress Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Germinal Center Formation Negative Regulation Of Mucus Secretion Mononuclear Cell Differentiation Inosine Biosynthetic Process Penile Erection Hypoxanthine Salvage DATP Catabolic Process Peptidyl-aspartic Acid 3-dioxygenase Activity Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Protein Targeting To Membrane Negative Regulation Of G Protein-coupled Receptor Internalization Esophagus Smooth Muscle Contraction Autophagosome Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Negative Regulation Of Mature B Cell Apoptotic Process B Cell Differentiation DATP Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?