GSC2 and GUCY1A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GSC2	GUCY1A2
Description		goosecoid homeobox 2	guanylate cyclase 1 soluble subunit alpha 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm Cytosol Guanylate Cyclase Complex, Soluble
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Guanylate Cyclase Activity Protein Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Heme Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis	CGMP Biosynthetic Process Signal Transduction Nitric Oxide Mediated Signal Transduction Cyclic Nucleotide Biosynthetic Process Positive Regulation Of Nitric Oxide Mediated Signal Transduction CGMP-mediated Signaling Intracellular Signal Transduction Response To Oxygen Levels
Pathways			Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction Smooth Muscle Contraction
Drugs			Nitric Oxide Isosorbide mononitrate Riociguat Methylene blue Molsidomine Isosorbide Plecanatide
Diseases
GWAS		Metabolite levels ( 22916037)	Anxiety disorder ( 25390645) Colorectal or endometrial cancer ( 26621817) Diastolic blood pressure ( 27841878) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Upper eyelid morphology ( 29921221) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Whole brain grey matter density ( 31530798)
Interacting Genes		60 interacting genes: ALPP ANXA5 ASPH BEST3 BNIP2 C19orf47 C1D CALM1 CALM2 CALM3 CALR CDKN2D CIAO2A COL8A1 CRCP CSNK2A1 DYRK1B EGLN3 EIF5A ETFDH FAM221B FKBP6 GALNT11 GCM2 GTF2H5 GTSF1L GUCA1A GUCY1A2 HMBOX1 ISX KDM6A KLHL38 KRT34 KRTAP5-9 LCE3E LTO1 MAD2L2 MAPK9 MARF1 MID2 MORF4L1 MRPL53 MRPS23 NME7 PACSIN2 PDE4C PRKAB2 PTER RNF4 SCAF1 SDCBP TIPIN TNPO2 TSR2 UBE2R2 VCX2 XRCC4 YPEL5 ZNF444 ZNF587	9 interacting genes: DLG1 DLG2 DLG3 DLG4 ERBIN GSC2 GUCY1B1 SNTA1 STUB1
Entrez ID		2928	2977
HPRD ID		03506	03146
Ensembl ID		ENSG00000063515	ENSG00000152402
Uniprot IDs		O15499	P33402
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Communication By Electrical Coupling Detection Of Calcium Ion Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of High Voltage-gated Calcium Channel Activity Titin Binding Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity DNA Metabolic Process Response To Metal Ion Protein Phosphatase Activator Activity Calyx Of Held Protein Binding Catalytic Complex Negative Regulation Of Transporter Activity Response To Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Striated Muscle Contraction DNA Damage Response Spindle Microtubule Negative Regulation Of Monoatomic Ion Transport Nucleic Acid Metabolic Process Presynaptic Endocytosis Substantia Nigra Development Sarcoplasmic Reticulum Lumen Calcium Channel Regulator Activity Detection Of Chemical Stimulus Sperm Midpiece Adenylate Cyclase Binding Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Nucleobase-containing Compound Metabolic Process	Neuromuscular Junction Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Kinase Binding Ionotropic Glutamate Receptor Binding Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Cell Polarity Protein Localization To Synapse Protein Localization To Cell Junction Postsynaptic Density Membrane Adherens Junction Glutamatergic Synapse Basolateral Plasma Membrane GMP Kinase Activity Chemical Synaptic Transmission GDP Metabolic Process Protein Localization To Membrane Neuron Projection Trans-synaptic Signaling Juxtaparanode Region Of Axon Synaptic Signaling Cellular Response To Potassium Ion Cell Adhesion Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Biological Quality Response To Potassium Ion Protein Kinase Binding Cell-cell Adhesion AMPA Glutamate Receptor Complex GMP Metabolic Process Localization Within Membrane Protein Localization To Postsynaptic Membrane Regulation Of System Process Cell Junction Protein Localization To Postsynapse Nervous System Development Cell-cell Signaling Regulation Of Sodium Ion Transmembrane Transport Signaling Hsp90 Protein Binding Cell Communication Postsynaptic Density Regulation Of Blood Circulation Phosphatase Binding Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process System Process Ribose Phosphate Metabolic Process
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